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BSJ-04-122 - 99%, high purity , CAS No.2513289-74-0

COA

Grade & Purity:

≥99%

Cas Number: 2513289-74-0
Molecular Weight: 313.74

In stock

Item Number

B649627

Grouped product items
SKU	Size	Availability	Price
B649627-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$90.90
B649627-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$145.90
B649627-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$290.90
B649627-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$470.90
B649627-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90

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MAPK/ERK Pathway (546) p38 MAPK (136)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC 50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC 50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer In Vitro BSJ-04-122 has inhibitory activity for MKK4 and MKK7 with IC 50 values of 4 nM and 181 nM, respectively. BSJ-04-122 (1, 5, 10 μM; 6 h) induces robust reduction of JNK phosphorylation. BSJ-04-122 (0, 1.25, 2.5, 5, 10, 20 μM; 72 h) shows enhanced antiproliferative effects when combination with JNK-IN-8. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 1, 5, 10 μM Incubation Time: 6 h Result: Significantly decreased levels of T183/Y185 pJNK at 5 μM. Cell Proliferation AssayCell Line: MDA-MB-231 cells Concentration: 1-100 μM; 0, 1.25, 2.5, 5, 10, 20 μM Incubation Time: 72 h Result: Exhibited antiproliferative effects when combination with JNK-IN-8 in MDA-MB-231 cells. Form:Solid IC50& Target:IC50: 4 nM (MKK4),181 nM (MKK7)

Names and Identifiers

Smiles	C=CC(NC1=CC=CC=C1NC2=C3C(NC=C3Cl)=NC=N2)=O
Molecular Weight	313.74

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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