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Broussonin E - 98%, high purity , CAS No.90902-21-9

COA

Grade & Purity:

≥98%

Cas Number: 90902-21-9
Molecular Weight: 288.34
PubChem CID: 14213544

In stock

Item Number

B648106

Grouped product items
SKU	Size	Availability	Price
B648106-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
B648106-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$290.90
B648106-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$580.90

Phenols Polyphenols

View related series

Amino Acid/Protein Metabolism (1836) Apoptosis (4276) Arginase (10) COX (258) Epigenetics (1496) ERK (132) Extrinsic Pathway (436) Histone Modification (1379) Immunology/Inflammation (1929) Interleukin Related (129) JAK (149) JAK/STAT Signaling (507) MAPK/ERK Pathway (546) Metabolic Enzyme/Protease (4860) Non-receptor Tyrosine Kinase (643) p38 MAPK (136) Phenols Polyphenols (41) Protein Tyrosine Kinase/RTK (1314) STAT (139) Stem Cell/Wnt (1019) TNF Receptor (121)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis In Vitro Broussonin E (20 μM, 3 h) inhibits the LPS ( Lipopolysaccharides , HY-D1056)-stimulated phosphorylation of ERK and p38 MAPK. Broussonin E can activate janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3. Broussonin E (0-20 μM, 3 h) can suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-α, IL-1β, IL-6, COX-2 and iNOS. Broussonin E enhances the expressions of anti-inflammatory mediators such as IL-10, CD206 and arginase-1 (Arg-1) in LPS-stimulated RAW264.7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW264.7 cells Concentration: 2.5, 5, 10 and 20 Incubation Time: 3 h Result: Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells. Form:Solid IC50& Target:ERK p38 MAPK JAK2 STAT3 IL-1β IL-6 COX-2 IL-10

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Linear 1,3-diarylpropanoids
    - Subclass Cinnamylphenols

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Linear 1,3-diarylpropanoids
Subclass	Cinnamylphenols
Intermediate Tree Nodes	Not available
Direct Parent	Cinnamylphenols
Alternative Parents	Methoxyphenols Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Cinnamylphenol - Methoxyphenol - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Phenol - Benzenoid - Monocyclic benzene moiety - Ether - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as cinnamylphenols. These are organic compounds containing the 1,3-diphenylpropene moiety with one benzene ring bearing one or more hydroxyl groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol
INCHI	InChI=1S/C17H20O4/c1-20-14-8-7-13(15(18)11-14)5-3-4-12-6-9-17(21-2)16(19)10-12/h6-11,18-19H,3-5H2,1-2H3
InChIKey	GDCSYNUJDYRGRF-UHFFFAOYSA-N
Smiles	COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)OC)O)O
Isomeric SMILES	COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)OC)O)O
PubChem CID	14213544
Molecular Weight	288.34

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (346.81 mM; Need ultrasonic)
Molecular Weight	288.340 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	288.136 Da
Monoisotopic Mass	288.136 Da
Topological Polar Surface Area	58.900 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	297.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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