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BML-280 - 98%, high purity , CAS No.1158347-73-9

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BML-280 - 98%, high purity , CAS No.1158347-73-9

COA

Grade & Purity:

≥98%

Cas Number: 1158347-73-9
Molecular Weight: 429.5
PubChem CID: 44138050
PubChem SID: 504770278

In stock

Item Number

N130534

Grouped product items
SKU	Size	Availability	Price
N130534-1mg	1mg	3	$24.90
N130534-5mg	5mg	3	$95.90
N130534-10mg	10mg	3	$171.90
N130534-25mg	25mg	3	$384.90

Potent, selective PLD2 inhibitor

View related series

Apoptosis (4276) Extrinsic Pathway (436) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860) Phospholipase (108) TNF Receptor (121)

Basic Description

Synonyms	VU0285655-1 \| APV
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent, selective PLD2 inhibitor (IC 50 values are 90 and 500 nM for HEK293 and human cells respectively).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Quinoline carboxamides

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Quinoline carboxamides
Intermediate Tree Nodes	Not available
Direct Parent	Quinoline-3-carboxamides
Alternative Parents	Phenylimidazolidines Alpha amino acids and derivatives Azaspirodecane derivatives Pyridinecarboxylic acids and derivatives Aniline and substituted anilines Dialkylarylamines Piperidines Imidazolidinones Heteroaromatic compounds Trialkylamines Secondary carboxylic acid amides Lactams Azacyclic compounds Hydrocarbon derivatives Organic oxides Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinoline-3-carboxamide - Phenylimidazolidine - Alpha-amino acid or derivatives - Azaspirodecane - Pyridine carboxylic acid or derivatives - Dialkylarylamine - Aniline or substituted anilines - Monocyclic benzene moiety - Imidazolidinone - Piperidine - Pyridine - Benzenoid - Heteroaromatic compound - Imidazolidine - Secondary carboxylic acid amide - Tertiary aliphatic amine - Tertiary amine - Carboxamide group - Lactam - Amino acid or derivatives - Carboxylic acid derivative - Azacycle - Amine - Carbonyl group - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Organic oxide - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinoline-3-carboxamides. These are quinolines in which the quinoline ring system is substituted by one carboxamide group at the 3-position.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PLD1 Tchem Phospholipase D1 (469 Activities)

Discover Target: PLD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770278
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770278
IUPAC Name	N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide
INCHI	InChI=1S/C25H27N5O2/c31-23(20-16-19-6-4-5-9-22(19)27-17-20)26-12-15-29-13-10-25(11-14-29)24(32)28-18-30(25)21-7-2-1-3-8-21/h1-9,16-17H,10-15,18H2,(H,26,31)(H,28,32)
InChIKey	WJOCDBUFEUKYNI-UHFFFAOYSA-N
Smiles	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5N=C4
Isomeric SMILES	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5N=C4
Molecular Weight	429.5
Reaxy-Rn	19659942
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19659942&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
F2316558	Certificate of Analysis	Mar 04, 2025	N130534
F2316556	Certificate of Analysis	Mar 04, 2025	N130534
F2316511	Certificate of Analysis	Mar 04, 2025	N130534
F2316555	Certificate of Analysis	Mar 04, 2025	N130534
F2316552	Certificate of Analysis	Mar 04, 2025	N130534
F2316553	Certificate of Analysis	Mar 04, 2025	N130534
F2316559	Certificate of Analysis	Mar 04, 2025	N130534
F2316549	Certificate of Analysis	Mar 04, 2025	N130534

Chemical and Physical Properties

Molecular Weight	429.500 g/mol
XLogP3	2.900
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	429.216 Da
Monoisotopic Mass	429.216 Da
Topological Polar Surface Area	77.600 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	671.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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