Basic Description

Synonyms	1094-61-7 \| beta-Nicotinamide mononucleotide \| nicotinamide mononucleotide \| NMN zwitterion \| beta-NMN \| Nicotinamide ribotide \| nicotinamide nucleotide \| NMN \| beta-nicotinamide D-ribonucleotide \| nicotinamide ribonucleotide \| nicotinamide D-ribonucleotide \| beta-Nicotinamide
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	Product of the NAMPT reaction and\xa0a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD + ). Ameliorates glucose intolerance by restoring NAD + levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitiv
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	A product of the eNAMPT reaction and a NAD+ intermediate β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Nucleosides, nucleotides, and analogues
  - Class Pyridine nucleotides
    - Subclass Nicotinamide nucleotides

Kingdom	Organic compounds
Superclass	Nucleosides, nucleotides, and analogues
Class	Pyridine nucleotides
Subclass	Nicotinamide nucleotides
Intermediate Tree Nodes	Not available
Direct Parent	Nicotinamide nucleotides
Alternative Parents	Pentose phosphates Glycosylamines Monosaccharide phosphates Nicotinamides Alkyl phosphates Pyridinium derivatives Vinylogous amides Tetrahydrofurans Heteroaromatic compounds Primary carboxylic acid amides Secondary alcohols 1,2-diols Azacyclic compounds Oxacyclic compounds Organic zwitterions Organic oxides Hydrocarbon derivatives Organonitrogen compounds Organopnictogen compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Nicotinamide-nucleotide - Pentose-5-phosphate - Pentose phosphate - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - Monosaccharide phosphate - Nicotinamide - Pyridine carboxylic acid or derivatives - Monosaccharide - Organic phosphoric acid derivative - Phosphoric acid ester - Alkyl phosphate - Pyridinium - Pyridine - Heteroaromatic compound - Vinylogous amide - Tetrahydrofuran - 1,2-diol - Carboxamide group - Secondary alcohol - Primary carboxylic acid amide - Azacycle - Oxacycle - Carboxylic acid derivative - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organic zwitterion - Alcohol - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as nicotinamide nucleotides. These are pyridine nucleotides, in which the pyridine base is nicotinamide or a derivative thereof.
External Descriptors	nicotinamide mononucleotide
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

LDHB Tchem L-lactate dehydrogenase B chain (463 Activities)

Discover Target: LDHB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDH1 Tchem Malate dehydrogenase cytoplasmic (119 Activities)

Discover Target: MDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase liver (1284 Activities)

Discover Target: GAPDH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

GLUD1 Glutamate dehydrogenase (27 Activities)

Discover Target: GLUD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

panE Ketopantoate reductase (28 Activities)

