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BMS 303141 - 98%, high purity , CAS No.943962-47-8

COA

Grade & Purity:

≥98%

Cas Number: 943962-47-8
Molecular Weight: 424.3
PubChem CID: 16747776
PubChem SID: 488199424

In stock

Item Number

B288525

Grouped product items
SKU	Size	Availability	Price
B288525-5mg	5mg	3	$76.90
B288525-10mg	10mg	2	$99.90
B288525-25mg	25mg	1	$225.90
B288525-50mg	50mg	1	$355.90
B288525-100mg	100mg	1	$640.90
B288525-200mg	200mg	1	$1,153.90

ATP citrate lyase inhibitor

View related series

ATP Citrate Lyase (14) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	ATP citrate lyase (ACL) inhibitor (IC50= 0.13μM for human recombinant ACL); blocks lipid synthesis (IC50= 8μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidem
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Biphenyls and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Biphenyls and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Biphenyls and derivatives
Alternative Parents	Sulfanilides Benzenesulfonamides Benzenesulfonyl compounds Methoxyanilines Anisoles Phenoxy compounds P-chlorophenols Dichlorobenzenes Methoxybenzenes O-chlorophenols Alkyl aryl ethers Organosulfonamides Aryl chlorides Aminosulfonyl compounds Hydrocarbon derivatives Organic oxides Organochlorides Organonitrogen compounds Organopnictogen compounds
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Biphenyl - Sulfanilide - Benzenesulfonamide - Benzenesulfonyl group - Methoxyaniline - Phenoxy compound - Anisole - 2-chlorophenol - Methoxybenzene - 4-halophenol - 1,3-dichlorobenzene - 4-chlorophenol - Phenol ether - 2-halophenol - Halobenzene - Chlorobenzene - Alkyl aryl ether - Phenol - Aryl halide - Organosulfonic acid amide - Aryl chloride - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Ether - Organochloride - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organohalogen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACLY Tclin ATP-citrate synthase (3 Activities)

Discover Target: ACLY

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACACA Tchem Acetyl-CoA carboxylase 1 (794 Activities)

Discover Target: ACACA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACACB Tchem Acetyl-CoA carboxylase 2 (3474 Activities)

Discover Target: ACACB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACLY Tclin ATP-citrate synthase (168 Activities)

Discover Target: ACLY

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488199424
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488199424
IUPAC Name	3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide
INCHI	InChI=1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3
InChIKey	SIIPNDKXZOTLEA-UHFFFAOYSA-N
Smiles	COC1=C(C=C(C=C1)C2=CC=CC=C2)NS(=O)(=O)C3=C(C(=CC(=C3)Cl)Cl)O
Isomeric SMILES	COC1=C(C=C(C=C1)C2=CC=CC=C2)NS(=O)(=O)C3=C(C(=CC(=C3)Cl)Cl)O
Molecular Weight	424.3
Reaxy-Rn	11066789
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11066789&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
C2322294	Certificate of Analysis	Feb 24, 2023	B288525
C2322302	Certificate of Analysis	Feb 24, 2023	B288525
C2322303	Certificate of Analysis	Feb 24, 2023	B288525
C2322298	Certificate of Analysis	Feb 24, 2023	B288525
C2322293	Certificate of Analysis	Feb 24, 2023	B288525
C2322269	Certificate of Analysis	Feb 24, 2023	B288525
C2322301	Certificate of Analysis	Feb 24, 2023	B288525
C2322297	Certificate of Analysis	Feb 24, 2023	B288525
C2322292	Certificate of Analysis	Feb 24, 2023	B288525
C2322288	Certificate of Analysis	Feb 24, 2023	B288525
C2322291	Certificate of Analysis	Feb 24, 2023	B288525
C2322285	Certificate of Analysis	Feb 24, 2023	B288525

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 4.24, Max Conc. mM: 10; Solvent:ethanol, Max Conc. mg/mL: 21.21, Max Conc. mM: 50
Molecular Weight	424.300 g/mol
XLogP3	5.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	423.01 Da
Monoisotopic Mass	423.01 Da
Topological Polar Surface Area	84.000 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	579.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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BMS 303141 - 98%, high purity , CAS No.943962-47-8

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Show more⌵

Chemical and Physical Properties

Alternative Products

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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