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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175681-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$189.90
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Ab175681-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$919.90
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Ab175681-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,299.90
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Ab175681-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$3,679.90
|
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Purity≥90% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (MC-VC-PAB-MMAE)
| Product Name | Tisotumab vedotin (anti-Tissue Factor) - Primary antibody, specific to F3, Human IgG1, Antibody of coagulation factor III; tissue factor |
|---|---|
| Synonyms | CD142 antibody | CD142 antigen antibody | Coagulation factor III (thromboplastin tissue factor) antibody | Coagulation factor III antibody | F3 antibody | FLJ17960 antibody | TF antibody | TF_HUMAN antibody | TFA antibody | Thromboplastin antibody | Tissu |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | F3 |
| Conjugation | MC-VC-PAB-MMAE |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of coagulation factor III; tissue factor |
| Product Description |
Tisotumab vedotin (anti-Tissue Factor) is an antibody-drug conjugate (ADC) targeting tissue factor (TF). Tisotumab vedotin (anti-Tissue Factor) consists of a fully human monoclonal antibody to tissue factor (TF-011) conjugated to Monomethyl Auristatin E (MMAE). Tisotumab vedotin (anti-Tissue Factor) has good antitumor activity and can be used in the research of advanced or metastatic solid tumors. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 144.66 kDa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1418731-10-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Tisotumab vedotin (anti-Tissue Factor) (Ab175681) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling Tissue Factor (red) with Tisotumab vedotin (anti-Tissue Factor) (Ab175681). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tisotumab vedotin (anti-Tissue Factor) (Ab175681) - SEC
The purity of Tisotumab vedotin (anti-Tissue Factor) (Ab175681) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Aug 05, 2024 | Ab175681 | |
| Certificate of Analysis | Aug 05, 2024 | Ab175681 | |
| Certificate of Analysis | Aug 05, 2024 | Ab175681 |