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AWD 131-138 - 98%, high purity , CAS No.188116-07-6

    Grade & Purity:
  • ≥98%
In stock
Item Number
A413268
Grouped product items
SKU Size
Availability
Price Qty
A413268-5mg
5mg
3
$86.90
A413268-25mg
25mg
2
$391.90
A413268-100mg
100mg
2
$815.90

GABA Receptor Activators

Basic Description

Synonyms 1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one | ADD-233089 | imepitoinum | AC-36287 | Imepitoin | imepitoine | BCP08396 | HMS3886O19 | 2H-Imidazol-2-one, 1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)- | IMEPITOIN [EMA EPAR VETERINA
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. AWD 131-138 (Imepitoin) is an antiepileptic and antianxietic drug, AWD 131-138 can sti
Storage Temp Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Information

AWD 131-138 AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. AWD 131-138 (Imepitoin) is an antiepileptic and antianxietic drug, AWD 131-138 can stimulate different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Halobenzenes
Intermediate Tree Nodes Not available
Direct Parent Chlorobenzenes
Alternative Parents Morpholines  Aryl chlorides  Imidazolines  Propargyl-type 1,3-dipolar organic compounds  Oxacyclic compounds  Dialkyl ethers  Carboximidamides  Carboxamidines  Azacyclic compounds  Organochlorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  Amines  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Chlorobenzene - Aryl chloride - Aryl halide - Morpholine - Oxazinane - 3-imidazoline - Amidine - Carboxylic acid amidine - Dialkyl ether - Ether - Oxacycle - Azacycle - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxygen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Carbonyl group - Amine - Organic oxide - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as chlorobenzenes. These are compounds containing one or more chlorine atoms attached to a benzene moiety.
External Descriptors Not available

Product Properties

ALogP 1.44
hba_count 3
Rotatable Bond 2

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cynomolgus monkey (4946 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gabrp GABA-A receptor; anion channel (5731 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504762407
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504762407
IUPAC Name 3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one
INCHI InChI=1S/C13H14ClN3O2/c14-10-1-3-11(4-2-10)17-9-12(15-13(17)18)16-5-7-19-8-6-16/h1-4H,5-9H2
InChIKey IQHYCZKIFIHTAI-UHFFFAOYSA-N
Smiles C1COCCN1C2=NC(=O)N(C2)C3=CC=C(C=C3)Cl
Isomeric SMILES C1COCCN1C2=NC(=O)N(C2)C3=CC=C(C=C3)Cl
Molecular Weight 279.72
Reaxy-Rn 8917426
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8917426&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
G2228262 Certificate of Analysis May 09, 2025 A413268
G2228310 Certificate of Analysis May 09, 2025 A413268
G2228311 Certificate of Analysis May 09, 2025 A413268

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 30 mg/mL (107.25 mM); Ethanol: 2 mg/mL (7.15 mM); Water: Insoluble;
Sensitivity light sensitive
DMSO(mg / mL) Max Solubility 30
DMSO(mM) Max Solubility 107.250107250107
Water(mg / mL) Max Solubility <1
Molecular Weight 279.720 g/mol
XLogP3 1.200
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 2
Exact Mass 279.077 Da
Monoisotopic Mass 279.077 Da
Topological Polar Surface Area 45.100 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 374.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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