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Crizanlizumab (anti-P-Selectin) - Primary antibody, specific to SELP, >95%, high purity, Human IgG2, Antibody of selectin P (CD62), Antibody of selectin P (CD62)

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG2
  • Conjugation: Unconjugated
In stock
Item Number
Ab175500
Grouped product items
SKU Size
Availability
Price Qty
Ab175500-100μg
100μg
10
$129.90
Ab175500-1mg
1mg
4
$619.90
Ab175500-5mg
5mg
1
$1,609.90
Ab175500-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,569.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Crizanlizumab (anti-P-Selectin) - Primary antibody, specific to SELP, >95%, high purity, Human IgG2, Antibody of selectin P (CD62)
Synonyms Antigen CD62 antibody | CD62 antibody | CD62 antigen-like family member P antibody | CD62P antibody | GMP 140 antibody | GMP-140 antibody | GMP140 antibody | GMRP antibody | Granule membrane protein 140 antibody | Granulocyte membrane protein antibody | G
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity SELP
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type BLOCKER
Mechanism of action Antibody of selectin P (CD62)
Product Description

Crizanlizumab (anti-P-Selectin) is an anti-P-selectin monoclonal antibody. Crizanlizumab (anti-P-Selectin) binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab (anti-P-Selectin) prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease.

Product Properties

Isotype Human IgG2
Light Chain Type kappa
SDS-PAGE 26.9 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1690318-25-2

Associated Targets(Human)

SELP Tclin P-selectin (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Crizanlizumab (anti-P-Selectin) (Ab175500) - ELISA
Immobilized Human P-Selectin-Fc is at 2.0 μg/mL can bind Crizanlizumab (anti-P-Selectin) (Ab175500) with the EC₅₀ of 10.58 ng/mL.

Crizanlizumab (anti-P-Selectin) (Ab175500) - SEC
The purity of Crizanlizumab (anti-P-Selectin) (Ab175500) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0303906 Certificate of Analysis Mar 29, 2024 Ab175500
ZJ24F0303905 Certificate of Analysis Mar 29, 2024 Ab175500
ZJ24F0303904 Certificate of Analysis Mar 29, 2024 Ab175500

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