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C 646 - 98%, high purity , CAS No.328968-36-1, Inhibitor of E1A binding protein p300

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 328968-36-1
Molecular Weight: 445.42
PubChem CID: 1285941
PubChem SID: 504760460

In stock

Item Number

C274682

Grouped product items
SKU	Size	Availability	Price
C274682-1mg	1mg	3	$9.90
C274682-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$13.90
C274682-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$27.90
C274682-100mg	100mg	3	$91.90
C274682-250mg	250mg	2	$154.90
C274682-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90

Cell-permeable, competitive, selective, potent p300/CBP HAT inhibitor

View related series

Apoptosis (4276) Autophagy (1917) E1A binding protein p300 Inhibitor (10) Epigenetic Reader Domain (314) Epigenetics (1496) Histone Acetyltransferase (79) Histone Modification (1379)

Basic Description

Synonyms	4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid \| CHEBI:132974 \| Q27075626 \| BRD-K73383190-001-03-1 \| GTPL7004 \| 4-(4-{[5-(4,5-dimethyl-2-nitrophenyl)-2-furyl]methylene}-3-methyl-5-oxo-4,5
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-κB, p53 and MyoD that are associated wit
Storage Temp	Store at -20°C,Argon charged,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of E1A binding protein p300
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzoic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzoic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Acylaminobenzoic acid and derivatives
Alternative Parents	Benzoic acids Nitrobenzenes Nitrotoluenes o-Xylenes Benzoyl derivatives Nitroaromatic compounds Pyrazolones Furans Heteroaromatic compounds Monocarboxylic acids and derivatives Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Carboxylic acids Oxacyclic compounds Organic oxoazanium compounds Organic zwitterions Organonitrogen compounds Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Organic oxides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Acylaminobenzoic acid or derivatives - Benzoic acid - Nitrobenzene - Nitrotoluene - Nitroaromatic compound - Benzoyl - O-xylene - Xylene - Pyrazolinone - Furan - Heteroaromatic compound - Pyrazoline - C-nitro compound - Organic nitro compound - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxoazanium - Oxacycle - Azacycle - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Carbonyl group - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Organic zwitterion - Organopnictogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as acylaminobenzoic acid and derivatives. These are derivatives of amino benzoic acid derivatives where the amine group is N-acylated.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

EP300 Tchem Histone acetyltransferase p300 (7 Activities)

Discover Target: EP300

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	504760460
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504760460
IUPAC Name	4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
INCHI	InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
InChIKey	HEKJYZZSCQBJGB-UNOMPAQXSA-N
Smiles	CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C
Isomeric SMILES	CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C
Molecular Weight	445.42
Reaxy-Rn	20607912
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20607912&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
L2413416	Certificate of Analysis	Dec 02, 2024	C274682
L2413417	Certificate of Analysis	Dec 02, 2024	C274682
L2413418	Certificate of Analysis	Dec 02, 2024	C274682
L2413419	Certificate of Analysis	Dec 02, 2024	C274682
L2413512	Certificate of Analysis	Dec 02, 2024	C274682
K2428177	Certificate of Analysis	Apr 07, 2024	C274682
L2123474	Certificate of Analysis	Oct 20, 2022	C274682
L2123475	Certificate of Analysis	Oct 20, 2022	C274682
L2123476	Certificate of Analysis	Oct 20, 2022	C274682
L2123473	Certificate of Analysis	Oct 20, 2022	C274682
L2123071	Certificate of Analysis	Oct 20, 2022	C274682
L2123072	Certificate of Analysis	Oct 20, 2022	C274682

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Chemical and Physical Properties

Solubility	Soluble in DMSO to 25 mM
Molecular Weight	445.400 g/mol
XLogP3	4.200
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	445.127 Da
Monoisotopic Mass	445.127 Da
Topological Polar Surface Area	129.000 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	857.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

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