Skip to the beginning of the images gallery

BF-168 - 99%, high purity , CAS No.634911-47-0

COA

Grade & Purity:

≥99%

Cas Number: 634911-47-0
Molecular Weight: 312.34
PubChem CID: 10244995

In stock

Item Number

B651875

Grouped product items
SKU	Size	Availability	Price
B651875-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$380.90
B651875-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
B651875-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,150.90
B651875-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,800.90
B651875-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,850.90

View related series

Amyloid-β (136) Neuronal Signaling (3320)

Basic Description

Synonyms	HY-112830 \| BF 168 \| BF-168 \| 6-(2-fluoroethoxy)-2-(2-(4-methylaminophenil)ethenyl)benzoxazole \| SCHEMBL989597 \| 4-[(E)-2-[6-(2-Fluoroethoxy)-1,3-benzoxazol-2-yl]ethenyl]-N-methylaniline \| 6-(2-fluoroethoxy)-2-[2-(4-methylaminophenyl)ethenyl] benzo-xazole
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42 .
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42 . In Vitro BF-168, a styrylbenzoxazole derivative, is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice result in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18 F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t 1/2 =24.7 min) after intravenous administration in normal mice. Furthermore, autoradiograms of brain sections from APP23 transgenic mice at 180 min after intravenous injection of [ 18 F]BF-168 shows selective labeling of brain amyloid deposits with little nonspecific binding . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 6.4 nM (Aβ1-42)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzoxazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzoxazoles
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Benzoxazoles
Alternative Parents	Styrenes Phenylalkylamines Phenol ethers Aniline and substituted anilines Secondary alkylarylamines Alkyl aryl ethers Oxazoles Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Organofluorides Hydrocarbon derivatives Alkyl fluorides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzoxazole - Phenol ether - Styrene - Aniline or substituted anilines - Phenylalkylamine - Alkyl aryl ether - Secondary aliphatic/aromatic amine - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Oxazole - Azole - Oxacycle - Secondary amine - Azacycle - Ether - Hydrocarbon derivative - Organofluoride - Organohalogen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as benzoxazoles. These are organic compounds containing a benzene fused to an oxazole ring Oxazole is five-membered aromatic ring with a nitrogen and an oxygen atoms at the 1- and 3-position, respectively.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	4-[(E)-2-[6-(2-fluoroethoxy)-1,3-benzoxazol-2-yl]ethenyl]-N-methylaniline
INCHI	InChI=1S/C18H17FN2O2/c1-20-14-5-2-13(3-6-14)4-9-18-21-16-8-7-15(22-11-10-19)12-17(16)23-18/h2-9,12,20H,10-11H2,1H3/b9-4+
InChIKey	FJCPWUDGNYOGQR-RUDMXATFSA-N
Smiles	CNC1=CC=C(C=C1)C=CC2=NC3=C(O2)C=C(C=C3)OCCF
Isomeric SMILES	CNC1=CC=C(C=C1)/C=C/C2=NC3=C(O2)C=C(C=C3)OCCF
Alternate CAS	634911-47-0
PubChem CID	10244995
MeSH Entry Terms	6-(2-fluoroethoxy)-2-(2-(4-methylaminophenil)ethenyl)benzoxazole;BF 168;BF-168;BF168 cpd
Molecular Weight	312.34

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 50 mg/mL (160.08 mM; Need ultrasonic)
Molecular Weight	312.300 g/mol
XLogP3	4.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	312.127 Da
Monoisotopic Mass	312.127 Da
Topological Polar Surface Area	47.300 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	385.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration