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Cathepsin D, Human Liver

COA

Grade & Purity:

≥95%(SDS-PAGE)
Extinction Coefficient: 1.0

Accession #: P07339

In stock

Item Number

np001110

Grouped product items
SKU	Size	Availability	Price
np001110-10μg	10μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$172.90
np001110-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$574.90
np001110-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,049.90

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Click to view protein information: CTSD

Amino Acid/Protein Metabolism (1836) Enzymes & Inhibitors (30) Human Proteins (109)

Basic Description

Product Name	Cathepsin D, Human Liver
Product Description	Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node-negative and node-positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers. Activity: >=300 units per mg protein. One unit is defined as the amount of enzyme that digests hemoglobin-releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A 280 of 1.0 per 60 minutes at 37°C . Substrate: acid denatured hemoglobin, pH 1.8 (0.2% in reaction mixture). Buffer: 100 mM formate, pH 3.3. Product Citations: Armstrong, Andrea, Niklas Mattsson, Hanna Appelqvist, Camilla Janefjord, Linnea Sandin, Lotta Agholme, Bob Olsson et al. "Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer’s Disease." Neuromolecular medicine (2013): 1-11 Appelqvist, Hanna, et al. "Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at Phe24, Trp48, and Phe183."Annals of Clinical & Laboratory Science 42.3 (2012): 231-242. References: Barrett, A.J. 1977. Proteinases in Mammalian Cells and Tissues. (A. Barrett, ed.) 4, 209. Barrett, A.J. 1970. Biochemistry. 117, 601. Tandon, A.K. et al. 1990. N. Engl. J. Med. 322, 297. Cataldo, A.M. et al. 1990. Brain Res. 513, 181. Chang, J.C. et al. Am. Rev. Respir. Dis. 140, 958.
Specifications & Purity	≥95%(SDS-PAGE), Extinction Coefficient: 1.0
Accession #	P07339
Predicted molecular weight	42000

Storage and Shipping

Shape	Lyophilized from 2 mM Na phosphate, pH 6.5.
Concentration	Extinction Coefficient: 1.0
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Unit definition	>=300 units per mg protein. One unit is defined as the amount of enzyme that digests hemoglobin-releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A 280 of 1.0 per 60 minutes at 37°C . Substrate: acid denatured

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