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Tisotumab vedotin (anti-Tissue Factor) - Primary antibody, specific to F3, Human IgG1, Antibody of coagulation factor III; tissue factor, Antibody of coagulation factor III; tissue factor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: MC-VC-PAB-MMAE
In stock
Item Number
Ab175681
Grouped product items
SKU Size
Availability
Price Qty
Ab175681-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$189.90
Ab175681-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$919.90
Ab175681-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90
Ab175681-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,679.90

Purity≥90% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (MC-VC-PAB-MMAE)

Basic Description

Product Name Tisotumab vedotin (anti-Tissue Factor) - Primary antibody, specific to F3, Human IgG1, Antibody of coagulation factor III; tissue factor
Synonyms CD142 antibody | CD142 antigen antibody | Coagulation factor III (thromboplastin tissue factor) antibody | Coagulation factor III antibody | F3 antibody | FLJ17960 antibody | TF antibody | TF_HUMAN antibody | TFA antibody | Thromboplastin antibody | Tissu
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity F3
Conjugation MC-VC-PAB-MMAE
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of coagulation factor III; tissue factor
Product Description

Tisotumab vedotin (anti-Tissue Factor) is an antibody-drug conjugate (ADC) targeting tissue factor (TF). Tisotumab vedotin (anti-Tissue Factor) consists of a fully human monoclonal antibody to tissue factor (TF-011) conjugated to Monomethyl Auristatin E (MMAE). Tisotumab vedotin (anti-Tissue Factor) has good antitumor activity and can be used in the research of advanced or metastatic solid tumors.
Purity
≥90% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 144.66 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1418731-10-8

Associated Targets(Human)

F3 Tclin Tissue factor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Tisotumab vedotin (anti-Tissue Factor) (Ab175681) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling Tissue Factor (red) with Tisotumab vedotin (anti-Tissue Factor) (Ab175681). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Tisotumab vedotin (anti-Tissue Factor) (Ab175681) - SEC
The purity of Tisotumab vedotin (anti-Tissue Factor) (Ab175681) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0809234 Certificate of Analysis Aug 05, 2024 Ab175681
ZJ24F0809233 Certificate of Analysis Aug 05, 2024 Ab175681
ZJ24F0809232 Certificate of Analysis Aug 05, 2024 Ab175681

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