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BOP, Antagonist of integrin α4β1;Antagonist of integrin; alpha 9 subunit, CAS No.217453-20-8, Antagonist of integrin α4β1;Antagonist of integrin; alpha 9 subunit

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Item Number
rp173588
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Price Qty
rp173588-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
rp173588-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,334.90

Basic Description

Product Name BOP, Antagonist of integrin α4β1;Antagonist of integrin; alpha 9 subunit, CAS No.217453-20-8
Synonyms compound 2;compound 3;N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine
Grade Moligand™
Specifications & Purity Moligand™
Action Type ANTAGONIST
Mechanism of action Antagonist of integrin α4β1;Antagonist of integrin; alpha 9 subunit

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Peptides
Direct Parent Dipeptides
Alternative Parents Phenylalanine and derivatives  Proline and derivatives  N-acyl-L-alpha-amino acids  Alpha amino acid amides  Phenylpropanoic acids  Amphetamines and derivatives  Benzenesulfonamides  Benzenesulfonyl compounds  Pyrrolidinecarboxamides  Pyrrolidine carboxylic acids  Phenoxy compounds  Organosulfonamides  Sulfonyls  Carbamate esters  Secondary carboxylic acid amides  Carboxylic acids  Azacyclic compounds  Monocarboxylic acids and derivatives  Carbonyl compounds  Organic oxides  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Alpha-dipeptide - Phenylalanine or derivatives - Proline or derivatives - N-acyl-alpha amino acid or derivatives - N-acyl-l-alpha-amino acid - N-acyl-alpha-amino acid - Alpha-amino acid amide - 3-phenylpropanoic-acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - Benzenesulfonamide - Benzenesulfonyl group - Phenoxy compound - Pyrrolidine carboxylic acid - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Monocyclic benzene moiety - Benzenoid - Organosulfonic acid amide - Pyrrolidine - Sulfonyl - Carbamic acid ester - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Organoheterocyclic compound - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxide - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
External Descriptors Not available

Associated Targets(Human)

ITGA4 Tclin Integrin alpha-4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGA9 Tbio Integrin alpha-9 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGB1 Tclin Integrin beta-1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGB1 Tclin Integrin alpha-4/beta-1 (2269 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Storage and Shipping

CAS 217453-20-8

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Genetic information

Alternate Names compound 2;compound 3;N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

Citations of This Product

1. Kai Feng, Yiling Ruan, Xinmiao Zhang, Xiaojing Wu, Zixuan Liu, Xiaolian Sun.  (2023)  Photothermal-Ionic-Pharmacotherapy of Myocardial Infarction with Enhanced Angiogenesis and Antiapoptosis.  ACS Applied Materials & Interfaces,     
2. Jia Zeng, Peng Sun, Xinning Fang, Yicheng Jiang, Zhenghong Wu, Xiaole Qi.  (2023)  “Shell-Core” Bilayer Nanoparticle as Chemotherapeutic Drug Co-Delivery Platforms Render Synchronized Microenvironment Respond and Enhanced Antitumor Effects.  International Journal of Nanomedicine,     
3. Kai-Xian Hu, Ze-Yong Zhao, Peng Lu, Shuang He, Cong Deng, Yu-Zhong Wang.  (2023)  Caffeic acid decorated ammonium polyphosphate-based flame retardant for fire safety and anti-aging of wood plastic composites.  POLYMER DEGRADATION AND STABILITY,  209  (110275). 
4. Jiangbo Guo, Yajuan Li, Yajun Zhang, Jujie Ren, Xudong Yu, Xinhua Cao.  (2021)  Switchable Supramolecular Configurations of Al3+/LysTPY Coordination Polymers in a Hydrogel Network Controlled by Ultrasound and Heat.  ACS Applied Materials & Interfaces,  13  (33): (40079–40087). 

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