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BC 11 hydrobromide - 98%, high purity , CAS No.443776-49-6

COA

Grade & Purity:

≥98%

Cas Number: 443776-49-6
Molecular Weight: 290.97
PubChem CID: 78243712

In stock

Item Number

B274990

Grouped product items
SKU	Size	Availability	Price
B274990-5mg	5mg	2	$79.90
B274990-10mg	10mg	2	$156.90
B274990-25mg	25mg	2	$312.90
B274990-50mg	50mg	1	$519.90
B274990-100mg	100mg	1	$839.90

Selective urokinase (uPA) inhibitor

View related series

Amino Acid/Protein Metabolism (1836) Proteases (14) Urokinase Inhibitors (1) Virus (1811)

Basic Description

Synonyms	Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective urokinase (uPA) inhibitor (IC 50 = 8.2 μM). Shows selectivity over 8 other related enzymes.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	BC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Benzene and substituted derivatives
Alternative Parents	Isothioureas Boronic acids Sulfenyl compounds Organic metalloid salts Carboximidamides Organometalloid compounds Organic oxygen compounds Imines Hydrocarbon derivatives Hydrobromides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Monocyclic benzene moiety - Boronic acid derivative - Boronic acid - Isothiourea - Organic metalloid salt - Sulfenyl compound - Carboximidamide - Organic nitrogen compound - Organosulfur compound - Organonitrogen compound - Organic metalloid moeity - Hydrobromide - Imine - Hydrocarbon derivative - Organic oxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	[4-(carbamimidoylsulfanylmethyl)phenyl]boronic acid;hydrobromide
INCHI	InChI=1S/C8H11BN2O2S.BrH/c10-8(11)14-5-6-1-3-7(4-2-6)9(12)13;/h1-4,12-13H,5H2,(H3,10,11);1H
InChIKey	PAFZAMOVHIRQOD-UHFFFAOYSA-N
Smiles	B(C1=CC=C(C=C1)CSC(=N)N)(O)O.Br
Isomeric SMILES	B(C1=CC=C(C=C1)CSC(=N)N)(O)O.Br
Molecular Weight	290.97
Reaxy-Rn	28555026
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28555026&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
C2412122	Certificate of Analysis	Jun 17, 2025	B274990
C2412124	Certificate of Analysis	Jun 17, 2025	B274990
C2412126	Certificate of Analysis	Jun 17, 2025	B274990
C2412128	Certificate of Analysis	Jun 17, 2025	B274990
C2412130	Certificate of Analysis	Jun 17, 2025	B274990
C2412121	Certificate of Analysis	Dec 18, 2024	B274990
C2412127	Certificate of Analysis	Dec 18, 2024	B274990
C2412123	Certificate of Analysis	Dec 18, 2024	B274990
C2412125	Certificate of Analysis	Dec 18, 2024	B274990
C2412129	Certificate of Analysis	Dec 18, 2024	B274990

Chemical and Physical Properties

Solubility	Soluble in water to 20mM and in DMSO to 100mM
Sensitivity	Moisture sensitive
Molecular Weight	290.980 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	289.99 Da
Monoisotopic Mass	289.99 Da
Topological Polar Surface Area	116.000 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	196.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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