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BrBzGCp2 - 98%, high purity , CAS No.166038-00-2

COA

Grade & Purity:

≥98%

Cas Number: 166038-00-2
Molecular Weight: 612.58
PubChem CID: 127939

In stock

Item Number

B651195

Grouped product items
SKU	Size	Availability	Price
B651195-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$80.90
B651195-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$140.90
B651195-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
B651195-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$500.90
B651195-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90

View related series

Glucose Metabolism (1943) Glyoxalase (GLO) (7) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	AKOS040746203 \| S-4-Bromobenzylglutathione cyclopentyl diester \| Cyclopentyl N5-((R)-3-((4-bromobenzyl)thio)-1-((2-(cyclopentyloxy)-2-oxoethyl)amino)-1-oxopropan-2-yl)-L-glutaminate \| HY-136684 \| MS-30713 \| cyclopentyl (2S)-2-amino-5-[[(2R)-3-[(4-bromophe
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC 50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC 50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity In Vivo GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior. BrBzGCp2 pre-treatment decreases seizure duration. BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels. BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABA A receptor activation. BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD-1 mice. Dosage: 50 mg/kg. Administration: IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured) Result: Allowed MG levels to accumulate for 2 hours Form:Solid IC50& Target:GC50: 4.23 μM (GLO1)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Peptides
        Level6 Oligopeptides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Peptides
Direct Parent	Oligopeptides
Alternative Parents	Glutamine and derivatives Alpha amino acid esters N-acyl-alpha amino acids and derivatives Alpha amino acid amides Cysteine and derivatives Bromobenzenes Fatty acid esters Aryl bromides N-acyl amines Dicarboxylic acids and derivatives Secondary carboxylic acid amides Carboxylic acid esters Dialkylthioethers Sulfenyl compounds Organic oxides Carbonyl compounds Organobromides Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Alpha-oligopeptide - Glutamine or derivatives - Alpha-amino acid ester - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Cysteine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Bromobenzene - Fatty acid ester - Halobenzene - Fatty acyl - Benzenoid - Aryl bromide - Aryl halide - Monocyclic benzene moiety - N-acyl-amine - Fatty amide - Dicarboxylic acid or derivatives - Secondary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Carboxylic acid ester - Sulfenyl compound - Thioether - Dialkylthioether - Primary amine - Organic oxygen compound - Organopnictogen compound - Primary aliphatic amine - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Organohalogen compound - Organobromide - Organonitrogen compound - Amine - Organic oxide - Organooxygen compound - Organosulfur compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Glo1 Glyoxalase I (4 Activities)

Discover Target: Glo1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	cyclopentyl (2S)-2-amino-5-[[(2R)-3-[(4-bromophenyl)methylsulfanyl]-1-[(2-cyclopentyloxy-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate
INCHI	InChI=1S/C27H38BrN3O6S/c28-19-11-9-18(10-12-19)16-38-17-23(26(34)30-15-25(33)36-20-5-1-2-6-20)31-24(32)14-13-22(29)27(35)37-21-7-3-4-8-21/h9-12,20-23H,1-8,13-17,29H2,(H,30,34)(H,31,32)/t22-,23-/m0/s1
InChIKey	QIFSPGPRHFNZNN-GOTSBHOMSA-N
Smiles	C1CCC(C1)OC(=O)CNC(=O)C(CSCC2=CC=C(C=C2)Br)NC(=O)CCC(C(=O)OC3CCCC3)N
Isomeric SMILES	C1CCC(C1)OC(=O)CNC(=O)[C@H](CSCC2=CC=C(C=C2)Br)NC(=O)CC[C@@H](C(=O)OC3CCCC3)N
PubChem CID	127939
Molecular Weight	612.58

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 250 mg/mL (408.11 mM; Need ultrasonic)
Molecular Weight	612.600 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	16
Exact Mass	611.166 Da
Monoisotopic Mass	611.166 Da
Topological Polar Surface Area	162.000 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	783.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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