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Aphidicolin, Ready Made Solution - from Nigrospora sphaerica, high purity , CAS No.38966-21-1
Basic Description
Synonyms
BRN 4689958 | KBioGR_000158 | SMR000058538 | (+/-)-Aphidicolin | ACon1_000511 | DTXSID5036711 | 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol | 6B3F8QW8TU | Bio2_000638 | C20H34O4 | HMS1791H20 | ne-
Specifications & Purity
from Nigrospora sphaerica
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Description
Aphidicolin is a tetracyclic diterpene with antiviral and antimitotic properties used for cell cycle synchronization in various cell lines.Aphidicolin, fromNigrospora sphaerica, was used for cell cycle synchronization of tobacco BY-2 cells. It is used to block the entry of cells into S-phase.
Preparation instructions
Form
Aphidicolin Ready Made Solution supplied as a 1 mg/ml solution in DMSO.
Principle
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Lipids and lipid-like molecules
Class
Prenol lipids
Subclass
Diterpenoids
Intermediate Tree Nodes
Not available
Direct Parent
Aphidicolane and stemodane diterpenoids
Alternative Parents
Tertiary alcohols Secondary alcohols Cyclic alcohols and derivatives Primary alcohols Hydrocarbon derivatives
Molecular Framework
Aliphatic homopolycyclic compounds
Substituents
Aphidicolane or stemodane diterpenoid - Tertiary alcohol - Cyclic alcohol - Secondary alcohol - Organic oxygen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aliphatic homopolycyclic compound
Description
This compound belongs to the class of organic compounds known as aphidicolane and stemodane diterpenoids. These are diterpenoids with a structure based on the aphidicolane or the stemodane skeleton.
External Descriptors
tetracyclic diterpenoid
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
(1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
INCHI
InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChIKey
NOFOAYPPHIUXJR-APNQCZIXSA-N
Smiles
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
Isomeric SMILES
C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
WGK Germany
3
RTECS
PB9185000
Molecular Weight
338.48
Beilstein
4689958
Reaxy-Rn
29827745
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29827745&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Solubility
H2O: miscible (completely)
Molecular Weight
338.500 g/mol
XLogP3
2.500
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
2
Exact Mass
338.246 Da
Monoisotopic Mass
338.246 Da
Topological Polar Surface Area
80.900 Ų
Heavy Atom Count
24
Formal Charge
0
Complexity
524.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
8
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Wensen Zhang, Na Cui, Fazhi Su, Yanping Sun, Biao Li, Yupeng Ren, Ping Wang, Haodong Bai, Wei Guan, Bingyou Yang, Qiuhong Wang, Haixue Kuang.
(2023)
Serum, spleen metabolomics and gut microbiota reveals effect of catalpol on blood deficiency syndrome caused by cyclophosphamide and acetylphenylhydrazine. Frontiers in Immunology,
14
(1280049).
2.
Wang Juan, Wang Furong, Yuan Lixia, Ruan Hongsheng, Zhu Zhibiao, Fan Xiaoling, Zhu Lingyan, Peng Xin.
(2022)
Blood-Enriching Effects and Immune-Regulation Mechanism of Steam-Processed Polygonatum Sibiricum Polysaccharide in Blood Deficiency Syndrome Mice. Frontiers in Immunology,
13
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2 Citations