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AX-024 HCl - 10mM in DMSO, high purity , CAS No.1704801-24-0
Basic Description
| Synonyms |
AX-024 hydrochloride | 1-[[4-(4-fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]-,hydrochloride (1:1) |
| Specifications & Purity |
10mM in DMSO |
| Biochemical and Physiological Mechanisms |
AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A. |
| Storage Temp |
Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
Information AX-024 HCl AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6 , TNF-α , IFN-γ , IL-10 and IL-17A . |
Product Properties
| ALogP |
4.579 |
| hba_count |
2 |
| Rotatable Bond |
4 |
Names and Identifiers
| IUPAC Name |
1-[[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine;hydrochloride |
| INCHI |
InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H |
| InChIKey |
DGBCIMPGYRVTPD-UHFFFAOYSA-N |
| Smiles |
COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4.Cl |
| Alternate CAS |
1370544-73-2 |
| Molecular Weight |
375.86 |
| Reaxy-Rn |
30387316 |
| Reaxys-RN_link_address |
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30387316&ln= |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
| DMSO(mg / mL) Max Solubility |
75 |
| DMSO(mM) Max Solubility |
199.542382802107 |
| Water(mg / mL) Max Solubility |
4 |
| Water(mM) Max Solubility |
10.6422604161124 |
| Molecular Weight |
375.900 g/mol |
| XLogP3 |
|
| Hydrogen Bond Donor Count |
1 |
| Hydrogen Bond Acceptor Count |
4 |
| Rotatable Bond Count |
4 |
| Exact Mass |
375.14 Da |
| Monoisotopic Mass |
375.14 Da |
| Topological Polar Surface Area |
21.700 Ų |
| Heavy Atom Count |
26 |
| Formal Charge |
0 |
| Complexity |
480.000 |
| Isotope Atom Count |
0 |
| Defined Atom Stereocenter Count |
0 |
| Undefined Atom Stereocenter Count |
0 |
| Defined Bond Stereocenter Count |
0 |
| Undefined Bond Stereocenter Count |
0 |
| The total count of all stereochemical bonds |
0 |
| Covalently-Bonded Unit Count |
2 |
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