Discover Target: panE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
INCHI	InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
InChIKey	DAYLJWODMCOQEW-TURQNECASA-N
Smiles	C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N
Isomeric SMILES	C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)[O-])O)O)C(=O)N
WGK Germany	3
Molecular Weight	334.22
Beilstein	3570187
Reaxy-Rn	40276623
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=40276623&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Sensitivity	heat sensitive
Specific Rotation[α]	-24° (C=2,H2O)
Melt Point(°C)	166 °C
Molecular Weight	334.220 g/mol
XLogP3	-3.500
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	334.057 Da
Monoisotopic Mass	334.057 Da
Topological Polar Surface Area	166.000 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	455.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia. (2023) Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice. BEHAVIOURAL BRAIN RESEARCH, (114738).
2. Qi Shen, Shi-Jia Zhang, Bin-Hui Xu, Zhi-Yu Chen, Feng Peng, Neng Xiong, Ya-Ping Xue, Yu-Guo Zheng. (2023) Semirational engineering of Cytophaga hutchinsonii polyphosphate kinase for developing a cost-effective, robust, and efficient adenosine 5′-triphosphate regeneration system. APPLIED AND ENVIRONMENTAL MICROBIOLOGY,
3. Ruixue Duan, Yueping Li, Ruru Zhang, Xuelan Hu, Yi wang, Jianfeng Zeng, Mingyuan Gao. (2023) Reversing Acute Kidney Injury Through Coordinated Interplay of Anti-inflammation and Iron Supplementation. ADVANCED MATERIALS, (2301283).
4. Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao. (2023) A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples. NEW JOURNAL OF CHEMISTRY, 47 (16): (7862-7872).
5. Wu Yue, Yang Jingjuan, Xu Chengmei, Li Qiuqi, Ma Yage, Zhao Shenglan, Zhuang Jiachen, Shen Fei, Wang Qianqian, Feng Fengqin, Zhang Xi. (2022) Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans. Frontiers in Nutrition, 9
6. Zhongshi Huang, Ning Li, Shiqin Yu, Weiping Zhang, Tianmeng Zhang, Jingwen Zhou. (2022) Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide. ACS Synthetic Biology, 11 (9): (2979–2988).
7. Jinhui Hu, Ting Wang, Lin Zhou, Shaohua Wei. (2020) A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 209 (111955).
8. Zhang Weihong, Wang Dan, Wang Jie-Xin, Pu Yuan, Chen Jian-Feng. (2020) High-gravity-assisted emulsification for continuous preparation of waterborne polyurethane nanodispersion with high solids content. Frontiers of Chemical Science and Engineering, 14 (6): (1087-1099).
9. Guohan Sun, Shiqiao Wang, Jianfeng Zhou, Jianbin Pan, Yanli Tong, Qinghua Mei, Haiyun Zhai. (2020) Constructing a simple and sensitive electrochemical sensor for the determination of NMN based on p-m-ABSA film modified glassy carbon electrode. MICROCHEMICAL JOURNAL, 152 (104438).
10. Dengcheng Huang, Yu Zhou, Yuan Xiang, Meijie Shu, Hongxiang Chen, Bing Yang, Xinghua Liao. (2018) Polyurethane/doxorubicin nanoparticles based on electrostatic interactions as pH-sensitive drug delivery carriers. POLYMER INTERNATIONAL, 67 (9): (1186-1193).
11. Ma Le, Song Lina, Li Fang, Wang Heng, Liu Baohua. (2017) Preparation and properties of poly (propylene carbonate)-based waterborne polyurethane-acrylate composite emulsion. COLLOID AND POLYMER SCIENCE, 295 (12): (2299-2307).
12. Caideng Yuan, Mengyao Wang, Haitao Li, Zhongwei Wang. (2017) Preparation and properties of UV-curable waterborne polyurethane–acrylate emulsion. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (34): (45208).
13. Di Liu, Guo-Min Wu, Zhen-Wu Kong. (2016) Preparation and characterization of a polydimethylsiloxane-modified, epoxy-resin-based polyol dispersion and its crosslinked films. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (1):
14. Sude Ma, Guolin Song, Ningbo Feng. (2012) Preparation and characterization of self-emulsified waterborne nitrocellulose. CARBOHYDRATE POLYMERS, 89 (36).
15. Jinbang Han, Xiuzhong Zhu, Li Tian, Naishuo Yan, Haitao Zhang, Lei Wang. (2025) Bio-based waterborne polyurethanes from castor oil, sorbitan monooleate and sodium lignosulfonate with ultraviolet resistance, photothermal effect, corrosion protection and degradation properties. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 287 (138471).
16. Xin Chen, Jianyan Feng, Shuaishuai Han, Yang Bai, Peng Wang, Haoqiang Liu, Peng Zhang, Xiaomin Luo. (2024) Cellulose nanocrystal-modified bio-based aqueous polyurethane coating agent for kraft paper packaging. JOURNAL OF APPLIED POLYMER SCIENCE, 141 (32): (e55745).
