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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175467-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$69.90
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Ab175467-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$309.90
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Ab175467-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$809.90
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Ab175467-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,289.90
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Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Conjugated (MC-VC-PAB-MMAF)
| Product Name | Belantamab mafodotin (anti-BCMA) - Primary antibody, specific to TNFRSF17, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of B cell maturation antigen |
|---|---|
| Synonyms | B cell maturation antigen antibody | B cell maturation factor antibody | B cell maturation protein antibody | B-cell maturation protein antibody | BCM antibody | BCMA antibody | CD269 antibody | CD269 antigen antibody | TNFRSF17 antibody | TNR17_HUMAN ant |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. |
| Host species | Human |
| Specificity | TNFRSF17 |
| Conjugation | MC-VC-PAB-MMAF |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | Antibody of B cell maturation antigen |
| Product Description |
Belantamab mafodotin (anti-BCMA) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. Belantamab mafodotin has anti-myeloma activity.
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| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145 kDa |
| Purification Method | Protein A purified |
| Purity | >90% (SDS-PAGE&SEC) |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2050232-20-5 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Belantamab mafodotin (anti-BCMA) (Ab175467) - Flow Cytometry
Flow Cytometry analysis of U266 cells labelling BCMA (red) with Belantamab mafodotin (anti-BCMA) (Ab175467) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Belantamab mafodotin (anti-BCMA) (Ab175467) - ELISA
Immobilized Recombinant Human BCMA/TNFRSF17(Fc) protein (rp169554) at 1.0 μg/mL can bind Belantamab mafodotin (anti-BCMA) (Ab175467) with the EC50 of 40.09 ng/mL.
Belantamab mafodotin (anti-BCMA) (Ab175467) - ELISA
Immobilized Recombinant huBCMA- ECD-His protein at 2.0 μg/mL can bind Belantamab mafodotin (anti-BCMA) (Ab175467) with the EC50 of 26.34 ng/mL.
Belantamab mafodotin (anti-BCMA) (Ab175467) - SEC
The purity of Belantamab mafodotin (anti-BCMA) (Ab175467) is more than 95% verified by HPLC.