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BMS 182874 hydrochloride - ≥98%(HPLC), high purity , CAS No.1215703-04-0

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 1215703-04-0
Molecular Weight: 381.88
PubChem CID: 56972163
PubChem SID: 504771516

In stock

Item Number

B286892

Grouped product items
SKU	Size	Availability	Price
B286892-5mg	5mg	3	$136.90
B286892-10mg	10mg	3	$209.90
B286892-25mg	25mg	2	$472.90
B286892-50mg	50mg	2	$864.90
B286892-100mg	100mg	2	$1,556.90

non-peptide ETAantagonist

View related series

Class A GPCR (4138)

Basic Description

Synonyms	5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide hydrochloride \| BMS182874 \| N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride \| 5-(dimethylamino)-N-(3,4-dimethylisoxazol-5-yl)naphthalene-1-sulf
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent, selective and competitive non-peptide endothelin ETAreceptor antagonist (Ki= 48 nM). Displays > 1000-fold selectivity over ETBreceptors. Inhibits ET-1-induced pressor response following oral or intravenous administrationin vivo. Inhibits ET-1-indu
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Product introduction BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Naphthalenes
    - Subclass Naphthalene sulfonic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Naphthalenes
Subclass	Naphthalene sulfonic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	1-naphthalene sulfonic acids and derivatives
Alternative Parents	1-naphthalene sulfonamides Dialkylarylamines Organosulfonamides Isoxazoles Heteroaromatic compounds Aminosulfonyl compounds Oxacyclic compounds Azacyclic compounds Organooxygen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	1-naphthalene sulfonic acid or derivatives - Naphthalene sulfonamide - 1-naphthalene sulfonamide - Dialkylarylamine - Organosulfonic acid amide - Azole - Isoxazole - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Heteroaromatic compound - Sulfonyl - Aminosulfonyl compound - Tertiary amine - Oxacycle - Azacycle - Organoheterocyclic compound - Amine - Hydrocarbon derivative - Organic oxide - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Hydrochloride - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 1-naphthalene sulfonic acids and derivatives. These are organic aromatic compounds that contain a naphthalene moiety that carries a sulfonic acid group (or a derivative thereof) at the 1-position. Naphthalene is a bicyclic compound that is made up of two fused benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504771516
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771516
IUPAC Name	5-(dimethylamino)-N-(3,4-dimethyl-1,2-oxazol-5-yl)naphthalene-1-sulfonamide;hydrochloride
INCHI	InChI=1S/C17H19N3O3S.ClH/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4;/h5-10,19H,1-4H3;1H
InChIKey	UZZFRNZGYDOBAO-UHFFFAOYSA-N
Smiles	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC3=C2C=CC=C3N(C)C.Cl
Isomeric SMILES	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC3=C2C=CC=C3N(C)C.Cl
Molecular Weight	381.88
Reaxy-Rn	35450642
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35450642&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
H2229183	Certificate of Analysis	Jun 09, 2025	B286892
H2229186	Certificate of Analysis	Jun 09, 2025	B286892
H2229181	Certificate of Analysis	Jun 09, 2025	B286892
H2229185	Certificate of Analysis	Jun 09, 2025	B286892
H2229182	Certificate of Analysis	Jun 09, 2025	B286892
L2418321	Certificate of Analysis	Jun 20, 2022	B286892

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: None, Max Conc. mM: 100
Molecular Weight	381.900 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	381.091 Da
Monoisotopic Mass	381.091 Da
Topological Polar Surface Area	83.800 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	534.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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