This is a demo store. No orders will be fulfilled.

 
Call +1 (833) 552-7181 or Contact us
Toggle Nav
My Cart
Search
Advanced Search
Menu
Account
Settings
྾
main product photo

Calcifediol - ≥97%, high purity , CAS No.19356-17-3

5 Citations COA COA
In stock
Item Number
C125817
Grouped product items
SKU Size
Availability
 Price Qty
C125817-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$29.90
C125817-5mg
5mg
2
$117.90
C125817-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$375.90
C125817-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$969.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

The major circulating metabolite of vitamin D 3 (Cholecalciferol). Calcifediol also has mineralizing properties.

View related series
Endogenous Metabolite (959) Metabolic Enzyme/Protease (4860) Metabolite (5307) VD/VDR (83) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Synonyms Calcidiol | 25-Hydroxyvitamin D3 monohydrate, >=99.0% (HPLC) | Cholecalciferol, 25-hydroxy- | 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL | Calcifediol | HMS1791G13 | BDBM50521013 | 1H-I
Specifications & Purity Moligand™, ≥97%
Biochemical and Physiological Mechanisms 25-Hydroxyvitamin D3 is the major circulating form of vitamin D.Principal cholecalciferol metabolite. Downregulates TLR4 and JAK1/STAT3 signaling. Hydroxylates to calcitriol in vivo . Anti-inflammatory effects. Orally active.
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM).
A major circulating metabolite of vitamin D3

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Steroids and steroid derivatives
Subclass Vitamin D and derivatives
Intermediate Tree Nodes Not available
Direct Parent Vitamin D and derivatives
Alternative Parents Triterpenoids  Tertiary alcohols  Secondary alcohols  Cyclic alcohols and derivatives  Hydrocarbon derivatives  
Molecular Framework Aliphatic homopolycyclic compounds
Substituents Triterpenoid - Tertiary alcohol - Cyclic alcohol - Secondary alcohol - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Alcohol - Aliphatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as vitamin d and derivatives. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane.
External Descriptors Vitamin D3 and derivatives

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HaCaT (4069 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP27B1 Tchem 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (12 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Gc Vitamin D-binding protein (39 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
VPAC1 Vasoactive intestinal peptide receptor (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gallus gallus (1187 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Srebf1 Sterol regulatory element-binding protein 1 (3 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
INCHI InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
InChIKey JWUBBDSIWDLEOM-DTOXIADCSA-N
Smiles CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Isomeric SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C
WGK Germany 1
Alternate CAS 63283-36-3
Molecular Weight 400.64
Reaxy-Rn 34003584
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34003584&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot Number Certificate Type Date Item
K2429125 Certificate of Analysis Dec 03, 2024 C125817
J2421289 Certificate of Analysis Oct 25, 2024 C125817
B2512083 Certificate of Analysis Oct 25, 2024 C125817
J2421290 Certificate of Analysis Oct 25, 2024 C125817
K2429124 Certificate of Analysis Oct 24, 2024 C125817
K2429123 Certificate of Analysis Oct 24, 2024 C125817
J2421291 Certificate of Analysis Oct 24, 2024 C125817
K2320218 Certificate of Analysis Mar 26, 2024 C125817
K2320219 Certificate of Analysis Mar 26, 2024 C125817
K2320220 Certificate of Analysis Mar 26, 2024 C125817
F2413053 Certificate of Analysis Mar 26, 2024 C125817
I2315030 Certificate of Analysis Sep 20, 2023 C125817
F23171132 Certificate of Analysis Jun 30, 2023 C125817
E2324273 Certificate of Analysis Jun 07, 2023 C125817
C2310598 Certificate of Analysis Apr 11, 2023 C125817
D2122151 Certificate of Analysis Feb 09, 2023 C125817
K2208082 Certificate of Analysis Nov 22, 2022 C125817
L2011013 Certificate of Analysis Oct 15, 2022 C125817
H2210029 Certificate of Analysis Aug 18, 2022 C125817

Show more⌵

Chemical and Physical Properties

Solubility Soluble in alcohol, acetone chloroform, ether, fixed oils, DMSO (~10 mg/ml), DMF (~10 mg/ml), 1:2 ethanol:PBS(pH7.2) (~0.3 mg/ml), chloroform, and methanol. Insoluble in water.
Molecular Weight 400.600 g/mol
XLogP3 6.200
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 6
Exact Mass 400.334 Da
Monoisotopic Mass 400.334 Da
Topological Polar Surface Area 40.500 Ų
Heavy Atom Count 29
Formal Charge 0
Complexity 655.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 5
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 2
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 2
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. He Qiting, Qin Ruixi, Glowacki Julie, Zhou Shuanhu, Shi Jie, Wang Shaoyi, Gao Yuan, Cheng Lei.  (2021)  Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy.  Stem Cell Research & Therapy,  12  (1): (1-13). 
2. Chen Huaiyi, Liao Ziwei, Sun Gongwei, Wu Tianhao, Yang Jinlei, Pan Siyuan, Zhang Sichun, Tang Fei.  (2025)  Affinity Capture Coupled with Nano-Electrospray Ionization-Mass Spectrometry for Rapid Detection of 25-hydroxyvitamin D3 in Serum.  Journal of Analysis and Testing,    (1-5). 
3. Cai Tongji, Chen Meilun, Yang Jie, Tang Chunhua, Lu Xiaoling, Wei Zheng, Jiang Hanbing, Hou Yucui, Zhao Jia, Yu Peng.  (2024)  An AuNPs-based electrochemical aptasensor for the detection of 25-hydroxy vitamin D3.  ANALYTICAL SCIENCES,    (1-9). 
4. Lixin Kang, Haoran Li, Kexin Lin, Shen Hu, Song Liu, Yuben Qiao, Ying Wang, Aitao Li.  (2025)  Regioselectivity Switching in CYP107Pdh-Catalyzed VD3 Hydroxylation: A Structure-Guided Approach To Improve Calcidiol Production.  ACS Catalysis,  15  (5): (4160-4171). 
5. Zi-qing Wang, Li-ping Hao, Zi-xuan Meng, Hao-ran Zhang, Wei-jun Kang, Lian-feng Ai.  (2025)  Simultaneous determination of 25(OH)D2, 25(OH)D3 and 1α,25(OH)2D3 in human serum by derivatization-liquid chromatography-tandem mass spectrometry.  ANALYTICAL BIOCHEMISTRY,  701  (115821). 

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.