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Azvudine , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.1011529-10-4, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

COA

Grade & Purity:

≥98%

Cas Number: 1011529-10-4
Molecular Weight: 286.22
PubChem CID: 24769759

In stock

Item Number

A648672

Grouped product items
SKU	Size	Availability	Price
A648672-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$129.90
A648672-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$219.90
A648672-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$429.90
A648672-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$649.90
A648672-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$999.90

View related series

Anti-infection (2803) HBV (114) HCV (160) Reverse Transcriptase (71) Virus (1811)

Basic Description

Synonyms	RO-0622 \| F86375 \| 1011529-10-4 \| 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine \| 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one \| Azvudine \| FNCRO-0622 \| A848947 \| DTXSID901027757 \| AKOS040741284 \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV , HBV and HCV . Azvudine exerts highly potent inhibition on HIV-1 (EC 50 s ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 s ranging from 0.018
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Product Description	Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazines
    - Subclass Pyrimidines and pyrimidine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazines
Subclass	Pyrimidines and pyrimidine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Pyrimidones
Alternative Parents	Aminopyrimidines and derivatives Primary aromatic amines Hydropyrimidines Imidolactams Oxolanes Heteroaromatic compounds Secondary alcohols Azo compounds Azo imides Fluorohydrins Azacyclic compounds Oxacyclic compounds Hydrocarbon derivatives Organic zwitterions Organofluorides Organopnictogen compounds Primary alcohols Alkyl fluorides Organic salts Organic oxides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Aminopyrimidine - Pyrimidone - Hydropyrimidine - Imidolactam - Primary aromatic amine - Heteroaromatic compound - Oxolane - Azo compound - Azo imide - Fluorohydrin - Halohydrin - Secondary alcohol - Oxacycle - Azacycle - Organic zwitterion - Primary amine - Primary alcohol - Alkyl fluoride - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Alkyl halide - Organic salt - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as pyrimidones. These are compounds that contain a pyrimidine ring, which bears a ketone. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	-0.8

Associated Targets(Human)

Homo sapiens (32628 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MT2 (2907 Activities)

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MT4 (17854 Activities)

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HEK293 (82097 Activities)

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Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis B virus (7925 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human immunodeficiency virus 1 (70413 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis C virus (23859 Activities)

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
INCHI	InChI=1S/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6-,7+,9+/m0/s1
InChIKey	KTOLOIKYVCHRJW-XZMZPDFPSA-N
Smiles	C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F
Isomeric SMILES	C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)F
Alternate CAS	1011529-10-4
PubChem CID	24769759
MeSH Entry Terms	2'-deoxy-2'-beta-fluoro-4'-azidocytidine;4'-azido-2'-deoxy-2'-fluorocytidine;4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-((imino-l,5-azanylidene)amino)tetrahydrofuran-2-yl)pyrimidin-2-one;4-amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(
Molecular Weight	286.22

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
J2425615	Certificate of Analysis	Aug 29, 2024	A648672
J2425771	Certificate of Analysis	Aug 29, 2024	A648672
J2425772	Certificate of Analysis	Aug 29, 2024	A648672
J2425775	Certificate of Analysis	Aug 29, 2024	A648672
J2425364	Certificate of Analysis	Aug 29, 2024	A648672
J2425366	Certificate of Analysis	Aug 29, 2024	A648672
J2425368	Certificate of Analysis	Aug 29, 2024	A648672
J2425362	Certificate of Analysis	Aug 29, 2024	A648672
J2425361	Certificate of Analysis	Aug 29, 2024	A648672
J2425363	Certificate of Analysis	Aug 29, 2024	A648672

Chemical and Physical Properties

Solubility	DMSO : 125 mg/mL (436.73 mM; Need ultrasonic)
Molecular Weight	286.220 g/mol
XLogP3	-0.800
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	286.083 Da
Monoisotopic Mass	286.083 Da
Topological Polar Surface Area	123.000 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	533.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	1
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

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Azvudine , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.1011529-10-4, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Alternative Products

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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