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Bilirubin - 98%, high purity , CAS No.635-65-4

44 Citations COA COA
In stock
Item Number
B104211
Grouped product items
SKU Size
Availability
 Price Qty
B104211-100mg
100mg
≥10
$24.90
B104211-250mg
250mg
10
$46.90
B104211-1g
1g
8
$143.90
B104211-5g
5g
2
$535.90
B104211-25g
25g
1
$2,014.90
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Basic Description

Synonyms AKOS015895627 | BSPBio_002531 | EINECS 211-239-7 | HY-N0323 | 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate | 3-(2-((3-(2-carboxyethyl)-4-methyl-5-((Z)-(3-methyl-5-oxo-4-vinyl-1H-pyrrol-2(5H)-ylide
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Well over 99% of total bilirubin is transported as a conjugate with albumin. Abnormally high levels of bilirubin can cause severe neurological damage, but mildly elevated levels are linked to protection from oxidative stress.
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Product Description

Bilirubin is a principal pigment of bile and one of the major end products of hemoglobin decomposition. It contains conjugated double bonds and reactive hydrogen atoms. Serves as a physiological antioxidant. Reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This product corresponds to the unconjugated form. Extinction coefficient (454 nm, CHCl3):59,100-62,300 M-1cm-1.
A principal pigment of bile and one of the major end products of hemoglobin decomposition

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Tetrapyrroles and derivatives
Subclass Bilirubins
Intermediate Tree Nodes Not available
Direct Parent Bilirubins
Alternative Parents Substituted pyrroles  Dicarboxylic acids and derivatives  Pyrrolines  Heteroaromatic compounds  Secondary carboxylic acid amides  Lactams  Carboxylic acids  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Bilirubin skeleton - Dicarboxylic acid or derivatives - Substituted pyrrole - Pyrrole - Pyrroline - Heteroaromatic compound - Secondary carboxylic acid amide - Lactam - Carboxamide group - Azacycle - Carboxylic acid - Carboxylic acid derivative - Organopnictogen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as bilirubins. These are organic compounds containing a dicarboxylic acyclic tetrapyrrole derivative.
External Descriptors dicarboxylic acid - biladienes

Associated Targets(Human)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CASP1 Tchem Caspase-1 (6235 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CASP7 Tchem Caspase-7 (3146 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Caco-2 (12174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 (787 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT2B17 Tbio UDP-glucuronosyltransferase 2B17 (197 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1A2 Tchem Solute carrier organic anion transporter family member 1A2 (104 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 (221 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 (343 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488195199
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195199
IUPAC Name 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
INCHI InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
InChIKey BPYKTIZUTYGOLE-IFADSCNNSA-N
Smiles CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)C=C3C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)C=C4C(=C(C(=O)N4)C=C)C
Isomeric SMILES CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)/C=C\3/C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)/C=C\4/C(=C(C(=O)N4)C=C)C
WGK Germany 2
RTECS DU3038000
Molecular Weight 584.66
Beilstein 74376
Reaxy-Rn 1236109
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1236109&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
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27 results found

Lot Number Certificate Type Date Item
B2506385 Certificate of Analysis Dec 09, 2024 B104211
B2514423 Certificate of Analysis Dec 09, 2024 B104211
B2514424 Certificate of Analysis Dec 09, 2024 B104211
B2506366 Certificate of Analysis Dec 09, 2024 B104211
F2516043 Certificate of Analysis Dec 09, 2024 B104211
H2421128 Certificate of Analysis Nov 14, 2022 B104211
F2404078 Certificate of Analysis Nov 14, 2022 B104211
B2327110 Certificate of Analysis Nov 14, 2022 B104211
L2314033 Certificate of Analysis Nov 14, 2022 B104211
I2425078 Certificate of Analysis Nov 14, 2022 B104211
B2327085 Certificate of Analysis Nov 14, 2022 B104211
B2327094 Certificate of Analysis Nov 14, 2022 B104211
B2327092 Certificate of Analysis Nov 14, 2022 B104211
B2327086 Certificate of Analysis Nov 14, 2022 B104211
B2327120 Certificate of Analysis Nov 14, 2022 B104211
B2327087 Certificate of Analysis Nov 14, 2022 B104211
J2409089 Certificate of Analysis Nov 14, 2022 B104211
B2327095 Certificate of Analysis Nov 14, 2022 B104211
L2306098 Certificate of Analysis Jul 12, 2022 B104211
H2223045 Certificate of Analysis Jul 12, 2022 B104211
H2223043 Certificate of Analysis Jul 12, 2022 B104211
H2223253 Certificate of Analysis Jul 12, 2022 B104211
H2223109 Certificate of Analysis Jul 12, 2022 B104211
H2223252 Certificate of Analysis Jul 12, 2022 B104211
A2409171 Certificate of Analysis Jun 07, 2022 B104211
A2409172 Certificate of Analysis Jun 07, 2022 B104211
G2205154 Certificate of Analysis May 18, 2021 B104211

