Skip to the beginning of the images gallery

BAY-0069 - 98%, high purity , CAS No.420826-65-9

COA

Grade & Purity:

≥98%

Cas Number: 420826-65-9
Molecular Weight: 466.28

In stock

Item Number

B646509

Grouped product items
SKU	Size	Availability	Price
B646509-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$100.90
B646509-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$160.90
B646509-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
B646509-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
B646509-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Lipid metabolism (1912) PPAR (155) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	BAY-0069 is a potent and selective PPARγ inverse agonist with an IC 50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ . BAY-0069 can be used to research cancer.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	BAY-0069 is a potent and selective PPARγ inverse agonist with an IC 50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ . BAY-0069 can be used to research cancer In Vitro BAY-0069 inhibits CYP2C8 with an IC 50 of 4.3 μM. BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: PPARγ-amplified cell line UM-UC-9 Concentration: 0.0001, 0.001, 0.01, 0.01 and 1 μM Incubation Time: 7 days Result: Inhibited PPARγ-amplified cell line UM-UC-9 with an IC 50 of 2.54 nM. In Vivo BAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CL b,hmic of 0.47 L/h/kg in human liver microsomes and CL b,rhep of 3.9 L/h/kg in rat liver hepatocytes . Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice . Route P.O. (100 mg/kg) I.P. S.C. AUC 0-tlast (mg/L·h) 0.074 0.26 0.045 C max (nM) 35 59 4.4 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:hPPARγ 6.3 nM (IC 50 ) mouse PPARγ 24 nM (IC 50 )

Names and Identifiers

Smiles	O=C(NC1=CC=C(OC(C2=CC=C(CC)C=C2)=N3)C3=C1)C4=CC([N+]([O-])=O)=CC=C4Br
Molecular Weight	466.28

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (214.46 mM; ultrasonic and warming and heat to 60°C)

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration