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Bisindolylmaleimide II - ≥97%, high purity , CAS No.137592-45-1

    Grade & Purity:
  • ≥97%
In stock
Item Number
B276515
Grouped product items
SKU Size
Availability
Price Qty
B276515-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$185.90
B276515-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$546.90

Potent, selective ATP-competitive PKC inhibitor. Potent noncompetitive nAChR antagonist.

Basic Description

Synonyms Bisindolyl deriv. 22 | 2-[1-[2-(1-Methylpyrrolidino)ethyl]-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide | SCHEMBL7978085 | bisindolylmaleimide ii | 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione | 3-(1H-indol-3-
Specifications & Purity ≥97%
Biochemical and Physiological Mechanisms Potent, selective ATP-competitive PKC inhibitor (IC 50 values are 0.01, 0.75 and 2 μM for PKC, phosphorylase kinase and PKA respectively).
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Indoles and derivatives
Subclass N-alkylindoles
Intermediate Tree Nodes Not available
Direct Parent N-alkylindoles
Alternative Parents Indoles  Maleimides  Benzenoids  Substituted pyrroles  N-alkylpyrrolidines  Dicarboximides  Heteroaromatic compounds  Pyrrolines  N-unsubstituted carboxylic acid imides  Amino acids and derivatives  Trialkylamines  Azacyclic compounds  Hydrocarbon derivatives  Organopnictogen compounds  Organic oxides  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents N-alkylindole - Indole - Maleimide - Substituted pyrrole - N-alkylpyrrolidine - Benzenoid - Carboxylic acid imide - Dicarboximide - Carboxylic acid imide, n-unsubstituted - Pyrrole - Pyrrolidine - Pyrroline - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Amino acid or derivatives - Carboxylic acid derivative - Azacycle - Amine - Organic oxide - Carbonyl group - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
External Descriptors Not available

Associated Targets(Human)

CAMK2D Tchem CaM kinase II delta (2813 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SIRT2 Tchem NAD-dependent deacetylase sirtuin 2 (3979 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione
INCHI InChI=1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
InChIKey LBFDERUQORUFIN-UHFFFAOYSA-N
Smiles CN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
Isomeric SMILES CN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
Molecular Weight 438.52
Reaxy-Rn 9235277
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9235277&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Soluble in DMSO to 100 mM
Molecular Weight 438.500 g/mol
XLogP3 3.700
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 5
Exact Mass 438.206 Da
Monoisotopic Mass 438.206 Da
Topological Polar Surface Area 70.100 Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 825.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

Reviews

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