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BMS-984923 - 99%, high purity , CAS No.1375752-78-5

COA

Grade & Purity:

Moligand™

≥99%

Cas Number: 1375752-78-5
Molecular Weight: 374.82
PubChem CID: 69084898

In stock

Item Number

B647879

Grouped product items
SKU	Size	Availability	Price	Qty
B647879-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$208.90
B647879-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$521.90

View related series

Class C GPCR (248) GPCR/G Protein (3172) mGluR (176) Neuronal Signaling (3320)

Basic Description

Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (K i = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo s
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Product Description	BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (K i = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling. In Vivo BMS-984923 (7.5 mg/kg or 15 mg/kg, oral gavage, once) exhibits good oral bioavailability and BBB penetration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl6J male mice . Dosage: 7.5 mg/kg or 15 mg/kg (Pharmacokinetic Analysis) Administration: Oral gavage, once. Result: The plasma concentration exceeded 2 μM at 10 hr. Brain concentrations were nearly as high as plasma concentrations when measured 3 hr after a 7.5 mg/kg oral dose Form:Solid

Associated Targets(Human)

GRM5 Tchem Metabotropic glutamate receptor 5 (1 Activities)

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Smiles	C1=CC=C(C=C1)C#CC2=CC(=CN=C2)[C@@H]3[C@H](OC(=O)N3)C4=CC=CC=C4Cl
Isomeric SMILES	C1=CC=C(C=C1)C#CC2=CC(=CN=C2)[C@@H]3[C@H](OC(=O)N3)C4=CC=CC=C4Cl
PubChem CID	69084898
Molecular Weight	374.82

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 50 mg/mL (133.40 mM; Need ultrasonic)
Sensitivity	Light sensitive，Moisture sensitive.

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