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Angiotensinogen, Human Plasma

COA

Grade & Purity:

≥95%(SDS-PAGE)
Extinction Coefficient: 0.92

In stock

Item Number

np001156

Grouped product items
SKU	Size	Availability	Price	Qty
np001156-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$175.90
np001156-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$575.90

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Human Proteins (109)

Basic Description

Product Name	Angiotensinogen, Human Plasma
Product Description	Buy Purified Native Angiotensinogen from Human Plasma direct from the manufacturer. Bulk Qty Available. Angiotensinogen (AGT) is a glycoprotein found in plasma at a concentration of 2.8-7.1 mg per 100mL in healthy individuals. AGT is produced primarily by the liver but also is synthesized in the brain, large arteries, kidneys and adipose tissue. In plasma it exists as a monomeric form (55-65 kDa) as well as a high molecular mass form (200-550 kDa). In non-pregnant individuals with normal blood pressure, the high molecular mass form accounts for 3% of total circulating AGT. In the first half of pregnancy the total AGT increases by 4-fold and the high molecular mass form increases by 20-fold. Up to 80% of the total AGT in amniotic fluid is the high molecular mass form. Angiotensinogen is an essential component of the renin-angiotensin system, a potent regulator of blood pressure, body fluid and electrolyte homeostasis. It functions as the substrate for human renin and is the precursor molecule for Angiotensins 1,2,3,4, 1-9, 1-7, 1-5 and 1-4. AGT is also a member of the SERPIN family but it is not known to possess protease-inhibitory activity. Levels in plasma are increased by plasma corticosteroid, estrogen, thyroid hormone and angiotensin-2 levels. Synonym: Hypertensinogen, Renin substrate Prepared from plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Specifications & Purity	≥95%(SDS-PAGE), Extinction Coefficient: 0.92
Predicted molecular weight	55,000-65,000Da

Storage and Shipping

Shape	Lyophilized from 30 mM sodium phosphate, pH 6.8
Concentration	Extinction Coefficient: 0.92
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

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