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Olinvacimab (anti-VEGFR2) - Primary antibody, specific to KDR, Human IgG1, INHIBITOR of Vascular endothelial growth factor receptor 2 inhibitor, INHIBITOR of Vascular endothelial growth factor receptor 2 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse,Rat
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182846
Grouped product items
SKU Size
Availability
Price Qty
Ab182846-100μg
100μg
10
$89.90
Ab182846-1mg
1mg
4
$419.90
Ab182846-5mg
5mg
1
$1,259.90
Ab182846-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,019.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Olinvacimab (anti-VEGFR2) - Primary antibody, specific to KDR, Human IgG1, INHIBITOR of Vascular endothelial growth factor receptor 2 inhibitor
Synonyms CD309 antibody | CD309 antigen antibody | EC 2.7.10.1 antibody | Fetal liver kinase 1 antibody | FLK-1 antibody | FLK1 antibody | FLK1, mouse, homolog of antibody | Kdr antibody | Kinase insert domain receptor (a type III receptor tyrosine kinase) antibod
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity KDR
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Vascular endothelial growth factor receptor 2 inhibitor
Product Description

Olinvacimab (anti-VEGFR2) is a fully human anti-VEGFR2 monoclonal antibody. Olinvacimab (anti-VEGFR2) inhibits VEGF binds to KDR with a Kd value of 0.23 nM. Olinvacimab (anti-VEGFR2) has antiangiogenic activity. Olinvacimab (anti-VEGFR2) can be used for the research of recurrent glioblastoma and breast cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg


Product Properties

Isotype Human IgG1
Light Chain Type lambda
SDS-PAGE 28.6 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 214.8 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2095504-49-5

Associated Targets(Human)

KDR Tclin Vascular endothelial growth factor receptor 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin VEGF-receptor 2 and Fibroblast growth factor receptor 2 (15 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin VEGF-receptor 2 and Fibroblast growth factor receptor 1 (50 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin TEL/KDR (9 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Olinvacimab (anti-VEGFR2) (Ab182846) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling VEGFR2 (red) with Olinvacimab (anti-VEGFR2) (Ab182846). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Olinvacimab (anti-VEGFR2) (Ab182846) - SEC
The purity of Olinvacimab (anti-VEGFR2) (Ab182846) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404831 Certificate of Analysis Apr 24, 2024 Ab182846
ZJ24F0404830 Certificate of Analysis Apr 24, 2024 Ab182846
ZJ24F0404829 Certificate of Analysis Apr 24, 2024 Ab182846

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