sp_raf-Aladdin Scientific

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ZM 336372, Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase

Grade & Purity:

Moligand™

≥98%

Cas Number: 208260-29-1 Compound CID: 5730

Formula: C₂₃H₂₃N₃O₃ Molecular Weight: 389.45

IUPAC Name: 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide

SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O

InChIKey: PYEFPDQFAZNXLI-UHFFFAOYSA-N

InChI: InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)

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B-Raf inhibitor 1 dihydrochloride

Grade & Purity:

≥97%

Cas Number: 1191385-19-9 Compound CID: 44247765

Formula: C₂₆H₂₁Cl₃N₈ Molecular Weight: 551.86

IUPAC Name: 1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine;dihydrochloride

SMILES: CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6.Cl.Cl

InChIKey: HRLQRNBAJCQMMG-UHFFFAOYSA-N

InChI: InChI=1S/C26H19ClN8.2ClH/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23;;/h2-14H,1show more

Synonyms: 1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine | dihydrochloride

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GW5074, Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase

Grade & Purity:

Moligand™

≥97%

Cas Number: 220904-83-6

Formula: C₁₅H₈Br₂INO₂ Molecular Weight: 520.94

IUPAC Name: (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one

SMILES: C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2

InChIKey: LMXYVLFTZRPNRV-KMKOMSMNSA-N

InChI: InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-

Synonyms: Q27077947 | (3Z)-3-[(3,5-dibromo-4-hydroxy-phenyl)methylene]-5-iodo-indolin-2-one | GW 5074 | Lopac0_000510 | 5-iodo-...

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RAF265 (CHIR-265), Vascular endothelial growth factor receptor 2 inhibitor

Grade & Purity:

Moligand™

≥98%

Cas Number: 927880-90-8 Compound CID: 11656518

Formula: C₂₄H₁₆F₆N₆O Molecular Weight: 518.43

IUPAC Name: 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine

SMILES: CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F

InChIKey: YABJJWZLRMPFSI-UHFFFAOYSA-N

InChI: InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,show more

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PLX-4720, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of kinase insert domain receptor

Grade & Purity:

Moligand™

≥99%

Cas Number: 918505-84-7

Formula: C₁₇H₁₄ClF₂N₃O₃S Molecular Weight: 413.83

IUPAC Name: N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide

SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)Cl)F

InChIKey: YZDJQTHVDDOVHR-UHFFFAOYSA-N

InChI: InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)

Synonyms: AKOS015919071 | N-[3-(5-Chloro-7-azaindole-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide | HMS3750K11 | N-[3-(...

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Regorafenib (BAY 73-4506), Nerve growth factor receptor Trk-A

Grade & Purity:

Moligand™

≥99%

Cas Number: 755037-03-7 Compound CID: 11167602

Formula: C₂₁H₁₅ClF₄N₄O₃ Molecular Weight: 482.82

IUPAC Name: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide

SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F

InChIKey: FNHKPVJBJVTLMP-UHFFFAOYSA-N

InChI: InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29show more

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SB590885

Grade & Purity:

≥98%

Cas Number: 405554-55-4 Compound CID: 135421339

Formula: C₂₇H₂₇N₅O₂ Molecular Weight: 453.54

IUPAC Name: (NE)-N-[5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine

SMILES: CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC5=C(C=C4)C(=NO)CC5

InChIKey: MLSAQOINCGAULQ-QFMPWRQOSA-N

InChI: InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33Hshow more

Synonyms: SB-590885 | SB 590885 | 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-ind...

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Rafoxanide

Grade & Purity:

≥98%(HPLC)

Cas Number: 22662-39-1 Compound CID: 31475

Formula: C₁₉H₁₁Cl₂I₂NO₃ Molecular Weight: 626.01

IUPAC Name: N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide

SMILES: C1=CC(=CC=C1OC2=C(C=C(C=C2)NC(=O)C3=C(C(=CC(=C3)I)I)O)Cl)Cl

InChIKey: NEMNPWINWMHUMR-UHFFFAOYSA-N

InChI: InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)

Synonyms: BDBM50022832 | Q12048733 | STK377482 | NEMNPWINWMHUMR-UHFFFAOYSA-N | SMR000768692 | N-(3-chloro-4-(4-chlorophenoxy) |...

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L-779450, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase

Grade & Purity:

Moligand™

≥96%(HPLC)

Cas Number: 303727-31-3

Formula: C₂₀H₁₄ClN₃O Molecular Weight: 347.8

IUPAC Name: 2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol

SMILES: C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC(=C(C=C4)Cl)O

InChIKey: WXJLXRNWMLWVFB-UHFFFAOYSA-N

InChI: InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)

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Vemurafenib (PLX4032, RG7204), Serine/threonine-protein kinase B-raf inhibitor

Grade & Purity:

Moligand™

≥98%

Cas Number: 918504-65-1 Compound CID: 42611257

Formula: C₂₃H₁₈ClF₂N₃O₃S Molecular Weight: 489.92

IUPAC Name: N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide

SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F

InChIKey: GPXBXXGIAQBQNI-UHFFFAOYSA-N

InChI: InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1show more

Synonyms: 1-Propanesulfonamide, N-(3-((5-(4-chlorophenyl)-1H-pyrrolo(2,3-b)pyridin-3-yl)carbonyl)-2,4-difluorophenyl)- | 207SMY...

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Locostatin

Grade & Purity:

≥98%(HPLC)

Cas Number: 90719-30-5

Formula: C₁₄H₁₅NO₃ Molecular Weight: 245.27

IUPAC Name: (4S)-4-benzyl-3-[(E)-but-2-enoyl]-1,3-oxazolidin-2-one

SMILES: CC=CC(=O)N1C(COC1=O)CC2=CC=CC=C2

InChIKey: UTZAFVPPWUIPBH-QSLRECBCSA-N

InChI: InChI=1S/C14H15NO3/c1-2-6-13(16)15-12(10-18-14(15)17)9-11-7-4-3-5-8-11/h2-8,12H,9-10H2,1H3/b6-2+/t12-/m0/s1

Synonyms: (S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one|Locostatin|133812-16-5|(S,E)-4-BENZYL-3-(BUT-2-ENOYL)OXAZOLIDIN-2-ONE|90...

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AD80

Grade & Purity:

≥99%

Cas Number: 1384071-99-1

Formula: C₂₂H₁₉F₄N₇O Molecular Weight: 473.44

IUPAC Name: 1-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea

SMILES: CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)N

InChIKey: CYORWDWRQMVGHN-UHFFFAOYSA-N

InChI: InChI=1S/C22H19F4N7O/c1-11(2)33-20-17(19(27)28-10-29-20)18(32-33)12-3-6-14(7-4-12)30-21(34)31-16-9-13(22(24,25)26)5-8-15(16)23/h3-11H,1-2H3,(H2,27,28,show more

Synonyms: N-[4-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

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