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BIP-135 , CAS No.941575-71-9

Grade & Purity:

≥98%

Cas Number: 941575-71-9
Molecular Weight: 421.24
PubChem CID: 16741475

In stock

Item Number

B338804

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SKU	Size	Availability	Price
B338804-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$48.90
B338804-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$115.90
B338804-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$187.90
B338804-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$369.90
B338804-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90

a GSK-3 inibitor with modest efficacy against PKC and PI3K

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GSK-3 (104) PI3K/Akt/mTOR (765) Stem Cell/Wnt (1019)

Synonyms	3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione \| AKOS016362524 \| bip-135 \| 3-Benzofuran-3-yl-4-(5-bromo-1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione \| QKQJCKAXFJBYKJ-UHFFFAOYSA-N \| F82200 \| HY-111055 \| 3-(1-benzofuran-3-yl)-4-(5-brom
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	BIP-135 is an inhibitor of glycogen synthase kinase-3 (GSK-3), and is found to be realatively selective for GSK-3β at 21 nM over GSK-3α with modest activity toward PKCβ (β1: 980 nM; β2: 219 nM), DYRK1B (590 nM), and PI3Kα (870 nM). BIP-135 was shown to have neuroprotective effects over cortical neuron model of oxidative stress. In a mouse model of spinal muscular atrophy, BIP-135 elevated SMN protein levels in vitro and extended median survival.

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	N-alkylindoles
Intermediate Tree Nodes	Not available
Direct Parent	N-alkylindoles
Alternative Parents	Indoles Benzofurans Maleimides Aryl bromides Benzenoids N-methylpyrroles Pyrrolines N-unsubstituted carboxylic acid imides Heteroaromatic compounds Furans Dicarboximides Oxacyclic compounds Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organobromides Organonitrogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-alkylindole - Benzofuran - Indole - Maleimide - Aryl bromide - Aryl halide - Benzenoid - Substituted pyrrole - N-methylpyrrole - Carboxylic acid imide - Heteroaromatic compound - Dicarboximide - Furan - Pyrroline - Pyrrole - Carboxylic acid imide, n-unsubstituted - Carboxylic acid derivative - Oxacycle - Azacycle - Organooxygen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organonitrogen compound - Organobromide - Organohalogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

IUPAC Name	3-(1-benzofuran-3-yl)-4-(5-bromo-1-methylindol-3-yl)pyrrole-2,5-dione
INCHI	InChI=1S/C21H13BrN2O3/c1-24-9-14(13-8-11(22)6-7-16(13)24)18-19(21(26)23-20(18)25)15-10-27-17-5-3-2-4-12(15)17/h2-10H,1H3,(H,23,25,26)
InChIKey	QKQJCKAXFJBYKJ-UHFFFAOYSA-N
Smiles	CN1C=C(C2=C1C=CC(=C2)Br)C3=C(C(=O)NC3=O)C4=COC5=CC=CC=C54
Isomeric SMILES	CN1C=C(C2=C1C=CC(=C2)Br)C3=C(C(=O)NC3=O)C4=COC5=CC=CC=C54
WGK Germany	3
Molecular Weight	421.24
Reaxy-Rn	11112620
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11112620&ln=

Solubility	DMSO : 62.5 mg/mL (148.37 mM; 超声助溶）
Refractive Index	n20D1.75 (Predicted)
Boil Point(°C)	~643.5° C at 760 mmHg (Predicted)
Melt Point(°C)	300.49° C (Predicted)
Molecular Weight	421.200 g/mol
XLogP3	3.700
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	420.011 Da
Monoisotopic Mass	420.011 Da
Topological Polar Surface Area	64.200 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	693.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

BIP-135 , CAS No.941575-71-9

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