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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175500-100μg
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100μg |
10
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$129.90
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Ab175500-1mg
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1mg |
4
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$619.90
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Ab175500-5mg
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5mg |
1
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$1,609.90
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Ab175500-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$2,569.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Crizanlizumab (anti-P-Selectin) - Primary antibody, specific to SELP, >95%, high purity, Human IgG2, Antibody of selectin P (CD62) |
|---|---|
| Synonyms | Antigen CD62 antibody | CD62 antibody | CD62 antigen-like family member P antibody | CD62P antibody | GMP 140 antibody | GMP-140 antibody | GMP140 antibody | GMRP antibody | Granule membrane protein 140 antibody | Granulocyte membrane protein antibody | G |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | SELP |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BLOCKER |
| Mechanism of action | Antibody of selectin P (CD62) |
| Product Description |
Crizanlizumab (anti-P-Selectin) is an anti-P-selectin monoclonal antibody. Crizanlizumab (anti-P-Selectin) binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab (anti-P-Selectin) prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease. |
| Isotype | Human IgG2 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.9 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1690318-25-2 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Crizanlizumab (anti-P-Selectin) (Ab175500) - ELISA
Immobilized Human P-Selectin-Fc is at 2.0 μg/mL can bind Crizanlizumab (anti-P-Selectin) (Ab175500) with the EC₅₀ of 10.58 ng/mL.
Crizanlizumab (anti-P-Selectin) (Ab175500) - SEC
The purity of Crizanlizumab (anti-P-Selectin) (Ab175500) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 29, 2024 | Ab175500 | |
| Certificate of Analysis | Mar 29, 2024 | Ab175500 | |
| Certificate of Analysis | Mar 29, 2024 | Ab175500 |
Starting at $19.90
Starting at $119.90