17. Hanqi Yang, Jingdong Peng, Huanjun Peng, Hanlin Zeng, Jiayu Yu, Jiajia Wu, Xiang Wang. (2024) Dicationic imidazole ionic liquid stationary phase for preservative detection and its application under mixed mode of HILIC/RPLC/IEC. ANALYTICA CHIMICA ACTA, 1303 (342504).
18. Lewen Huang, Yibao Li, Zhong Zheng, Yun Bai, Thomas P. Russell, Changfei He. (2024) Flexible, transparent, and sustainable cellulose-based films for organic solar cell substrates. Materials Horizons, 11 (6): (1560-1566).
19. Jingting Zhang, Fu Chen. (2024) Integrated transcriptome and metabolome study reveal the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease. BIOMEDICINE & PHARMACOTHERAPY, 175 (116701).
20. Yuan Qie, Hailong Hu, Kuibao Yu, Chao Zhong, Songman Ju, Yanbing Liu, Tailiang Guo, Fushan Li. (2024) Ligand-Nondestructive Direct Photolithography Assisted by Semiconductor Polymer Cross-Linking for High-Resolution Quantum Dot Light-Emitting Diodes. NANO LETTERS, 24 (4): (1254-1260).
21. Yue-Yue Guo, Nan-Nan Liang, Xiao-Yi Zhang, Ya-Hui Ren, Wen-Zheng Wu, Zhi-Bing Liu, Yi-Zhang He, Yi-Hao Zhang, Yi-Chao Huang, Tao Zhang, De-Xiang Xu, Shen Xu. (2024) Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis. Redox Biology, 73 (103179).
22. Yingjie Du, Xiuyan Luo, Xiaohong Ye, Meijia Song, Yingjia Li, Shumao Yang, Caoxing Huang, Jiandong Cui. (2025) Molecular imprinted photoresponse hybrid biocatalyst for ultrasensitive glutamate detection. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 308 (142540).
23. Xinyi Lu, Pingping Jin, Qianyun Tang, Min Zhou, Hanjie Xu, Chen Su, Lei Wang, Feng Xu, Min Zhao, Yongxiang Yin, Jinqiu Zhang, Zhen Jia, Xinrui Peng, Jie Zhou, Lu Wang, Yan Chen, Min Wang, Min Yang, Daozhen Chen, Yu Chen. (2025) NAD+ Metabolism Reprogramming Drives SIRT1-Dependent Deacetylation Inducing PD-L1 Nuclear Localization in Cervical Cancer. Advanced Science, (2412109).
24. Shuangxi Zhang, Xinlin Wei, Rongbo Wang, Hejing Shen, Hehuan You, Langjun Cui, Yi Qiang, Peiqing Liu, Meixiang Zhang, Yuyan An. (2024) Nicotinamide mononucleotide confers broad-spectrum disease resistance in plants. Journal of Integrative Agriculture,
25. Zhanbo Sun, Lixian Liu, Hongyuan Liang, Lingyun Zhang. (2024) Nicotinamide mononucleotide induces autophagy and ferroptosis via AMPK/mTOR pathway in hepatocellular carcinoma. MOLECULAR CARCINOGENESIS,
26. Cao Yu-Ting, Lu Shuai-Wei, Zhou Yu-hang, Wei Jun. (2024) Novel organosilicon-modified polyisocyanate crosslinkers for curing of waterborne hydroxyl acrylic resin. Journal of Coatings Technology and Research, (1-9).
27. Yu Bai, Chenwei Dai, Nini Chen, Xiuhong Zhou, Hua Li, Qinghua Xu, Yong Xu. (2024) Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 75 (2): (91).
28. Zhilv Chen, Tao Wang, Chao Li, Mengxiang Fang, Wei Chen, Ximing Hu, Wei Zhang, li Zhang, Wenyang Fan, Shaojuan Zeng. (2025) Research on CO2 capture performance of DMEDA water-lean absorbents based on molecular dynamics. SEPARATION AND PURIFICATION TECHNOLOGY, 354 (128924).
29. Di Liu, Kang Yang, Liugen Xu, Xiran Shen, Lei Feng, Yangang Jiang, Amjad Ali, Jianwei Lu, Li Guo. (2024) Self-Assembly Study of Block Copolypeptoids in Response to pH and Temperature Stimulation. Polymers, 16 (8): (1082).
30. Chuanlong Wang, Qingyi Chen, Siyuan Chen, Lijuan Fan, Zhending Gan, Muyang Zhao, Lexuan Shi, Peng Bin, Guan Yang, Xihong Zhou, Wenkai Ren. (2024) Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation. MOLECULAR CELL,
31. Zhuolun Li, Yaqiao Wang, Haofan Lu, Yibo Sun, Xiangdong Wang, Shihong Chen. (2024) Stable nanoscale sea-island structure of biobased polyamide 56/poly (butylene adipate-co-terephthalate) blends compatibilized by interfacial hyperbranched structure: Toward biobased polymer blends with ultrahigh toughness. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 259 (129310).
32. Meiying Ge, Yonggui Li, Lixin Wu, Ren Liu, Jia-Tao Miao. (2024) Structural Design Strategy of a Biobased Allyl Compound with Dynamic Boronic Ester Bonds to Form Rigid-Soft Self-Healing Polymer Networks via Thiol–Ene “Click” Photopolymerization for Integrated Preparation of a Flexible Device. MACROMOLECULES, 57 (5): (2394-2402).
33. Zhaoyuan Zhang, Jiehu Liu, Meng Wang, Yang Li, Minglei Hou, Jiaren Cao, Jing Wu, Lingqia Su. (2025) Systematic modification of high nicotinamide mononucleotide production in Escherichia coli. JOURNAL OF BIOTECHNOLOGY,
34. Zhengyi Zhang, Baochen Cheng, Wenqian Du, Mengqi Zeng, Ke He, Tingyi Yin, Sen Shang, Tian Su, Dan Han, Xinyi Gan, Ziyang Wang, Meng Liu, Min Wang, Jiankang Liu, Yan Zheng. (2024) The Role of Nicotinamide Mononucleotide Supplementation in Psoriasis Treatment. Antioxidants, 13 (2): (186).

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β-Nicotinamide Mononucleotide (NMN) - 10mM in Water, high purity