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Angiotensin Ⅱ, human - 90%, high purity , CAS No.4474-91-3

40 Citations COA COA
In stock
Item Number
A107852
Grouped product items
SKU Size
Availability
 Price Qty
A107852-5mg
5mg
6
$77.90
A107852-10mg
10mg
4
$140.90
A107852-25mg
25mg
≥10
$290.90
A107852-100mg
100mg
8
$686.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Vasoconstrictor peptide

View related series
Amino acids and their derivatives (62) Angiotensin Receptor (92) Apoptosis (4276) Class A GPCR (4138) GPCR/G Protein (3172) Peptides and proteins (1)

Basic Description

Synonyms CHEBI:131170 | CHEBI:48432 | HB3488 | ty-10721 | Angiotensin II, ile(5)- | Q27293293 | 5-L-Isoleucineangiotensin II | Angiotensin II (acetate);Ang II (acetate);DRVYIHPF (acetate) | C50H71N13O12 | Angiotensinum II | Angiotensin 2 | Angiotensin II (human ty
Specifications & Purity Moligand™, ≥90%
Biochemical and Physiological Mechanisms Angiotensin II is a crucial component of the Renin-Angiotensin System (RAS). It plays a vital role in vasoconstriction, regulating blood pressure, and controlling fluid balance by influencing the retention of sodium and water in the renal tubules. Further
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Product Description

Sequence: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
General description
Research area: Cell signaling
Cell permeable: no
Primary Target adenylate cyclase activity
Product does not compete with ATP.
Reversible: no

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Peptides
Direct Parent Oligopeptides
Alternative Parents Tyrosine and derivatives  Phenylalanine and derivatives  Histidine and derivatives  Aspartic acid and derivatives  Isoleucine and derivatives  Valine and derivatives  Proline and derivatives  N-acyl-L-alpha-amino acids  Alpha amino acid amides  Phenylpropanoic acids  Amphetamines and derivatives  Imidazolyl carboxylic acids and derivatives  Pyrrolidinecarboxamides  N-acylpyrrolidines  1-hydroxy-2-unsubstituted benzenoids  Dicarboxylic acids and derivatives  N-acyl amines  Tertiary carboxylic acid amides  Heteroaromatic compounds  Amino acids  Secondary carboxylic acid amides  Guanidines  Azacyclic compounds  Propargyl-type 1,3-dipolar organic compounds  Carboxylic acids  Carboximidamides  Carbonyl compounds  Hydrocarbon derivatives  Monoalkylamines  Organic oxides  Organopnictogen compounds  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Alpha-oligopeptide - Tyrosine or derivatives - Phenylalanine or derivatives - Histidine or derivatives - Aspartic acid or derivatives - Isoleucine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-acyl-l-alpha-amino acid - Valine or derivatives - Proline or derivatives - Alpha-amino acid amide - 3-phenylpropanoic-acid - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Amphetamine or derivatives - N-acylpyrrolidine - Pyrrolidine-2-carboxamide - Imidazolyl carboxylic acid derivative - Pyrrolidine carboxylic acid or derivatives - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Fatty acyl - Fatty amide - Benzenoid - N-acyl-amine - Pyrrolidine - Tertiary carboxylic acid amide - Imidazole - Heteroaromatic compound - Azole - Amino acid or derivatives - Amino acid - Carboxamide group - Guanidine - Secondary carboxylic acid amide - Carboximidamide - Carboxylic acid - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organooxygen compound - Organopnictogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxygen compound - Primary amine - Organic nitrogen compound - Amine - Organonitrogen compound - Organic oxide - Primary aliphatic amine - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors Angiotensin [KO:K09821]

Associated Targets(Human)

AGTR1 Tclin Type-1 angiotensin II receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
AGTR2 Tchem Type-2 angiotensin II receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNK3 Tclin Potassium channel subfamily K member 3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H295R (47 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Agtr1b Type-1B angiotensin II receptor (525 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGTR1 Angiotensin II type 1a (AT-1a) receptor (440 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Agtr1 Type-1A angiotensin II receptor (520 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Agtr1b Angiotensin II receptor (1735 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Agtr1b Angiotensin II receptor (AT-1) type-1 (1480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504757667
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504757667
IUPAC Name (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
INCHI InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
Smiles CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
Isomeric SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
WGK Germany 3
RTECS BW2165000
Molecular Weight 1046.18
Reaxy-Rn 25124120
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25124120&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