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Chemical and Physical Properties

Solubility Soluble in chloroform (10 mg/ml), benzene, chlorobenzene, carbon disulfide, alkaline solutions, aqueous acid, ethanol (slightly), and ether (slightly). Insoluble in water.
Sensitivity Light & Heat & Air sensitive
Refractive Index 1.72
Boil Point(°C) 925.16°C/760mmHg
Melt Point(°C) 192°C
Molecular Weight 584.700 g/mol
XLogP3 2.900
Hydrogen Bond Donor Count 6
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 12
Exact Mass 584.263 Da
Monoisotopic Mass 584.263 Da
Topological Polar Surface Area 164.000 Ų
Heavy Atom Count 43
Formal Charge 0
Complexity 1340.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 2
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 2
Covalently-Bonded Unit Count 1

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Wan Zhou, Wenbin Hu, Qiancheng Zhan, Minjun Zhang, Xinjie Liu, Wajid Hussain, Huibin Yu, Shenqi Wang, Lei Zhou.  (2023)  Novel hemoperfusion adsorbents based on collagen for efficient bilirubin removal – A thought from yellow skin of patients with hyperbilirubinemia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  253  (127321). 
2. Huimin Zhou, Anni Zhu, Caiyin Wang, Xiaoyu Guo, Ye Ying, Yiping Wu, Xinling Liu, Feng Wang, Ying Wen, Haifeng Yang.  (2024)  Preparation of gold nanoparticles loaded MOF-199 for SERS detection of 5-hydroxyindole-3-acetic acid in serum.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  304  (123280). 
3. Jingyu Xiao, Yanxia Chen, Tailin Xu, Xueji Zhang.  (2024)  Hand-held Raman spectrometer-based flexible plasmonic biosensor for label-free multiplex urinalysis.  TALANTA,  266  (124966). 
4. Ying Xu, Chenguang Hu, Jiayu liu, Haoran Guo, Jingkai Gao, Chi Wang, Chengbin Wang.  (2023)  Detection of synovial fluid LTF and S100A8 by chemiluminescence immunoassay for the diagnosis of periprosthetic joint infection.  CLINICA CHIMICA ACTA,  545  (117369). 
5. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479). 
6. Weimin Kong, Xueying Sun, Siyu Yu, Peihua Liu, Xiaoke Zheng, Jiaxin Zhang, Liang Zhu, Tianxin Jiang, Mengmeng Jin, Jinghui Gao, Xiaomin Fan, Xiaodong Liu, Li Liu.  (2023)  Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase.  BRITISH JOURNAL OF PHARMACOLOGY,  180  (13): (1690-1709). 
7. Liu Muhua, Zhang Wen, Zhang Panpan, Yuan Ling, Li Hao, Zhan Jinjie, Zhao Wenjun, Mei Xi.  (2023)  Enhanced Hemocompatibility of Lysine Grafted Polyacrylonitrile Electrospun Nanofiber Membranes as a Potential Bilirubin Adsorption in Hemoperfusion.  JOURNAL OF POLYMERS AND THE ENVIRONMENT,  31  (4): (1553-1567). 
8. Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu.  (2022)  Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood–Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (14): (7666). 
9. Yilin Wang, Shanshan Wang, Xueqin He, Yupei Li, Tao Xu, Lin Xu, Bo Yang, Xinnian Fan, Weifeng Zhao, Changsheng Zhao.  (2023)  A breakthrough trial of an artificial liver without systemic heparinization in hyperbilirubinemia beagle models.  Bioactive Materials,  20  (651). 
