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camonsertib , CAS No.C608306, Inhibitor of ATR serine/threonine kinase

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 2417489-10-0
Molecular Weight: 410.47
PubChem CID: 156487652

In stock

Item Number

C608306

Grouped product items
SKU	Size	Availability	Price
C608306-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$163.90
C608306-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$416.90
C608306-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$605.90
C608306-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$943.90

View related series

ATM/ATR (31) ATR serine/threonine kinase Inhibitor (10) Cell Cycle/DNA Damage (2602) DNA Damage (697) mTOR (145) PI3K/Akt/mTOR (765)

Basic Description

Synonyms	Camonsertib \| NSC841442 \| NSC-841442 \| ATR inhibitor 4;Camonsertib \| 8-Oxabicyclo[3.2.1]octan-3-ol, 3-[6-[(3R)-3-methyl-4-morpholinyl]-1-(1H-pyrazol-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-, (3-endo)- \| Rp 3500 \| S1Z7Y5G56T \| camonsertib [INN]
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ATR serine/threonine kinase
Product Description	Camonsertib (RP-3500) is a selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity.

Associated Targets(Human)

ATR Tchem Serine/threonine-protein kinase ATR (0 Activities)

Discover Target: ATR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Smiles	C[C@@H]1COCCN1C2=NC3=C(C=NN3C4=CC=NN4)C(=C2)C5(C[C@H]6CC[C@@H](C5)O6)O
Isomeric SMILES	C[C@@H]1COCCN1C2=NC3=C(C=NN3C4=CC=NN4)C(=C2)C5(C[C@H]6CC[C@@H](C5)O6)O
Molecular Weight	410.47

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Sensitivity	light & Moisture sensitive
Molecular Weight	410.500 g/mol
XLogP3	1.600
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	410.207 Da
Monoisotopic Mass	410.207 Da
Topological Polar Surface Area	101.000 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	628.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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