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ASC-J9 - 10mM in DMSO, high purity , CAS No.52328-98-0

    Grade & Purity:
  • 10mM in DMSO
In stock
Item Number
A424487
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Availability
Price Qty
A424487-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$241.90
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Compound libraries (12325)

Basic Description

Synonyms ASC-J9 | 52328-98-0 | Dimethylcurcumin | 917813-54-8 | (1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one | 1,7-Bis-(3,4-dimethoxy-phenyl)-5-hydroxy-hepta-1,4,6-trien-3-one | ASCJ-9 | 1,7-Bis-(3,4-dimethoxyphenyl)-5-hydroxy-hepta-1,4,6-trien-3-one
Specifications & Purity 10mM in DMSO
Biochemical and Physiological Mechanisms

ASC-J9, is antitumor agent. ASC-J9 suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors. Research results suggested that targeting both fAR- and AR3-mediated PCa growt

Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

ASC-J9(GO-Y025; Dimethylcurcumin), is antitumor agent; ASC-J9 suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Diarylheptanoids
Subclass Linear diarylheptanoids
Intermediate Tree Nodes Not available
Direct Parent Curcuminoids
Alternative Parents Cinnamic acids and derivatives  Dimethoxybenzenes  Styrenes  Phenoxy compounds  Anisoles  Alkyl aryl ethers  Vinylogous acids  Enones  Acryloyl compounds  Ketones  Enols  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Curcumin - Cinnamic acid or derivatives - Dimethoxybenzene - O-dimethoxybenzene - Methoxybenzene - Styrene - Phenol ether - Anisole - Phenoxy compound - Alkyl aryl ether - Benzenoid - Monocyclic benzene moiety - Acryloyl-group - Vinylogous acid - Alpha,beta-unsaturated ketone - Enone - Ketone - Ether - Enol - Carbonyl group - Organic oxide - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as curcuminoids. These are aromatic compounds containing a curcumin moiety, which is composed of two aryl buten-2-one (feruloyl) chromophores joined by a methylene group.
External Descriptors Not available

Names and Identifiers

IUPAC Name (1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one
INCHI InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15-
InChIKey ZMGUKFHHNQMKJI-CIOHCNBKSA-N
Smiles COC1=C(C=C(C=C1)C=CC(=CC(=O)C=CC2=CC(=C(C=C2)OC)OC)O)OC
Isomeric SMILES COC1=C(C=C(C=C1)/C=C/C(=C/C(=O)/C=C/C2=CC(=C(C=C2)OC)OC)/O)OC
Molecular Weight 396.43
Reaxy-Rn 19577469
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19577469&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Melt Point(°C) 129-130oC
Molecular Weight 396.400 g/mol
XLogP3 4.600
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 9
Exact Mass 396.157 Da
Monoisotopic Mass 396.157 Da
Topological Polar Surface Area 74.200 Ų
Heavy Atom Count 29
Formal Charge 0
Complexity 596.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 3
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 3
Covalently-Bonded Unit Count 1

Solution Calculators

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