Basic Description

Synonyms	BGP \| Glycerophosphate disodium salt hydrate
Specifications & Purity	UltraBio™, Moligand™, for cell culture, for plant cell culture, ≥99%(T)
Storage Temp	Room temperature
Shipped In	Normal
Grade	for cell culture, for plant cell culture, Moligand™, UltraBio™
Product Description	Glycerophosphoric acid disodium salt hydrate, also known as BGP, is a versatile compound with applications across various research domains, including cell biology, biochemical research, and metabolomics. Recognized as an endogenous metabolite and a serine-threonine phosphatase inhibitor, BGP is extensively utilized in chitosan hydrogel formulations for drug delivery research. It serves as a phosphate source for cell growth and recombinant protein production, offering advantages in media formulations by reducing precipitation at higher pH levels. Additionally, BGP finds applications in micro-arc oxidation electrolyte solutions, contributing to the creation of photocatalytic coatings. In cell biology, β-Glycerophosphate disodium salt plays a pivotal role as a phosphate group donor in matrix mineralization studies and accelerates calcification in vascular smooth muscle cells. It also promotes bone matrix mineralization when delivered to osteoblasts, providing a crucial source of phosphate ions. In the realm of biochemical research, BGP functions as a classical serine-threonine phosphatase inhibitor in kinase reaction buffers, offering broad-spectrum inhibition. Its role as an organic phosphate donor is particularly valuable in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. Moreover, BGP is utilized to buffer M17 media for Lactococcus culture in recombinant protein expression. The comprehensive utility of BGP spans multiple areas of research, making it an essential component in studies encompassing cell biology, biochemical research, and metabolomics. Application: β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression. Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Glycerophospholipids
    - Subclass Glycerophosphates

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Glycerophospholipids
Subclass	Glycerophosphates
Intermediate Tree Nodes	Not available
Direct Parent	Glycerophosphates
Alternative Parents	Alkyl phosphates Primary alcohols Organic sodium salts Organic oxides Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	Sn-glycerol-2-phosphate - Alkyl phosphate - Phosphoric acid ester - Organic phosphoric acid derivative - Organic alkali metal salt - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic sodium salt - Organic salt - Primary alcohol - Organooxygen compound - Alcohol - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as glycerophosphates. These are compounds containing a glycerol linked to a phosphate group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	disodium;1,3-dihydroxypropan-2-yl phosphate;hydrate
INCHI	InChI=1S/C3H9O6P.2Na.H2O/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;;1H2/q;2*+1;/p-2
InChIKey	ROPZSVKNEIIIDE-UHFFFAOYSA-L
Smiles	C(C(CO)OP(=O)([O-])[O-])O.O.[Na+].[Na+]
Isomeric SMILES	C(C(CO)OP(=O)([O-])[O-])O.O.[Na+].[Na+]
Molecular Weight	216.04 (anhydrous basis)
Reaxy-Rn	29800820
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29800820&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
B2520427	Certificate of Analysis	Feb 08, 2025	G755749
B2520428	Certificate of Analysis	Feb 08, 2025	G755749
B2520429	Certificate of Analysis	Feb 08, 2025	G755749
D2510017	Certificate of Analysis	Feb 08, 2025	G755749
B2520424	Certificate of Analysis	Feb 08, 2025	G755749
B2520425	Certificate of Analysis	Feb 08, 2025	G755749
B2520426	Certificate of Analysis	Feb 08, 2025	G755749

Chemical and Physical Properties

Solubility	water: soluble
Melt Point(°C)	102～104 ℃
Molecular Weight	234.050 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	233.988 Da
Monoisotopic Mass	233.988 Da
Topological Polar Surface Area	114.000 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	113.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	4

