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Brivanib (BMS-540215) - 10mM in DMSO, high purity , CAS No.649735-46-6(DMSO), Vascular endothelial growth factor receptor inhibitor

COA COA
In stock
Item Number
B407849
Grouped product items
SKU Size
Availability
 Price Qty
B407849-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$352.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

FGFR1 Selective Inhibitors

View related series
Compound libraries (12325)

Basic Description

Synonyms (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol
Specifications & Purity Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Vascular endothelial growth factor receptor inhibitor
Product Description

Information

Brivanib is an ATP-competitive inhibitor againstVEGFR2withIC50of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
In vitro


In vivo


Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥95%

Product Properties

ALogP 3.481
hba_count 4
HBD Count 2
Rotatable Bond 5

Associated Targets(Human)

STK35 Tchem Serine/threonine-protein kinase 35 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
FGFR1 Tclin Fibroblast growth factor receptor 1 (4 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDGFRA Tclin Platelet-derived growth factor receptor alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
FLT1 Tclin Vascular endothelial growth factor receptor 1 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KDR Tclin Vascular endothelial growth factor receptor 2 (7 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KIT Tclin Mast/stem cell growth factor receptor Kit (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

Smiles CC(O)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C
Molecular Weight 370.38
Reaxy-Rn 23221919
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23221919&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 49 mg/mL (198.14 mM); Ethanol: 49 mg/mL (198.14 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility 74
DMSO(mM) Max Solubility 199.79
Water(mg / mL) Max Solubility <1

Solution Calculators

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