10. Yaotian Peng, Xiaoyan Feng, Jianming Jiang, Li Ren.  (2022)  Controllable polyvinylpyrrolidone modified Polystyrene divinylbenzene for efficient adsorption of bilirubin and improvement of hemocompatibility.  EUROPEAN POLYMER JOURNAL,  170  (111172). 
11. Mei Jianfeng, Wu Xia, Zheng Sujing, Yi Yu, Wang Xudong, Ying Guoqing.  (2022)  Production of bilirubin by biotransformation of biliverdin using recombinant Escherichia coli cells.  BIOPROCESS AND BIOSYSTEMS ENGINEERING,  45  (3): (563-571). 
12. Kangle Yang, Yaotian Peng, Lin Wang, Li Ren.  (2021)  Polymyxin B engineered polystyrene-divinylbenzene microspheres for the adsorption of bilirubin and endotoxin.  RSC Advances,  11  (63): (39978-39984). 
13. Chengli Zhang, Xun You, Yuliang Li, Yuanyuan Zuo, Wei Wang, DanDan Li, ShengWei Huang, Hangzhi Hu, Feng Yuan, Fuqiang Shao, Minggang Yin.  (2022)  A novel electrochemical aptasensor for serum dopamine detection based on methylene blue-integrated m-PdNFs signal material.  SENSORS AND ACTUATORS B-CHEMICAL,  354  (131233). 
14. Jie Zhou, Xueliang Wang, Jiajie Chen, Youjun Zeng, Dayong Gu, Bruce Zhi Gao, Yonghong Shao.  (2022)  Polymeric microsphere enhanced surface plasmon resonance imaging immunosensor for occult blood monitoring.  SENSORS AND ACTUATORS B-CHEMICAL,  350  (130858). 
15. Li Xiaowei, Zhang Haiyang, Dong Jing, Ma Shujuan, Ou Junjie.  (2021)  One-pot synthesis of glucose-derived carbonaceous material with high hydrophilicity and adsorption capacity as bilirubin adsorbent.  JOURNAL OF MATERIALS SCIENCE,  56  (32): (18006-18018). 
16. Qiao Liangzhi, Wang Shanshan, Du Kaifeng.  (2021)  Macroporous cellulose/carbon nanotube microspheres prepared by surfactant micelle swelling strategy for rapid and high-capacity adsorption of bilirubin.  CELLULOSE,  28  (13): (8419-8428). 
17. Chunrong Li, Yuzhi Xu, Si-Yang Liu, Yanfei Zhang, Wen Yin, Zong Dai, Xiaoyong Zou.  (2021)  Cancer cell identification by facile imaging of intracellular reductive substances with fluorescent nanosensor.  TALANTA,  234  (122650). 
18. Zhi-Wei Huang, Yannan Shi, Yuan-Yuan Zhai, Chu-Chu Du, Jiaoyuan Zhai, Run-Jie Yu, Longfa Kou, Jian Xiao, Ying-Zheng Zhao, Qing Yao.  (2021)  Hyaluronic acid coated bilirubin nanoparticles attenuate ischemia reperfusion-induced acute kidney injury.  JOURNAL OF CONTROLLED RELEASE,  334  (275). 
19. Ying-Zheng Zhao, Zhi-Wei Huang, Yuan-Yuan Zhai, Yannan Shi, Chu-Chu Du, Jiaoyuan Zhai, He-Lin Xu, Jian Xiao, Longfa Kou, Qing Yao.  (2021)  Polylysine-bilirubin conjugates maintain functional islets and promote M2 macrophage polarization.  Acta Biomaterialia,  122  (172). 
20. Zhan-Jun Lu, Yarong Cheng, Yuan Zhang, Xuefeng Wang, Pengcheng Xu, Haitao Yu, Xinxin Li.  (2021)  Non-enzymatic free bilirubin electrochemical sensor based on ceria nanocube.  SENSORS AND ACTUATORS B-CHEMICAL,  329  (129224). 
21. Liangzhi Qiao, Yaling Li, Yi Liu, Yinghong Wang, Kaifeng Du.  (2020)  High-strength, blood-compatible, and high-capacity bilirubin adsorbent based on cellulose-assisted high-quality dispersion of carbon nanotubes.  JOURNAL OF CHROMATOGRAPHY A,  1634  (461659). 
