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astressin 2B, Antagonist of CRF 1 receptor;Antagonist of CRF 2 receptor, CAS No.rp173499, Antagonist of CRF 1 receptor;Antagonist of CRF 2 receptor

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rp173499
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rp173499-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
rp173499-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,334.90

Basic Description

Product Name astressin 2B, Antagonist of CRF 1 receptor;Antagonist of CRF 2 receptor, CAS No.rp173499
Synonyms Astressin2-B | astressin₂-B | cyclo(31-34)[DPhe(11),His(12),C(alpha)MeLeu(13,39),Nle(17),Glu(31),Lys(34)]Ac-sauvagine(8-40) | peptide 20
Grade Moligand™
Specifications & Purity Moligand™
Action Type ANTAGONIST
Mechanism of action Antagonist of CRF 1 receptor;Antagonist of CRF 2 receptor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic Polymers
Class Polypeptides
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Polypeptides
Alternative Parents Cyclic peptides  Hexacarboxylic acids and derivatives  Phenylalanine and derivatives  Arginine and derivatives  Histidine and derivatives  Glutamic acid and derivatives  Glutamine and derivatives  Aspartic acid and derivatives  Isoleucine and derivatives  Leucine and derivatives  N-acyl-alpha amino acids and derivatives  Macrolactams  Serine and derivatives  Alpha amino acid amides  Alanine and derivatives  Amphetamines and derivatives  Imidazolyl carboxylic acids and derivatives  N-acyl amines  Heteroaromatic compounds  Acetamides  Guanidines  Primary carboxylic acid amides  Secondary carboxylic acid amides  Amino acids  Lactams  Azacyclic compounds  Carboxylic acids  Carboximidamides  Carbonyl compounds  Hydrocarbon derivatives  Imines  Monoalkylamines  Organic oxides  Organopnictogen compounds  Primary alcohols  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Polypeptide - Cyclic alpha peptide - Hexacarboxylic acid or derivatives - Phenylalanine or derivatives - Arginine or derivatives - Histidine or derivatives - Glutamine or derivatives - Glutamic acid or derivatives - Leucine or derivatives - Isoleucine or derivatives - Aspartic acid or derivatives - Macrolactam - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Serine or derivatives - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - Imidazolyl carboxylic acid derivative - Fatty amide - Fatty acyl - Benzenoid - Monocyclic benzene moiety - N-acyl-amine - Heteroaromatic compound - Acetamide - Imidazole - Azole - Guanidine - Amino acid - Lactam - Carboxamide group - Secondary carboxylic acid amide - Amino acid or derivatives - Primary carboxylic acid amide - Organoheterocyclic compound - Carboximidamide - Azacycle - Carboxylic acid derivative - Carboxylic acid - Hydrocarbon derivative - Organic oxygen compound - Organopnictogen compound - Imine - Organic oxide - Carbonyl group - Primary aliphatic amine - Alcohol - Organonitrogen compound - Organooxygen compound - Amine - Primary alcohol - Primary amine - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
External Descriptors Not available

Associated Targets(Human)

CRHR2 Tchem Corticotropin-releasing factor receptor 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CRHR1 Tclin Corticotropin-releasing factor receptor 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

CAS rp173499

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Genetic information

Alternate Names Astressin2-B | astressin₂-B | cyclo(31-34)[DPhe(11),His(12),C(alpha)MeLeu(13,39),Nle(17),Glu(31),Lys(34)]Ac-sauvagine(8-40) | peptide 20
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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