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Calpeptin - 95%, high purity , CAS No.117591-20-5, Inhibitor of calpain 1;Inhibitor of cathepsin K

COA COA
In stock
Item Number
C274691
Grouped product items
SKU Size
Availability
 Price Qty
C274691-5mg
5mg
3
$64.90
C274691-10mg
10mg
2
$93.90
C274691-25mg
25mg
1
$195.90
C274691-50mg
50mg
1
$276.90
C274691-100mg
100mg
1
$444.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent, cell-permeable calpain inhibitor

View related series
Amino Acid/Protein Metabolism (1836) Apoptosis (4276) calpain 1 Inhibitor (5) Cathepsin (64) cathepsin K Inhibitor (12) CoV 3C-like (main) protease Inhibitor (66) Metabolic Enzyme/Protease (4860) Proteasome (85)

Basic Description

Synonyms Isopentanal | KBio3_000476 | Benzylcarbonyl-leu-nleu-H | EX-A2217 | HMS3675M09 | IDI1_033988 | N-benzyloxycarbonyl-L-leucyl-L-norleucinal | 18X9FR245W | 3-Bromo-propionic acid | CCG-207843 | benzyl N-[(1S)-1-[[(1S)-1-formylpentyl]carbamoyl]-3-methyl-butyl
Specifications & Purity Moligand™, ≥95%
Biochemical and Physiological Mechanisms Potent, cell-permeable calpain inhibitor, a Ca 2+ -dependent protease. K i values are 34 and 52 nM for μ- and m-calpains, respectively. Demonstrates neuroprotective effects suggesting ability to cross the blood-brain barrier.
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of calpain 1;Inhibitor of cathepsin K
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Benzene and substituted derivatives
Alternative Parents Propargyl-type 1,3-dipolar organic compounds  Carboximidic acids  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Aldehydes  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Monocyclic benzene moiety - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidic acid derivative - Carboximidic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aldehyde - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
External Descriptors amino acid amide

Associated Targets(Human)

CTSL Tclin Cathepsin L1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CTSK Tchem Cathepsin K (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CAPN1 Tchem Calpain-1 catalytic subunit (6 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTSB Tchem Cathepsin B (3822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTSK Tchem Cathepsin K (3011 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SMAD2 Tbio Mothers against decapentaplegic homolog 2 (9 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HK-2 (249 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

CTSL Cathepsin L (58 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAPN1 Calpain 1 (219 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human rhinovirus sp. (1587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COS-7 (515 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-12 (7051 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
H4 (48 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504754700
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504754700
IUPAC Name benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxohexan-2-yl]amino]pentan-2-yl]carbamate
INCHI InChI=1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1
InChIKey PGGUOGKHUUUWAF-ROUUACIJSA-N
Smiles CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Molecular Weight 362.47
Reaxy-Rn 11932732
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11932732&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
J2225229 Certificate of Analysis Aug 22, 2023 C274691
J2225241 Certificate of Analysis Aug 22, 2023 C274691
J2225244 Certificate of Analysis Aug 22, 2023 C274691
J2225243 Certificate of Analysis Aug 22, 2023 C274691
J2225237 Certificate of Analysis Aug 22, 2023 C274691

Chemical and Physical Properties

Solubility Soluble in ethanol to 100 mM and in DMSO to 100mM
Molecular Weight 362.500 g/mol
XLogP3 3.900
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 12
Exact Mass 362.221 Da
Monoisotopic Mass 362.221 Da
Topological Polar Surface Area 84.500 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 434.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. Calpeptin, Inhibitor of calpain 1;Inhibitor of cathepsin K
    Calpeptin, Inhibitor of calpain 1;Inhibitor of cathepsin K

    Starting at $160.90

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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