22. Yi Xiao, Suhua Chen, Guocan Zhang, Zhimao Li, Han Xiao, Chuanpin Chen, Chunlian He, Ran Zhang, Xiaoping Yang.  (2020)  Simple and rapid nicotine analysis using a disposable silica nanochannel-assisted electrochemiluminescence sensor.  ANALYST,  145  (14): (4806-4814). 
23. Xiang Pan, Linhu Li, Hangduo Lin, Jiayi Tan, Haitao Wang, Mengling Liao, Caiju Chen, Beibei Shan, Yingfan Chen, Ming Li.  (2019)  A graphene oxide-gold nanostar hybrid based-paper biosensor for label-free SERS detection of serum bilirubin for diagnosis of jaundice.  BIOSENSORS & BIOELECTRONICS,  145  (111713). 
24. Shuai Wang, Yanke Lin, Ziyue Zhou, Lu Gao, Zemin Yang, Feng Li, Baojian Wu.  (2019)  Circadian Clock Gene Bmal1 Regulates Bilirubin Detoxification: A Potential Mechanism of Feedback Control of Hyperbilirubinemia.  Theranostics,  9  (18): ( 5122–5133). 
25. Jukai Zhou, Shuqing Zhang, Xin Song, Ran Wei, Xiang Zhang, Weifeng Zhao, Changsheng Zhao.  (2019)  Three-Dimensional Graphene Oxide Skeleton Guided Poly(acrylic Acid) Composite Hydrogel Particles with Hierarchical Pore Structure for Hemoperfusion.  ACS Biomaterials Science & Engineering,  5  (8): (3987–4001). 
26. Yanke Lin, Shuai Wang, Zemin Yang, Lu Gao, Ziyue Zhou, Pei Yu, Baojian Wu.  (2019)  Bilirubin alleviates alum–induced peritonitis through inactivation of NLRP3 inflammasome.  BIOMEDICINE & PHARMACOTHERAPY,  116  (108973). 
27. Zhou Li, Wenxiang Xiao, Rongen Huang, Yajing Shi, Cheng Fang, Zhencheng Chen.  (2019)  A Gold Nanoclusters Film Supported on Polydopamine for Fluorescent Sensing of Free Bilirubin.  SENSORS,  19  (7): (1726). 
28. Yang Facui, Tao Fei, Li Chen, Gao Lingxiang, Yang Peng.  (2018)  Self-assembled membrane composed of amyloid-like proteins for efficient size-selective molecular separation and dialysis.  Nature Communications,  9  (1): (1-11). 
29. Baoxia Liu, Haoshuang Shen, Yuanqiang Hao, Xu Zhu, Suzhi Li, Yankai Huang, Peng Qu, Maotian Xu.  (2018)  Lanthanide Functionalized Metal–Organic Coordination Polymer: Toward Novel Turn-On Fluorescent Sensing of Amyloid β-Peptide.  ANALYTICAL CHEMISTRY,  90  (21): (12449–12455). 
30. Zhipeng Yuan, Yansheng Li, Dan Zhao, Kexin Zhang, Fang Wang, Changtao Wang, Yongqiang Wen.  (2018)  High efficiency 3D nanofiber sponge for bilirubin removal used in hemoperfusion.  COLLOIDS AND SURFACES B-BIOINTERFACES,  172  (161). 
31. Zhi-yuan Lin, Yi-zhen Fang, Hong-wei Jin, Hua-yue Lin, Zhang Dai, Qing Luo, Hong-wei Li, Yan-ling Lin, Shui-zhen Huang, Lei Gao, Fei-hai Xu, Zhong-ying Zhang.  (2018)  Performance evaluation of a chemiluminescence microparticle immunoassay for CK-MB.  JOURNAL OF CLINICAL LABORATORY ANALYSIS,  32  (6): (e22426). 
32. Xue Qin, Cao Xuanyu, Zhang Cuiling, Xian Yuezhong.  (2018)  Polydopamine nanodots are viable probes for fluorometric determination of the activity of alkaline phosphatase via the in situ regulation of a redox reaction triggered by the enzyme.  MICROCHIMICA ACTA,  185  (4): (1-9). 
33. Jingkun Wang, Yizhen Fang, Peihua Li, Huayue Lin, Hongwei Jin, Lei Gao, Shengxiang Ge, Zhong-Ying Zhang.  (2017)  Evaluation of a newly developed chemiluminescence immunoassay for detecting cardiac troponin T.  JOURNAL OF CLINICAL LABORATORY ANALYSIS,  32  (3): (e22311). 
