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Astaxanthin - 10mM in DMSO, high purity , CAS No.472-61-7, Antioxidant, anti-inflammatory and antiapoptotic activities

    Grade & Purity:
  • 10mM in DMSO
In stock
Item Number
A424114
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Price Qty
A424114-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$67.90

Basic Description

Synonyms Astaxanthin | 472-61-7 | Ovoester | all-trans-Astaxanthin | AstaREAL | 3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione | Astaxanthine | BioAstin | (3S,3'S)-Astaxanthin | trans-Astaxanthin | Astaxanthin, (3S,3'S)- | (3S,3'S)-all-trans-Astaxanthin | 8XPW32PR7I | 3,3'-Dihydroxy-beta-car
Specifications & Purity 10mM in DMSO
Biochemical and Physiological Mechanisms Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory
Storage Temp Protected from light,Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action Antioxidant, anti-inflammatory and antiapoptotic activities
Product Description

Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.
Astaxanthin is a potent carotenoid antioxidant found in marine algae, red yeast and many other plant and animal sources. Animal studies indicate that it reduces blood glucose and ameliorates several parameters of the diabetic metabolic syndrome. It improves blood flow and vascular tone in models of hypertension. In vitro studies indicate that it upregulates connexin 43 and thus, may be chemopreventive against cancer.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Prenol lipids
Subclass Tetraterpenoids
Intermediate Tree Nodes Carotenoids
Direct Parent Xanthophylls
Alternative Parents Cyclohexenones  Secondary alcohols  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aliphatic homomonocyclic compounds
Substituents Xanthophyll - Cyclohexenone - Cyclic ketone - Secondary alcohol - Ketone - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as xanthophylls. These are carotenoids containing an oxygenated carotene backbone. Carotenes are characterized by the presence of two end-groups (mostly cyclohexene rings, but also cyclopentene rings or acyclic groups) linked by a long branched alkyl chain. Carotenes belonging form a subgroup of the carotenoids family. Xanthophylls arise by oxygenation of the carotene backbone.
External Descriptors C40 isoprenoids (tetraterpenes)

Product Properties

ALogP 10.3

Associated Targets(Human)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (6S)-6-hydroxy-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethyl-3-oxocyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,4,4-trimethylcyclohex-2-en-1-one
INCHI InChI=1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1
InChIKey MQZIGYBFDRPAKN-UWFIBFSHSA-N
Smiles CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C
Isomeric SMILES CC1=C(C(C[C@@H](C1=O)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C(=O)[C@H](CC2(C)C)O)C)\C)\C)/C)/C
WGK Germany 3
Alternate CAS 7542-45-2
Molecular Weight 596.84
Reaxy-Rn 11489489
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11489489&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity light and air sensitive
Melt Point(°C) 215-216°C
Molecular Weight 596.800 g/mol
XLogP3 10.300
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 10
Exact Mass 596.387 Da
Monoisotopic Mass 596.387 Da
Topological Polar Surface Area 74.600 Ų
Heavy Atom Count 44
Formal Charge 0
Complexity 1340.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 9
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 9
Covalently-Bonded Unit Count 1

