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Carazolol hydrochloride , CAS No.51997-43-4, Antagonist of β 2-adrenoceptor;Agonist of β 3-adrenoceptor

In stock
Item Number
C276012
Grouped product items
SKU Size
Availability
Price Qty
C276012-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$204.90
C276012-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,610.90

High-affinity beta-adrenoceptor ligand.

Basic Description

Synonyms (RS)-Carazololhydrochlorid | Carazolol Hydrochloride Salt | Q27259666 | starbld0016805 | 1-((9H-Carbazol-4-yl)oxy)-3-(isopropylamino)propan-2-ol hydrochloride | NSC305336 | NSC-305336 | 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((1-methylethyl)amino)-, hydroc
Specifications & Purity Moligand™
Biochemical and Physiological Mechanisms Promising high-affinity beta-adrenoceptor ligand for the noninvasive determination of beta receptor status using PET.
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST, ANTAGONIST
Mechanism of action Antagonist of β 2-adrenoceptor;Agonist of β 3-adrenoceptor
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Indoles and derivatives
Subclass Carbazoles
Intermediate Tree Nodes Not available
Direct Parent Carbazoles
Alternative Parents Indoles  Phenol ethers  Alkyl aryl ethers  Pyrroles  Heteroaromatic compounds  Secondary alcohols  1,2-aminoalcohols  Dialkylamines  Azacyclic compounds  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Carbazole - Indole - Phenol ether - Alkyl aryl ether - Benzenoid - Heteroaromatic compound - Pyrrole - Secondary alcohol - 1,2-aminoalcohol - Azacycle - Secondary amine - Secondary aliphatic amine - Ether - Hydrocarbon derivative - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Amine - Hydrochloride - Alcohol - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as carbazoles. These are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.
External Descriptors Not available

Associated Targets(Human)

ADRB2 Tclin Beta-2 adrenergic receptor (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ADRB3 Tclin Beta-3 adrenergic receptor (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol;hydrochloride
INCHI InChI=1S/C18H22N2O2.ClH/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16;/h3-9,12-13,19-21H,10-11H2,1-2H3;1H
InChIKey DXYNUICMBSWZMR-UHFFFAOYSA-N
Smiles CC(C)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O.Cl
Isomeric SMILES CC(C)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O.Cl
Molecular Weight 334.8
Reaxy-Rn 15611605
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=15611605&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility DMSO
Molecular Weight 334.800 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 6
Exact Mass 334.145 Da
Monoisotopic Mass 334.145 Da
Topological Polar Surface Area 57.300 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 350.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

Reviews

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