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CCT365623 hydrochloride - 98%, high purity , CAS No.2126136-98-7

COA

Grade & Purity:

≥98%

Cas Number: 2126136-98-7
Molecular Weight: 443.99
PubChem CID: 139266765

In stock

Item Number

C651445

Grouped product items
SKU	Size	Availability	Price
C651445-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$290.90
C651445-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
C651445-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,350.90

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Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor, with an IC 50 of 0.89 μM. CCT365623 hydrochloride suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF . CCT365623 hydrochloride is extremely well tolerated, and has good
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor, with an IC 50 of 0.89 μM. CCT365623 hydrochloride suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF . CCT365623 hydrochloride is extremely well tolerated, and has good pharmacokinetic properties In Vitro CCT365623 inhibits LOX at ~5 μM in the biosensor system. CCT365623 (0-40 μM) concentration-dependently decreases the protein levels of surface EGFR. CCT365623 (5 μM) decreases the protein levels of pY1068 EGFR, pAKT and MATN2, and increases the protein levels of pSMAD2. CCT365623 disrupts HTRA1 multimerization, activates TGFβ1 signalling, suppresses MATN2 expression, suppresses EGFR surface retention, and suppresses EGFR signalling. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MDA-MB-231 cells. Concentration: 0-40 μM. Incubation Time: 24 hours Result: Significantly decreased the protein levels of surface EGFR, pY1068 EGFR, pAKT and MATN2. Increased the protein levels of pSMAD2. In Vivo CCT365623 displays good stability in mouse liver microsomes and does not inhibit the cardiac potassium channel hERG . CCT365623 (70 mg/kg, oral gavage per day) significantly delays the development of the primary tumors and also suppresses metastatic lung burden in the animals. CCT365623 disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumor cell . CCT365623 exhibits a T 1/2 PO of 0.6 h and F% (oral bioavailability) of 45% . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mouse model of spontaneous breast cancer that metastasizes to the lungs (70 days old) . Dosage: 70 mg/kg. Administration: Oral gavage per day for about 3 weeks. Result: Significantly reduced MATN2 protein levels in both the primary and metastatic lung tumors and this is accompanied by the loss of EGFR from the plasma membranes of the cells in both the primary and metastatic tumors. Form:Solid IC50& Target:IC50: 0.89 μM (LOX)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Biphenyls and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Biphenyls and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Biphenyls and derivatives
Alternative Parents	Benzenesulfonyl compounds Aralkylamines 2,5-disubstituted thiophenes Sulfones Heteroaromatic compounds Organopnictogen compounds Organic oxides Monoalkylamines Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Biphenyl - Benzenesulfonyl group - Aralkylamine - 2,5-disubstituted thiophene - Heteroaromatic compound - Thiophene - Sulfonyl - Sulfone - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Hydrochloride - Primary amine - Organosulfur compound - Organonitrogen compound - Primary aliphatic amine - Amine - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	[5-(3-methylsulfonyl-5-phenylphenyl)sulfonylthiophen-2-yl]methanamine;hydrochloride
INCHI	InChI=1S/C18H17NO4S3.ClH/c1-25(20,21)16-9-14(13-5-3-2-4-6-13)10-17(11-16)26(22,23)18-8-7-15(12-19)24-18;/h2-11H,12,19H2,1H3;1H
InChIKey	MKBRQENFVVWIGU-UHFFFAOYSA-N
Smiles	CS(=O)(=O)C1=CC(=CC(=C1)C2=CC=CC=C2)S(=O)(=O)C3=CC=C(S3)CN.Cl
PubChem CID	139266765
Molecular Weight	443.99

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