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Cathepsin C-IN-5 - 95%, high purity , CAS No.2825567-97-1

COA

Grade & Purity:

≥95%

Cas Number: 2825567-97-1
Molecular Weight: 436.92

In stock

Item Number

C650486

Grouped product items
SKU	Size	Availability	Price
C650486-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
C650486-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
C650486-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
C650486-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,350.90

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Basic Description

Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC 50 s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC 50 s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity In Vitro Cathepsin C-IN-5 (compound SF38) shows inhibition in THP-1 and U937 cells with IC 50 s of 115.4, 70.2 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Cathepsin C-IN-5 (1500 mg/kg) shows no significant weight loss or toxic reaction within 7 days after the administration in ICR mice . Cathepsin C-IN-5 (10 mg/kg for p.o.; 2 mg/kg for i.v.) shows good bioavailability with F=42.07% . Cathepsin C-IN-5 (2, 10, 50 mg/kg; p.o.) shows effective antiinflammatory activity and potential protective effect in an animal model of ALI . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 male mice (acute lung injury (ALI) mice model) Dosage: 2, 10, 50 mg/kg (one hour after administration, received LPS (20 mg/kg)) Administration: P.o. Result: Decreased the levels of proinflammatory cytokines (TNF-a, IL-6, and GM-CSF) and increased the the concentration of the anti-inflammatory cytokine (IL-10) in a dose-dependent manner. Form:Solid IC50& Target:IC 50 : 59.9 nM (Cat C),4.26 µM (Cat L),>5 µM (Cat S),>5 µM (Cat B),>5 µM (Cat K)

Names and Identifiers

Smiles	CC(NC1=CC=CC(NC2=C(C=NC(NC3=NC=C(C=C3)C4=CSC=C4)=N2)Cl)=C1)=O
Molecular Weight	436.92

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 20 mg/mL (45.77 mM; ultrasonic and warming and heat to 60°C)

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