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Metabolic Enzyme/Protease
Aminoacyl-tRNA Synthetase
Arg-AMS - ≥98.0%, high purity , CAS No.301351-95-1

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Arg-AMS - ≥98.0%, high purity , CAS No.301351-95-1

COA

Grade & Purity:

≥98%

Cas Number: 301351-95-1
Molecular Weight: 502.51
PubChem CID: 9983529

In stock

Item Number

A649116

Grouped product items
SKU	Size	Availability	Price
A649116-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
A649116-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
A649116-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,750.90

View related series

Aminoacyl-tRNA Synthetase (14) Metabolic Enzyme/Protease (4860) Nucleic Acid Metabolism (395)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase , which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase , which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes. In Vitro Arg-AMS inhibits the Orn-activating domain of GrsB with an IC 50 value of 4.6 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Nucleosides, nucleotides, and analogues
  - Class Purine nucleosides

Kingdom	Organic compounds
Superclass	Nucleosides, nucleotides, and analogues
Class	Purine nucleosides
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Purine nucleosides
Alternative Parents	Glycosylamines Pentoses Alpha amino acids and derivatives 6-aminopurines Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Oxolanes Heteroaromatic compounds Organic sulfuric acids and derivatives Secondary alcohols Guanidines 1,2-diols Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Oxacyclic compounds Carboximidamides Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Purine nucleoside - N-glycosyl compound - Glycosyl compound - Pentose monosaccharide - 6-aminopurine - Alpha-amino acid or derivatives - Imidazopyrimidine - Purine - Aminopyrimidine - Pyrimidine - Monosaccharide - N-substituted imidazole - Imidolactam - Azole - Imidazole - Organic sulfuric acid or derivatives - Heteroaromatic compound - Oxolane - Guanidine - Secondary alcohol - Amino acid or derivatives - 1,2-diol - Oxacycle - Azacycle - Carboxylic acid derivative - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Organic oxide - Alcohol - Carbonyl group - Organic oxygen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Primary amine - Primary aliphatic amine - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

RARS Tchem Arginine--tRNA ligase, cytoplasmic (1 Activities)

Discover Target: RARS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RARS1 Tchem Arginyl-tRNA synthetase (4 Activities)

Discover Target: RARS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]sulfamate
INCHI	InChI=1S/C16H26N10O7S/c17-7(2-1-3-21-16(19)20)14(29)25-34(30,31)32-4-8-10(27)11(28)15(33-8)26-6-24-9-12(18)22-5-23-13(9)26/h5-8,10-11,15,27-28H,1-4,17H2,(H,25,29)(H2,18,22,23)(H4,19,20,21)/t7-,8+,10+,11+,15+/m0/s1
InChIKey	BPKLMCNLHSJSEL-JVEUSOJLSA-N
Smiles	C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COS(=O)(=O)NC(=O)C(CCCN=C(N)N)N)O)O)N
Isomeric SMILES	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COS(=O)(=O)NC(=O)[C@H](CCCN=C(N)N)N)O)O)N
PubChem CID	9983529
Molecular Weight	502.51

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	H2O : 100 mg/mL (199.00 mM; Need ultrasonic) DMSO : ≥ 100 mg/mL (199.00 mM)
Molecular Weight	502.500 g/mol
XLogP3	-4.500
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	10
Exact Mass	502.171 Da
Monoisotopic Mass	502.171 Da
Topological Polar Surface Area	291.000 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	838.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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