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Bisphenol A Diglycidyl Ether - ≥85.0%(GC), high purity , CAS No.1675-54-3

En stock
Item Number
B131786
Articles du produit groupé
SKU Taille
Disponibilité
Prix Qté
B131786-25g
25g
1
22,90$US
B131786-100g
100g
2
37,90$US
B131786-500g
500g
1
67,90$US

Selective PPARγ antagonist

Description générale

Synonymes BADGE | 4,4'-Isopropylidenebis[1-(2,3-epoxypropoxy)benzene] | BISPHENOL A DIGLYCIDYL ETHER RESIN | BSPBio_001468 | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)propane | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-propane | Bio1_001356 | 2,2-Bis(p-hydroxyphenyl)propane dig
Spécifications et pureté Moligand™, ≥85%
Mécanismes biochimiques et physiologiques Selective PPARγ antagonist. Induces PPARγ-independent apoptosis of tumor cells. Increases osteoblastogenesis and bone mass in vivo.
Température de stockage Store at 2-8°C,Argon charged
Expédié en
Wet ice
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Grade Moligand™
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Bisphenol A Diglycidyl Ether is a diglycidyl ether (BADGE) can inhibit the peroxisome proliferator-activated receptor (PPARγ) and adipocyte differentiation, and has been shown to induce apoptosis in tumor cells. Research shows that BADGE can suppress the tumor necrosis factor-α (TNF-α) and that it has the ability to induce F-actin depolymerization.
An inhibitor of PPARγ and suppressor of TNFα.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Classe Benzene and substituted derivatives
Subclass Diphenylmethanes
Intermediate Tree Nodes Not available
Direct Parent Diphenylmethanes
Alternative Parents Phenylpropanes  Phenoxy compounds  Phenol ethers  Alkyl aryl ethers  Oxacyclic compounds  Epoxides  Dialkyl ethers  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Diphenylmethane - Phenylpropane - Phenoxy compound - Phenol ether - Alkyl aryl ether - Oxacycle - Organoheterocyclic compound - Ether - Oxirane - Dialkyl ether - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
External Descriptors diarylmethane

Cibles associées (humaines)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Cibles associées (non humaines)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
H4 (48 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mécanismes d'action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name Références

Noms et identifiants

IUPAC Name 2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane
INCHI InChI=1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3
InChIKey LCFVJGUPQDGYKZ-UHFFFAOYSA-N
Smiles CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
Isomères SMILES CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
RTECS TX3800000
Poids moléculaire 340.42
Reaxy-Rn 299026
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=299026&ln=

Certificats (CoA, COO, BSE/TSE et tableau d'analyse)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

31 results found

Lot Number Certificate Type Date Article
D2525159 Certificate of Analysis Apr 18, 2025 B131786
D2525161 Certificate of Analysis Apr 18, 2025 B131786
D2525162 Certificate of Analysis Apr 18, 2025 B131786
D2525160 Certificate of Analysis Apr 18, 2025 B131786
F2313781 Certificate of Analysis Mar 05, 2025 B131786
F2313801 Certificate of Analysis Mar 05, 2025 B131786
K2418173 Certificate of Analysis Sep 29, 2024 B131786
K2418176 Certificate of Analysis Sep 29, 2024 B131786
K2418174 Certificate of Analysis Sep 29, 2024 B131786
K2418175 Certificate of Analysis Sep 29, 2024 B131786
J2414746 Certificate of Analysis Sep 28, 2024 B131786
J2414861 Certificate of Analysis Sep 28, 2024 B131786
J2414744 Certificate of Analysis Sep 28, 2024 B131786
J2414740 Certificate of Analysis Sep 28, 2024 B131786
J2414741 Certificate of Analysis Sep 28, 2024 B131786
C2414139 Certificate of Analysis Feb 28, 2024 B131786
C2414140 Certificate of Analysis Feb 28, 2024 B131786
H2405029 Certificate of Analysis Jun 01, 2023 B131786
F2313782 Certificate of Analysis Jun 01, 2023 B131786
F2313785 Certificate of Analysis Jun 01, 2023 B131786
D2307489 Certificate of Analysis Jan 12, 2023 B131786
D2307490 Certificate of Analysis Jan 12, 2023 B131786
D2307491 Certificate of Analysis Jan 12, 2023 B131786
L22141011 Certificate of Analysis Nov 21, 2022 B131786
L22141012 Certificate of Analysis Nov 21, 2022 B131786
L2215044 Certificate of Analysis Nov 21, 2022 B131786
L22141014 Certificate of Analysis Nov 21, 2022 B131786
D2214004 Certificate of Analysis Mar 07, 2022 B131786
D2214002 Certificate of Analysis Mar 07, 2022 B131786
D2214005 Certificate of Analysis Mar 07, 2022 B131786
D2214003 Certificate of Analysis Mar 07, 2022 B131786

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Propriétés chimiques et physiques

Solubilité Soluble in 100% ethanol, DMSO (100 mM), DMF, chloroform, methanol, and ethanol (50 mM). Insoluble in PBS, pH 7.2, and water.
Sensibilité Heat & Moisture Sensitive.
Indice de réfraction 1.57
Point d'ébullition (°C) 210 °C/1 mmHg
Poids moléculaire 340.400 g/mol
XLogP3 4.000
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 8
Exact Mass 340.167 Da
Monoisotopic Mass 340.167 Da
Topological Polar Surface Area 43.500 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 384.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 2
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

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