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Di Hu, Dakun Long, Tian Xia, Yunhao Wang, Shicheng Zhang, Jianjie Wang, Xiaowen Shi, Yanfeng Wang. (2024) Accelerated healing of intractable biofilm-infected diabetic wounds by trypsin-loaded quaternized chitosan hydrogels that disrupt extracellular polymeric substances and eradicate bacteria. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (134677).
2. Chenyang Li, Shuai Wang, Chenghui Liao, Ying Li, Yunfeng Zhou, Haiqiang Wu, Wei Xiong. (2024) An In Situ Sustained-Release Chitosan Hydrogel to Attenuate Renal Fibrosis by Retaining Klotho Expression. Biomaterials Research, 28 (2024 Oct;28).
3. Fanyi Guo, Jianfeng Li, Ziyu Chen, Tianxiao Wang, Ruyu Wang, Tianyao Wang, Yifeng Bian, Yifei Du, Hua Yuan, Yongchu Pan, Jianliang Jin, Huijun Jiang, Feng Han, Jiandong Jiang, Fan Wu, Yuli Wang. (2024) An Injectable Black Phosphorus Hydrogel for Rapid Tooth Extraction Socket Healing. ACS Applied Materials & Interfaces, 16 (20): (25799-25812).
4. Dongxu Gao, Yuan Zhao, Junfeng Liu, Runxuan Chu, Junji Wang, Wei Bian, Xuejie Liu, Weigen Lu, Jun He. (2025) Bupivacaine multivesicular liposomes/meloxicam nanocrystals in a thermosensitive gel adapted to the “microenvironment” for long-term analgesia. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, (114630).
5. Heyi Su, Fan Yang, Keyi Lu, Jiaxian Ma, Guangming Huo, Shengjie Li, Jianmei Li. (2024) Carnosic acid ameliorates postinflammatory hyperpigmentation by inhibiting inflammatory reaction and melanin deposition. BIOMEDICINE & PHARMACOTHERAPY, 180 (117522).
6. Xueyan Hou, Yalin Guan, Yanan Lu, Yuxin Wang, Suyue Xu, Huiqing Zhu, Jingya Zhao, Liu Xiao, Sisi He, Yongli Shi. (2025) Chitosan-based thermosensitive injectable hydrogel with hemostatic and antibacterial activity for preventing breast cancer postoperative recurrence and metastasis via chemo-photothermal therapy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 290 (138930).
7. Zhou Hao, Wang Wei, Cai Zedong, Jia Zhou-Yan, Li Yu-Yao, He Wei, Li Chen, Zhang Bang-Le. (2024) Injectable hybrid hydrogels enable enhanced combination chemotherapy and roused anti-tumor immunity in the synergistic treatment of pancreatic ductal adenocarcinoma. JOURNAL OF NANOBIOTECHNOLOGY, 22 (1): (1-21).
8. Shasha Zhou, Jibing He, Quan Liu, Ting Chen, Xiangheng Guan, Haihan Gao, Jia Jiang, Jiaxing Wang, Xiaochun Peng, Jinglei Wu. (2024) Injectable Hydrogel of Chitosan-Octyl Itaconate Conjugate Modulates Inflammatory Response. ACS Biomaterials Science & Engineering, 10 (8): (4823-4838).
9. Lin Wei, Hou Lianglei, Tang Jialyu, Huang Anwu, Jia Zhuyin. (2024) Mir-195-5p targets Smad7 regulation of the Wnt/β-catenin pathway to promote osteogenic differentiation of vascular smooth muscle cells. BMC Cardiovascular Disorders, 24 (1): (1-11).
10. Danmeng Bai, Haoxin Cheng, Junmin Mei, Guangqi Tian, Qingqing Wang, Simin Yu, Jie Gao, Yanhua Zhong, Hongbo Xin, Xiaolei Wang. (2024) Rapid formed temperature-sensitive hydrogel for the multi-effective wound healing of deep second-degree burn with shikonin based scar prevention. Biomaterials Advances, 160 (213851).
11. Xueting Wang, Hui Zhang, Ling Hu, Jin He, Qifeng Jiang, Lingfei Ren, Ke Yu, Mengdie Fu, Zhikun Li, Zhixu He, Junhao Zhu, Ying Wang, Zhiwei Jiang, Guoli Yang. (2024) The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation. BONE, 187 (117172).
12. Jinjin Tong, Zezheng Liu, Kexuan Zhou, Kaiming Wang, Shijiao Guo, Hua Zhang. (2025) Thermosensitive bovine lactoferricin-loaded chitosan hydrogels for sustained antibacterial release: An alternative to antibiotics for treating bovine mastitis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 303 (140673).
13. Ye Yan, Zhong Wenzhen, Luo Ruifeng, Wen Hongzhi, Ma Ziyang, Qi Shanshan, Han Xiaoqin, Nie Wenbiao, Chang Degui, Xu Runchun, Ye Naijing, Gao Fei, Zhang Peihai. (2024) Thermosensitive hydrogel with emodin-loaded triple-targeted nanoparticles for a rectal drug delivery system in the treatment of chronic non-bacterial prostatitis. JOURNAL OF NANOBIOTECHNOLOGY, 22 (1): (1-19).

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SKU	Size	Availability	Price
G755749-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$28.90
G755749-50g	50g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$112.90
G755749-100g	100g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$179.90

β-Glycerophosphate disodium salt hydrate（BGP） - UltraBio™, Moligand™, for cell culture, for plant cell culture, ≥99%(T), high purity , CAS No.154804-51-0