Citations of This Product

1. Lei Diao, Wenjie Liu, Yawei Xu, Bin Zhang, Lingnan Meng, Rui Yin, Huijie Chen.  (2024)  New insights into micro-algal astaxanthin's effect on deoxynivalenol-induced spleen lymphocytes pyroptosis in Cyprinus carpio: Involving mitophagy and mtROS-NF-κB-dependent NLRP3 inflammasome.  FISH & SHELLFISH IMMUNOLOGY,  144  (109259). 
2. Pengjing Zhang, Yuanda Sun, Yitong Hou, Haitao Wang, Mingqian Tan.  (2024)  Fabrication of novel W/O/W emulsion gels using beeswax stabilized W/O: Preparation, characterization and co-delivery of phycocyanin and astaxanthin.  Food Bioscience,  57  (103536). 
3. Zi-Xu Zhang, Lu-Wei Xu, Ying-Shuang Xu, Jin Li, Wang Ma, Xiao-Man Sun, He Huang.  (2024)  Integration of genetic engineering and multi-factor fermentation optimization for co-production of carotenoid and DHA in Schizochytrium sp.  BIORESOURCE TECHNOLOGY,  394  (130250). 
4. Lei Diao, Meiqi Ding, Hongzhen Sun, Yawei Xu, Rui Yin, Huijie Chen.  (2023)  Micro-algal astaxanthin ameliorates polystyrene microplastics-triggered necroptosis and inflammation by mediating mitochondrial Ca2+ homeostasis in carp’s head kidney lymphocytes (Cyprinus carpio L.).  FISH & SHELLFISH IMMUNOLOGY,  143  (109205). 
5. Swagata Dutta, S.P. Jeevan Kumar, Rintu Banerjee.  (2023)  A comprehensive review on astaxanthin sources, structure, biochemistry and applications in the cosmetic industry.  Algal Research-Biomass Biofuels and Bioproducts,  74  (103168). 
6. Dong Su, Junkui Miao, Xiaofang Liu, Xixi Wang, Yuan Yu, Kailiang Leng, Yueqin Yu.  (2023)  Separation and concentration of phospholipids and glycerides from ethanol extraction of krill by hydration and solvent partitioning.  SEPARATION AND PURIFICATION TECHNOLOGY,  317  (123900). 
7. Yingyuan Zhao, Zhaoxuan Wang, Shuxian Liu, Shiying Xie, Yinchun Xie, Ruifang Li, Hiroaki Oda.  (2023)  Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension.  Biomolecules,  13  (3): (496). 
8. Xin-Nan Teng, Shu-Chang Wang, Liaqat Zeb, Yue-Sheng Dong, Zhi-Long Xiu.  (2023)  Two-Step Enzymolysis of Antarctic Krill for Simultaneous Preparation of Value-Added Oil and Enzymolysate.  Marine Drugs,  21  (1): (47). 
9. Yu Fei, Chen Jiaxin, Wei Zizhan, Zhu Pingchuan, Qing Qing, Li Bangda, Chen Huimin, Lin Weiying, Yang Hua, Qi Zhongquan, Hong Xuehui, Chen Xiao Dong.  (2022)  Preparation of carrier-free astaxanthin nanoparticles with improved antioxidant capacity.  Frontiers in Nutrition,   
10. Sun Xixi, Yuan Yujie, Chen Qitong, Nie Shiqi, Guo Jiaxuan, Ou Zutian, Huang Min, Deng Zixin, Liu Tiangang, Ma Tian.  (2022)  Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases.  Nature Communications,  13  (1): (1-12). 
11. Zhi-Ang Liu, Ya-Nan Zuo, Yinghui Xia, Jing Sun, Shuyun Zhu.  (2022)  Enhanced detection of ascorbic acid with cascaded fluorescence recovery of a dual-nanoquencher system.  Analytical Methods,  14  (37): (3632-3637). 
12. Shi Zhihui, He Xiaoxian, Zhang Hailiang, Guo Xuena, Cheng Yanfei, Liu Xuelian, Wang Zhaoyue, He Xiuping.  (2022)  Whole Genome Sequencing and RNA-seq-Driven Discovery of New Targets That Affect Carotenoid Synthesis in Phaffia rhodozyma.  Frontiers in Microbiology,  13   
13. Hang-Zhi Zhu, Shan Jiang, Jun-Jie Wu, Xue-Rong Zhou, Peng-Yang Liu, Feng-Hong Huang, Xia Wan.  (2022)  Production of High Levels of 3S,3′S-Astaxanthin in Yarrowia lipolytica via Iterative Metabolic Engineering.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (8): (2673–2683). 
14. Lijun Ding, Jie Yang, Kangrui Yin, Hao Cheng, Jing Li, Changhu Xue.  (2022)  The spatial arrangement of astaxanthin in bilayers greatly influenced the structural stability of DPPC liposomes.  COLLOIDS AND SURFACES B-BIOINTERFACES,  212  (112383). 
