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Antalarmin hydrochloride - 99%, high purity , CAS No.220953-69-5

COA

Grade & Purity:

≥99%

Cas Number: 220953-69-5
Molecular Weight: 415.01
PubChem CID: 16078945
PubChem SID: 504768031

In stock

Item Number

A286834

Grouped product items
SKU	Size	Availability	Price
A286834-5mg	5mg	3	$117.90
A286834-10mg	10mg	3	$187.90
A286834-25mg	25mg	3	$375.90
A286834-50mg	50mg	2	$602.90

CRF1antagonist

View related series

Class B GPCR (170) CRFR (23) GPCR/G Protein (3172)

Basic Description

Synonyms	DTXSID00582018 \| E98747 \| Antalarmin hydrochloride, >=98% (HPLC), solid \| HY-103377 \| Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine hydrochloride \| N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Non-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki= 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.Antalarmin serves as a non steroidal inhibitor of
Storage Temp	Store at -20°C,Argon charged,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Application： Antalarmin hydrochloride has been used: to study its effect on stress-induced tryptophan hydroxylase 2 activity to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrroles
    - Subclass Substituted pyrroles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrroles
Subclass	Substituted pyrroles
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyrroles
Alternative Parents	Pyrrolo[2,3-d]pyrimidines Dialkylarylamines Aminopyrimidines and derivatives Imidolactams Benzene and substituted derivatives Heteroaromatic compounds Azacyclic compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	1-phenylpyrrole - Pyrrolo[2,3-d]pyrimidine - Pyrrolopyrimidine - Dialkylarylamine - Aminopyrimidine - Monocyclic benzene moiety - Pyrimidine - Imidolactam - Benzenoid - Heteroaromatic compound - Azacycle - Amine - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpyrroles. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrole ring through a CC or CN bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504768031
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504768031
IUPAC Name	N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine;hydrochloride
INCHI	InChI=1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChIKey	CGDGXEDXEXACKQ-UHFFFAOYSA-N
Smiles	CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C.Cl
Isomeric SMILES	CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C.Cl
Molecular Weight	415.01
Reaxy-Rn	8299718
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8299718&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
A2306442	Certificate of Analysis	Nov 19, 2022	A286834
A2306440	Certificate of Analysis	Nov 19, 2022	A286834
C2504164	Certificate of Analysis	Nov 19, 2022	A286834
A2306423	Certificate of Analysis	Nov 19, 2022	A286834
A2306426	Certificate of Analysis	Nov 19, 2022	A286834

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 41.5, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 41.5, Max Conc. mM: 100
Sensitivity	Moisture sensitive
Molecular Weight	415.000 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	414.255 Da
Monoisotopic Mass	414.255 Da
Topological Polar Surface Area	34.000 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	485.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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