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PI3K/Akt/mTOR
Akt
AS 1949490 - 98%, high purity , CAS No.1203680-76-5, Inhibitor of INPPL1

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AS 1949490 - 98%, high purity , CAS No.1203680-76-5, Inhibitor of INPPL1

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 1203680-76-5
Molecular Weight: 371.88
PubChem CID: 44473434

In stock

Item Number

A287712

Grouped product items
SKU	Size	Availability	Price
A287712-5mg	5mg	3	$98.90
A287712-10mg	10mg	3	$157.90
A287712-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$315.90
A287712-50mg	50mg	2	$505.90
A287712-100mg	100mg	2	$910.90
A287712-250mg	250mg	2	$2,049.90

SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

View related series

Akt (180) Glucose Metabolism (1943) INPPL1 Inhibitor (1) Metabolic Enzyme/Protease (4860) Phosphatase (222) PI3K/Akt/mTOR (765)

Basic Description

Synonyms	AS-16435 \| 3-[(4-Chlorophenyl)methoxy]-N-[(1S) -1-phenylethyl]thiophene-2-carboxamide \| AS 1949490 \| SCHEMBL21857864 \| Q27074523 \| GTPL8878 \| 1203680-76-5 \| A898999 \| AKOS024457770 \| HY-18686 \| J-004322 \| SMR004701459 \| as1949490 \| AS-1949490 \| HMS3678B09
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Selective SHIP2 (inositol 5'-phosphatase 2 containing SH2 domain) inhibitor (IC50 values of mouse and human are 0.34μM and 0.62μM, respectively); compared with SHIP1, the affinity for SHIP2 is about 30 times . Increase insulin-induced phosphorylation of
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of INPPL1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Thiophenes
    - Subclass Thiophene carboxylic acids and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Thiophenes
Subclass	Thiophene carboxylic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Thiophene carboxamides
Alternative Parents	2-heteroaryl carboxamides Chlorobenzenes Alkyl aryl ethers Aryl chlorides Heteroaromatic compounds Secondary carboxylic acid amides Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-heteroaryl carboxamide - Thiophene carboxamide - Alkyl aryl ether - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Ether - Carboxylic acid derivative - Organohalogen compound - Organooxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organochloride - Organonitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as thiophene carboxamides. These are compounds containing a thiophene ring which bears a carboxamide.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

INPPL1 Tchem Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (2 Activities)

Discover Target: INPPL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Inppl1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (2 Activities)

Discover Target: Inppl1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-[(4-chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
INCHI	InChI=1S/C20H18ClNO2S/c1-14(16-5-3-2-4-6-16)22-20(23)19-18(11-12-25-19)24-13-15-7-9-17(21)10-8-15/h2-12,14H,13H2,1H3,(H,22,23)/t14-/m0/s1
InChIKey	RFZPGNRLOKVZJY-AWEZNQCLSA-N
Smiles	CC(C1=CC=CC=C1)NC(=O)C2=C(C=CS2)OCC3=CC=C(C=C3)Cl
Isomeric SMILES	C[C@@H](C1=CC=CC=C1)NC(=O)C2=C(C=CS2)OCC3=CC=C(C=C3)Cl
PubChem CID	44473434
Molecular Weight	371.88

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
L2101148	Certificate of Analysis	Sep 06, 2024	A287712
L2101149	Certificate of Analysis	Sep 06, 2024	A287712
L2101150	Certificate of Analysis	Sep 06, 2024	A287712
L2101151	Certificate of Analysis	Sep 06, 2024	A287712
L2101152	Certificate of Analysis	Sep 06, 2024	A287712
L2101153	Certificate of Analysis	Sep 06, 2024	A287712

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 37.19, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 37.19, Max Conc. mM: 100
Melt Point(°C)	89 - 91°C
Molecular Weight	371.900 g/mol
XLogP3	5.200
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	371.075 Da
Monoisotopic Mass	371.075 Da
Topological Polar Surface Area	66.600 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	422.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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