15. Shujie Wang, Kefei Chen, Guoqin Liu.  (2022)  Monoglyceride oleogels for lipophilic bioactive delivery – Influence of self-assembled structures on stability and in vitro bioaccessibility of astaxanthin.  FOOD CHEMISTRY,  375  (131880). 
16. Zhipeng Qi, Xianyu Fan, Chunyi Zhu, Dongsheng Chang, Jianjun Pei, Linguo Zhao.  (2021)  Overexpression and Characterization of a Novel Plant Carotenoid Cleavage Dioxygenase 1 from Morus notabilis.  CHEMISTRY & BIODIVERSITY,  19  (2): (e202100735). 
17. Ru Song, Yu Qi, Zhe Jia, Xinyan Liu, Rongbian Wei.  (2020)  Astaxanthin-loaded zein/calcium alginate composite microparticles: Characterization, molecular interaction and release kinetics in fatty food simulant system.  LWT-FOOD SCIENCE AND TECHNOLOGY,  134  (110146). 
18. Jianfeng Mei, Xiaoyun Zhao, Yu Yi, Yanlu Zhang, Xudong Wang, Guoqing Ying.  (2020)  Preparation of astaxanthin by lipase-catalyzed hydrolysis from its esters in a slug-flow microchannel reactor.  PROCESS BIOCHEMISTRY,  98  (241). 
19. Xujian Qiu, Yumeng Wu, Shengjun Chen, Lechang Sun, Guangming Liu, Hong Lin.  (2020)  Oxidative Stability and Browning Development of Semi-dried Shrimp (Acetes chinensis) with Different Salt Contents and Packaging Methods Stored at Refrigerated Temperature.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,     
20. Yunchang Fan, Zeyu Niu, Chen Xu, Lei Yang, Feiyang Chen, He Zhang.  (2019)  Biocompatible protic ionic liquids-based microwave-assisted liquid-solid extraction of astaxanthin from Haematococcus pluvialis.  INDUSTRIAL CROPS AND PRODUCTS,  141  (111809). 
21. Yanbin Wang, Yao Liu, Yuchen Li, Binbing Liu, Pei Wu, Shancai Xu, Huaizhang Shi.  (2019)  Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.  ACTA HISTOCHEMICA,  121  (56). 
22. Zhi-Wei Liu, Xin-An Zeng, Jun-Hu Cheng, De-Bao Liu, Rana Muhammad Aadil.  (2018)  The efficiency and comparison of novel techniques for cell wall disruption in astaxanthin extraction from Haematococcus pluvialis.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  53  (9): (2212-2219). 
23. Dan Xie, Hongyan Mu, Tianpei Tang, Xiaosan Wang, Wei Wei, Jun Jin, Xingguo Wang, Qingzhe Jin.  (2018)  Production of three types of krill oils from krill meal by a three-step solvent extraction procedure.  FOOD CHEMISTRY,  248  (279). 
24. Tian Ma, Yuanjie Zhou, Xiaowei Li, Fayin Zhu, Yongbo Cheng, Yi Liu, Zixin Deng, Tiangang Liu.  (2015)  Genome mining of astaxanthin biosynthetic genes from Sphingomonas sp. ATCC 55669 for heterologous overproduction in Escherichia coli.  Biotechnology Journal,  11  (2): (228-237). 
25. Jingwen Han, Jiamin Ye, Jiacheng Shi, Yueyue Fan, Xue Yuan, Ruiyan Li, Gaoli Niu, Muhammad Abubakar, Yong Kang, Xiaoyuan Ji.  (2024)  A Programmable Oral Nanomotor Microcapsule for the Treatment of Inflammatory Bowel Disease.  ADVANCED FUNCTIONAL MATERIALS,    (2413261). 
26. Shujie Cheng, Shimin Wu.  (2024)  A shelf life prediction method for butter based on the effects of β-carotene on colour and oxidative stability.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,  77  (3): (961-972). 
27. Xiuping Lin, Chang-sheng Shao, Shereen M. Elsherbiny, Qing Huang.  (2024)  Astaxanthin attenuates UV-irradiation aging process via activating JNK-1/DAF-16 in Caenorhabditis elegans.  PHOTOCHEMISTRY AND PHOTOBIOLOGY,     
28. Yahui Wu, Mona Alrasheed Bashir, Changsheng Shao, Han Wang, Jianxia Zhu, Qing Huang.  (2024)  Astaxanthin targets IL-6 and alleviates the LPS-induced adverse inflammatory response of macrophages.  Food & Function,     
29. Shujie Cheng, Shimin Wu, Jianqiang Lan.  (2024)  Beta-carotene and astaxanthin inhibit the formation of polycyclic aromatic hydrocarbons and oxygenated polycyclic aromatic hydrocarbons in butter during heat treatment.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,     
