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C25-140 - 98%, high purity , CAS No.1358099-18-9

COA

Grade & Purity:

≥98%

Cas Number: 1358099-18-9
Molecular Weight: 457.57
PubChem CID: 53093165

In stock

Item Number

C413582

Grouped product items
SKU	Size	Availability	Price
C413582-1mg	1mg	2	$64.90
C413582-5mg	5mg	1	$139.90
C413582-10mg	10mg	1	$216.90
C413582-25mg	25mg	1	$431.90

NF-κB Inhibitors

View related series

Amino Acid/Protein Metabolism (1836) Apoptosis (4276) E1/E2/E3 Enzyme (112) Extrinsic Pathway (436) Metabolic Enzyme/Protease (4860) NF-κB inhibitor (1) TNF Receptor (121)

Basic Description

Synonyms	1-Propanone,3-[3,5-dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inf
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information C25-140 C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction . C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells. Targets TRAF6-Ubc13 ; NF-κB

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Piperidines
    - Subclass Benzylpiperidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Piperidines
Subclass	Benzylpiperidines
Intermediate Tree Nodes	Not available
Direct Parent	4-benzylpiperidines
Alternative Parents	Triazolopyridazines N-acylpiperidines Pyridazines and derivatives Benzene and substituted derivatives Triazoles Tertiary carboxylic acid amides Pyrazoles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	4-benzylpiperidine - N-acyl-piperidine - Triazolopyridazine - Monocyclic benzene moiety - Pyridazine - Benzenoid - Azole - Pyrazole - Heteroaromatic compound - 1,2,4-triazole - Tertiary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Azacycle - Organooxygen compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 4-benzylpiperidines. These are organic compounds containing a benzyl group attached to the 4-position of a piperidine.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	1-(4-benzylpiperidin-1-yl)-3-[3,5-dimethyl-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)pyrazol-4-yl]propan-1-one
INCHI	InChI=1S/C26H31N7O/c1-18-23(19(2)32(29-18)25-11-10-24-28-27-20(3)33(24)30-25)9-12-26(34)31-15-13-22(14-16-31)17-21-7-5-4-6-8-21/h4-8,10-11,22H,9,12-17H2,1-3H3
InChIKey	HFKVRXVHZGBRKF-UHFFFAOYSA-N
Smiles	CC1=C(C(=NN1C2=NN3C(=NN=C3C=C2)C)C)CCC(=O)N4CCC(CC4)CC5=CC=CC=C5
Isomeric SMILES	CC1=C(C(=NN1C2=NN3C(=NN=C3C=C2)C)C)CCC(=O)N4CCC(CC4)CC5=CC=CC=C5
Molecular Weight	457.57
Reaxy-Rn	32604548
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32604548&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
C2414361	Certificate of Analysis	Jan 27, 2024	C413582
C2414354	Certificate of Analysis	Jan 27, 2024	C413582
C2414355	Certificate of Analysis	Jan 27, 2024	C413582
C2414362	Certificate of Analysis	Jan 27, 2024	C413582
C2414363	Certificate of Analysis	Jan 27, 2024	C413582
C2414390	Certificate of Analysis	Jan 27, 2024	C413582
C2414391	Certificate of Analysis	Jan 27, 2024	C413582
C2414392	Certificate of Analysis	Jan 27, 2024	C413582

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 92 mg/mL (201.06 mM); Ethanol: 92 mg/mL (201.06 mM); Water: Insoluble;
Molecular Weight	457.600 g/mol
XLogP3	3.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	457.259 Da
Monoisotopic Mass	457.259 Da
Topological Polar Surface Area	81.200 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	678.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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