34. Yuqin Wu, Hongmei Zhang, Yanqing Wang.  (2017)  Conformational and functional changes of bovine serum albumin induced by TiO2 nanoparticles binding.  JOURNAL OF MOLECULAR LIQUIDS,  243  (358). 
35. Tao Guiju, Bai Zhengyuan, Chen Yu, Yao Heliang, Wu Meiying, Huang Ping, Yu Luodan, Zhang Jiamin, Dai Chen, Zhang Long.  (2017)  Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures.  Nano Research,  10  (11): (3790-3810). 
36. Wenwen Wang, Hao Zhang, Zhifeng Zhang, Mengying Luo, Yuedan Wang, Qiongzhen Liu, Yuanli Chen, Mufang Li, Dong Wang.  (2017)  Amine-functionalized PVA-co-PE nanofibrous membrane as affinity membrane with high adsorption capacity for bilirubin.  COLLOIDS AND SURFACES B-BIOINTERFACES,  150  (271). 
37. Jiang Xin, Xiang Tao, Xie Yi, Wang Rui, Zhao Weifeng, Sun Shudong, Zhao Chang-Sheng.  (2016)  Functional polyethersulfone particles for the removal of bilirubin.  JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,  27  (2): (1-12). 
38. Rui Wang, Tao Xiang, Wei-Feng Zhao, Chang-Sheng Zhao.  (2016)  A facile approach toward multi-functional polyurethane/polyethersulfone composite membranes for versatile applications.  Materials Science & Engineering C-Materials for Biological Applications,  59  (556). 
39. Guifang Du, Xiaomei Yang, Mu Hu, Chengcheng Hao, Yanan Gu, Xiuyi Zhi, Wen G. Jiang, Junqi He, Shan Cheng.  (2015)  Designing a novel high-throughput AlphaLISA assay to quantify plasma NHERF1 as a non-small cell lung cancer biomarker.  RSC Advances,  5  (102): (84164-84171). 
40. Jialin Qin, Yuanli Li, Chenxiong He, Xiaolan Yang, Yanling Xie, Xiaolei Hu, Chunyan Chen, Lu Wang, Jun Pu, Fei Liao.  (2014)  Selective and sensitive homogenous assay of serum albumin with 1-anilinonaphthalene-8-sulphonate as a biosensor.  ANALYTICA CHIMICA ACTA,  829  (60). 
41. Tingting Wen, Wanying Zhu, Cheng Xue, Jinhua Wu, Qing Han, Xi Wang, Xuemin Zhou, Huijun Jiang.  (2014)  Novel electrochemical sensing platform based on magnetic field-induced self-assembly of Fe3O4@Polyaniline nanoparticles for clinical detection of creatinine.  BIOSENSORS & BIOELECTRONICS,  56  (180). 
42. Bao-Ying Wen, Jing-Wen Zhou, Wen-Xiang Jiang, Yue-Jiao Zhang, Jian-Feng Li.  (2025)  A novel SERRS approach for the highly sensitive detection of bilirubin levels in urine.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  335  (125993). 
43. Xiangxian Li, Hengfeng Zhu, Xuanru Wei, Quanling Yang, Chuanxi Xiong, Zhuqun Shi.  (2025)  Nanocellulose/activated carbon composite aerogel beads with high adsorption capacity for toxins in blood.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  300  (140279). 
44. Lingyan Gui, Xu Teng, Ye Yang, Tao Liu, Yaru Liang, Jun Zeng, Xianying Zhang, Linhai Li.  (2025)  Real-time monitoring and multicolor visual analysis of hydrogen peroxide based on antenna effect-induced dual signal amplification strategy.  SENSORS AND ACTUATORS B-CHEMICAL,  432  (137486). 

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