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Regulators of G protein Signaling (RGS) proteins

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12 Items

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  1. (4Z)-1-(3-fluorophenyl)-4-(2-oxo-1H-indol-3-ylidene)pyrazolidine-3,5-dione, Inhibitor of regulator of G-protein signaling 4
    IUPAC Name:  (4Z)-1-(3-fluorophenyl)-4-(2-oxo-1H-indol-3-ylidene)pyrazolidine-3,5-dione
    SMILES:  Fc1cccc(c1)N1NC(=O)/C(=C\2/C(=O)Nc3c2cccc3)/C1=O
    InChIKey: CDNIIUJDSUXPEZ-YPKPFQOOSA-N
    InChI:  InChI=1S/C17H10FN3O3/c18-9-4-3-5-10(8-9)21-17(24)14(16(23)20-21)13-11-6-1-2-7-12(11)19-15(13)22/h1-8H,(H,19,22)(H,20,23)/b14-13-
  2. (5E)-1-(4-fluorophenyl)-5-[(5-methylthiophen-2-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione, Inhibitor of regulator of G-protein signaling 4
    IUPAC Name:  (5E)-1-(4-fluorophenyl)-5-[(5-methylthiophen-2-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
    SMILES:  Fc1ccc(cc1)N1C(=S)NC(=O)/C(=C\c2ccc(s2)C)/C1=O
    InChIKey: KXFOCXRVKPGLHA-MDWZMJQESA-N
    InChI:  InChI=1S/C16H11FN2O2S2/c1-9-2-7-12(23-9)8-13-14(20)18-16(22)19(15(13)21)11-5-3-10(17)4-6-11/h2-8H,1H3,(H,18,20,22)/b13-8+
  3. (5Z)-1-(2-fluorophenyl)-2-sulfanylidene-5-(thiophen-2-ylmethylidene)-1,3-diazinane-4,6-dione, Inhibitor of regulator of G-protein signaling 4
    IUPAC Name:  (5Z)-1-(2-fluorophenyl)-2-sulfanylidene-5-(thiophen-2-ylmethylidene)-1,3-diazinane-4,6-dione
    SMILES:  O=C1NC(=S)N(C(=O)/C/1=C\c1cccs1)c1ccccc1F
    InChIKey: MKKQUOFAFVQDCS-NTMALXAHSA-N
    InChI:  InChI=1S/C15H9FN2O2S2/c16-11-5-1-2-6-12(11)18-14(20)10(13(19)17-15(18)21)8-9-4-3-7-22-9/h1-8H,(H,17,19,21)/b10-8-
  4. (E)-N-[2,2-dimethyl-3-[[(E)-3-(5-methylfuran-2-yl)prop-2-enoyl]amino]propyl]-3-(5-methylfuran-2-yl)prop-2-enamide, Inhibitor of regulator of G-protein signaling 17
    IUPAC Name:  (E)-N-[2,2-dimethyl-3-[[(E)-3-(5-methylfuran-2-yl)prop-2-enoyl]amino]propyl]-3-(5-methylfuran-2-yl)prop-2-enamide
    SMILES:  O=C(/C=C/c1ccc(o1)C)NCC(CNC(=O)/C=C/c1ccc(o1)C)(C)C
    InChIKey: TVCXEKBERMLWAZ-WGDLNXRISA-N
    InChI:  InChI=1S/C21H26N2O4/c1-15-5-7-17(26-15)9-11-19(24)22-13-21(3,4)14-23-20(25)12-10-18-8-6-16(2)27-18/h5-12H,13-14H2,1-4H3,(H,22,24)(H,23,25)/b11-9+,12-1show more
    Synonyms: compound I
  5. 4-tert-butyl-N-[6-(furan-2-ylmethylsulfanyl)-1,3-dimethyl-2-oxobenzimidazol-5-yl]benzamide, Inhibitor of regulator of G-protein signaling 17
    IUPAC Name:  4-tert-butyl-N-[6-(furan-2-ylmethylsulfanyl)-1,3-dimethyl-2-oxobenzimidazol-5-yl]benzamide
    SMILES:  O=C(c1ccc(cc1)C(C)(C)C)Nc1cc2c(cc1SCc1ccco1)n(c(=O)n2C)C
    InChIKey: YTVRQZGDIKFCPL-UHFFFAOYSA-N
    InChI:  InChI=1S/C25H27N3O3S/c1-25(2,3)17-10-8-16(9-11-17)23(29)26-19-13-20-21(28(5)24(30)27(20)4)14-22(19)32-15-18-7-6-12-31-18/h6-14H,15H2,1-5H3,(H,26,29)
    Synonyms: compound V
  6. ethyl (E)-3-[3-amino-2-cyano-1-[(E)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate, Inhibitor of regulator of G-protein signaling 17
    IUPAC Name:  ethyl (E)-3-[3-amino-2-cyano-1-[(E)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate
    SMILES:  CCOC(=O)/C=C/SC(=C(C(=O)N)C#N)S/C=C/C(=O)OCC
    InChIKey: NLFBCYMMUAKCPC-KQQUZDAGSA-N
    InChI:  InChI=1S/C14H16N2O5S2/c1-3-20-11(17)5-7-22-14(10(9-15)13(16)19)23-8-6-12(18)21-4-2/h5-8H,3-4H2,1-2H3,(H2,16,19)/b7-5+,8-6+
    Synonyms: compound III
  7. irigenol, Inhibitor of regulator of G-protein signaling 17
    IUPAC Name:  5,6,7-trihydroxy-3-(3,4,5-trihydroxyphenyl)chromen-4-one
    SMILES:  Oc1cc(cc(c1O)O)c1coc2c(c1=O)c(O)c(c(c2)O)O
    InChIKey: DFURNQJNFBMYHM-UHFFFAOYSA-N
    InChI:  InChI=1S/C15H10O8/c16-7-1-5(2-8(17)13(7)20)6-4-23-10-3-9(18)14(21)15(22)11(10)12(6)19/h1-4,16-18,20-22H
    Synonyms: compound 4
  8. 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione, Inhibitor of regulator of G-protein signaling 17
    IUPAC Name:  1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione
    SMILES:  Cc1ccc(cc1)S(=O)(=O)C(C(=O)c1ccc(cc1)Cl)CC(=O)c1ccc(cc1)Cl
    InChIKey: HTSGKJQDMSTCGS-UHFFFAOYSA-N
    InChI:  InChI=1S/C23H18Cl2O4S/c1-15-2-12-20(13-3-15)30(28,29)22(23(27)17-6-10-19(25)11-7-17)14-21(26)16-4-8-18(24)9-5-16/h2-13,22H,14H2,1H3
    Synonyms: compound II
  9. 2-(5-methylfuran-2-yl)-N-(4-methylphenyl)quinoline-4-carboxamide, Inhibitor of regulator of G-protein signaling 17
    IUPAC Name:  2-(5-methylfuran-2-yl)-N-(4-methylphenyl)quinoline-4-carboxamide
    SMILES:  Cc1ccc(cc1)NC(=O)c1cc(nc2c1cccc2)c1ccc(o1)C
    InChIKey: OBTZDIRUQWFRFZ-UHFFFAOYSA-N
    InChI:  InChI=1S/C22H18N2O2/c1-14-7-10-16(11-8-14)23-22(25)18-13-20(21-12-9-15(2)26-21)24-19-6-4-3-5-17(18)19/h3-13H,1-2H3,(H,23,25)
    Synonyms: compound IV
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