30. Shujie Wang, Yuyue Qin, Yaping Liu, Guoqin Liu, Guiguang Cheng, Thanapop Soteyome.  (2024)  Controlling release of astaxanthin in β-sitosterol oleogel-based emulsions via different self-assembled mechanisms and composition of the oleogelators.  FOOD RESEARCH INTERNATIONAL,  186  (114350). 
31. Na Li, Yefan Wang, Zhifeng Tan, Yunpeng Xu, Xiaoyang Liu, Yuxin Liu, Dayong Zhou, Deyang Li.  (2024)  Effect of ultra-high pressure heat-assisted technology combined with L-cysteine on the color of ready-to-eat shrimp during storage.  FOOD CHEMISTRY,  460  (140634). 
32. Xiaorong Huang, Ru Tan, Zhi Geng, Tao Zhang, Guangpeng Feng, Gang Yang, Feng Zhao, Ping Zhuang.  (2024)  Effects of Antarctic Krill Meal in Diet on Reproductive Performance and Embryo Quality of Eriocheir sinensis.  AQUACULTURE NUTRITION,  2024  (9936529). 
33. Xue Qin, Menghao Yang, Xiaolin Wang, Haoqi Xiao, Chaoyue Cao, Jiawen Chai, Weijun Pang.  (2024)  Effects of Astaxanthin on oxidative stress of sows and piglet growth performances.  Livestock Science,  285  (105500). 
34. Yuanzhao Wu, Ye'anlun Zhu, An Cheng, Weixuan Yao, Binjie Wang, Ruonan Zheng, Jiye Wang.  (2025)  Effects of tefluthrin exposure on early life stages in zebrafish: Insights into cardiac and skeletal development, oxidative stress and apoptosis.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  292  (117931). 
35. Jiayan Du, Youtong Bao, Jingyuan Zhu, Xueqing Pang, Depeng Ren, Xinjian Yin, Pingping Zhou.  (2025)  Engineering of β-carotene hydroxylase for enhanced astaxanthin production in Saccharomyces cerevisiae.  BIOCHEMICAL ENGINEERING JOURNAL,  219  (109722). 
36. Chao Wang, Wang Ma, Luwei Xu, Zhiyun Wei, Ke Tang, Jingwen Zhou, Jian Chen.  (2024)  Integrative metabolic engineering and cellular organelle engineering for improving biosynthesis of flavonoid compounds in saccharomyces cerevisiae.  Food Bioscience,    (103996). 
37. Na Li, Xin Fan, Yefan Wang, Kexin Zhang, Rong Liu, Yunpeng Xu, Zhifeng Tan, Wensi Xu, Dayong Zhou, Deyang Li.  (2024)  Investigation of isomerization and oxidation of astaxanthin in ready-to-eat Litopenaeus vannamei during accelerated storage.  FOOD RESEARCH INTERNATIONAL,  195  (114983). 
38. Liu Kangjing, Tian Xueying, Fei Siyuan, Song Yukun, Abd El-Aty A. M., Tan Mingqian.  (2025)  Macrophage and mitochondrion dual-targeting astaxanthin nanoparticles prepared by Maillard reaction for colonic inflammation alleviation.  Marine Life Science & Technology,    (1-14). 
39. Kaixuan Ke, Ling Guo, Zhipeng Qi, Dou Dou, Han Ma, Xianying Fang, Linguo Zhao.  (2024)  Molecular cloning, expression, and biochemical characterization of carotenoid cleavage dioxygenase 1 (LbCCD1) from Lycium barbarum.  Molecular Catalysis,  569  (114561). 
40. Lijuan Zhang, Shan Sun, Wentao Su, Mingqian Tan.  (2025)  Preventive effect of sea bass protein-based high internal phase Pickering emulsion loaded with astaxanthin on DEHP-induced liver lipid metabolism disorder.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  292  (139190). 
41. Xiaoting Yu, Yannan Chen, Mingqian Tan.  (2024)  ROS-responsive carboxymethyl chitosan nanoparticles loaded with astaxanthin for alleviating oxidative damage in intestinal cells.  COLLOIDS AND SURFACES B-BIOINTERFACES,    (113960). 
42. Yafang Li, Jia Wei, Xiaofang Liang, Jiangping Wang, Sisi Yan, Lemei Zhu, Zhen Ding, Chunhua Zhan, Xiaoya Ren, Fei Yang.  (2025)  Sphingopyxis sp. YF1 and metabolite astaxanthin alleviate MC-LR-induced kidney injury.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  197  (106982). 
43. Jia Jianping, Chen Zhitao, Li Qingqing, Li Feifei, Liu Siru, Bao Guoliang.  (2024)  The enhancement of astaxanthin production in Phaffia rhodozyma through a synergistic melatonin treatment and zinc finger transcription factor gene overexpression.  Frontiers in Microbiology,  15   

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