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CC-115 hydrochloride - 98%, high purity , CAS No.1300118-55-1

COA

Grade & Purity:

≥98%

Cas Number: 1300118-55-1
Molecular Weight: 372.81
PubChem CID: 67153895

In stock

Item Number

C646533

Grouped product items
SKU	Size	Availability	Price
C646533-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$90.90
C646533-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
C646533-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$520.90

View related series

Cell Cycle/DNA Damage (2602) DNA Damage (697) DNA-PK (29) mTOR (145) PI3K/Akt/mTOR (765)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC 50 s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC 50 s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling. In Vitro CC-115 inhibits PC-3 cells proliferation with an IC 50 of 138 nM. In a kinase selectivity assessment against a panel of 250 protein kinases at 3 μM, only one kinase other than mTOR kinase is identified with more than 50% inhibition (cFMS 57%, IC 50 =2.0 μM). Of the PI3K related kinases (PIKKs) tested, CC-115 proves to be equipotent against DNA PK (IC 50 =15 nM) and demonstrates 40 to >1000 fold selectivity against the remaining PIKKs tested; PI3K-alpha (IC 50 =0.85 μM), ATR (50% inhibition at 30 μM) and ATM (IC 50 >30 μM). The IC 50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG (human ether-a-go-go-related gene) ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target is inhibited >50% (PDE3, IC 50 =0.63 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo CC-115 hydrochloride shows good in vivo PK profiles across multiple species with 53%, 76% and ~100% oral bioavailability in mouse, rat and dog, respectively. CC-115 is tested at lower doses of 0.25, 0.5 and 1 mg/kg bid or 1 mg/kg qd, with observed corresponding tumor volume reductions of 46%, 57%, 66% and 57% respectively. CC-115 sustains inhibition though 24 hours. At the 1 mg/kg dose CC-115 shows significant inhibition at 1 and 3 hours, CC-115 demonstrating inhibition through 10 hours. CC-115 is evaluated using both once (qd) and twice (bid) daily dosing schedules . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:DNA-PK 13 nM (IC 50 ) mTOR 21 nM (IC 50 ) mTORC1 mTORC2 PI3Kα 852 nM (IC 50 )

Names and Identifiers

Smiles	CCN1C(=O)CNC2=NC=C(N=C21)C3=C(N=C(C=C3)C4=NC=NN4)C.Cl
Isomeric SMILES	CCN1C(=O)CNC2=NC=C(N=C21)C3=C(N=C(C=C3)C4=NC=NN4)C.Cl
PubChem CID	67153895
Molecular Weight	372.81

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	H2O : 50 mg/mL (134.12 mM; Need ultrasonic) DMSO : ≥ 30 mg/mL (80.47 mM)
Molecular Weight	372.800 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	372.121 Da
Monoisotopic Mass	372.121 Da
Topological Polar Surface Area	113.000 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	491.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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