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AZD5904 , CAS No.A607876, Inhibitor of myeloperoxidase

COA COA
In stock
Item Number
A607876
Grouped product items
SKU Size
Availability
 Price Qty
A607876-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
A607876-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$149.90
A607876-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
A607876-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$549.90
A607876-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$771.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Drug targets (3) Enzyme inhibitor (15) Ferroptosis (356) Glucose Metabolism (1943) Glutathione Peroxidase (23) Inhibitors&Agonists (15) Metabolize (5) myeloperoxidase Inhibitor (7)

Basic Description

Synonyms 2-sulfanylidene-3-[(2R)-tetrahydro-2-furanylmethyl]-1,2,3,7-tetrahydro-6H-purin-6-one | AZD 5904 [WHO-DD] | 3-[[(2~{R})-oxolan-2-yl]methyl]-2-sulfanylidene-9~{H}-purin-6-one | 62A9CG81VN | Q27074766 | MS-23562 | 1,2,3,9-Tetrahydro-3-(((2R)-tetrahydro-2-fu
Specifications & Purity Moligand™, ≥98%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of myeloperoxidase
Product Description

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Imidazopyrimidines
Subclass Purines and purine derivatives
Intermediate Tree Nodes Not available
Direct Parent Thioxanthines
Alternative Parents 6-oxopurines  2-Thiopyrimidines  Pyrimidones  Pyrimidinethiones  Vinylogous amides  Heteroaromatic compounds  Imidazoles  Oxolanes  Lactams  Thioureas  Azacyclic compounds  Oxacyclic compounds  Dialkyl ethers  Hydrocarbon derivatives  Organic oxides  Organonitrogen compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Thioxanthine - 6-oxopurine - Purinone - 2-thiopyrimidine - Thiopyrimidine - Pyrimidinethione - Pyrimidone - Pyrimidine - Azole - Imidazole - Oxolane - Heteroaromatic compound - Vinylogous amide - Lactam - Thiourea - Oxacycle - Ether - Dialkyl ether - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as thioxanthines. These are organic polycyclic compounds containing a thioxanthine moiety, which is an aromatic bicyclic structure derived from xanthine by replacing a carbonyl group with a thiocarbonyl group.
External Descriptors Not available

Associated Targets(Human)

MPO Tchem Myeloperoxidase (5 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TPO Tclin Thyroid peroxidase (64 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MPO Tchem Myeloperoxidase (1002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 3-[[(2R)-oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one
INCHI InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1
InChIKey RSPDBEVKURKEII-ZCFIWIBFSA-N
Smiles C1CC(OC1)CN2C3=C(C(=O)NC2=S)NC=N3
Isomeric SMILES C1C[C@@H](OC1)CN2C3=C(C(=O)NC2=S)NC=N3
Alternate CAS 618913-30-7
PubChem CID 10264211
Molecular Weight 252.29

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility DMSO: 2 mg/mL, clear
Molecular Weight 252.300 g/mol
XLogP3 0.500
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 2
Exact Mass 252.068 Da
Monoisotopic Mass 252.068 Da
Topological Polar Surface Area 102.000 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 351.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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