21 results found

Lot Number Certificate Type Date Item
C2528310 Certificate of Analysis Mar 06, 2025 A107852
C2528311 Certificate of Analysis Mar 06, 2025 A107852
C2528312 Certificate of Analysis Mar 06, 2025 A107852
C2528313 Certificate of Analysis Mar 06, 2025 A107852
K2407172 Certificate of Analysis Oct 12, 2024 A107852
K2407173 Certificate of Analysis Oct 12, 2024 A107852
H2318190 Certificate of Analysis Jul 15, 2023 A107852
H2318188 Certificate of Analysis Jul 15, 2023 A107852
H2318189 Certificate of Analysis Jul 15, 2023 A107852
H2318187 Certificate of Analysis Jul 15, 2023 A107852
A2310330 Certificate of Analysis Dec 01, 2022 A107852
A2310302 Certificate of Analysis Dec 01, 2022 A107852
A2310332 Certificate of Analysis Dec 01, 2022 A107852
A2310316 Certificate of Analysis Dec 01, 2022 A107852
A2310322 Certificate of Analysis Dec 01, 2022 A107852
A2310312 Certificate of Analysis Dec 01, 2022 A107852
A2310321 Certificate of Analysis Dec 01, 2022 A107852
A2310303 Certificate of Analysis Dec 01, 2022 A107852
G2226045 Certificate of Analysis Jun 05, 2022 A107852
G2226046 Certificate of Analysis Jun 05, 2022 A107852
I2129182 Certificate of Analysis Sep 18, 2021 A107852

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Chemical and Physical Properties

Solubility insoluble in DMSO; insoluble in EtOH
Sensitivity Heat Sensitive
Molecular Weight 1046.200 g/mol
XLogP3 -1.700
Hydrogen Bond Donor Count 13
Hydrogen Bond Acceptor Count 15
Rotatable Bond Count 29
Exact Mass 1045.53 Da
Monoisotopic Mass 1045.53 Da
Topological Polar Surface Area 409.000 Ų
Heavy Atom Count 75
Formal Charge 0
Complexity 1980.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 9
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Wang Meng-yang, Yu Tian-xiang, Wang Qin-yan, Han Xue, Hu Xiang, Ye Shi-ju, Long Xiao-hong, Wang Yi, Zhu Hong, Luo Wu, Liang Guang.  (2023)  OTUD1 promotes hypertensive kidney fibrosis and injury by deubiquitinating CDK9 in renal epithelial cells.  ACTA PHARMACOLOGICA SINICA,    (1-12). 
2. Jiajia Zhang, Yu Tu, Jiajia Wei, Ruyi Zheng, Ji Shao, Qinhua Chen, Guang Liang, Huazhong Ying, Xue Han, Qiaojuan Shi.  (2023)  Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,    (166911). 
3. Yushu Liu, Dong Wang, Yimin Jin, Guifang Sun, Qi Lou, Hong Wang, Weimin Li.  (2023)  Costunolide ameliorates angiotensin II-induced atrial inflammation and fibrosis by regulating mitochondrial function and oxidative stress in mice: A possible therapeutic approach for atrial fibrillation.  MICROVASCULAR RESEARCH,    (104600). 
4. Wang Shuai, Bai Jie, Che Yilin, Qu Weikun, Li Jing.  (2023)  Fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1.  Frontiers in Pharmacology,  14   
5. Fangze Huang, Ximao Liu, Junjie Liu, Yu Xie, Li Zhao, Deshen Liu, Zifeng Zeng, Xiu Liu, Shaoyi Zheng, Zezhou Xiao.  (2023)  Phosphatidylethanolamine aggravates Angiotensin II-induced atrial fibrosis by triggering ferroptosis in mice.  Frontiers in Pharmacology,  14  (1148410). 
6. Mengyang Wang, Xue Han, Tianxiang Yu, Minxiu Wang, Wu Luo, Chunpeng Zou, Xiuyun Li, Gao Li, Gaojun Wu, Yi Wang, Guang Liang.  (2023)  OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes.  Theranostics,  13  (7): ( 2263–2280). 
7. Tian-Lun Wen, Jia-Hui Bai, Ming-Mai Bao, Yong Qin, Yue Su, Yin-Long Guo.  (2023)  Ultrasonic sample introduction combined with flame assisted thermal ionization: Pretreatment-free direct mass spectrometry analysis for fraction collecting tubes of preparative liquid chromatography.  TALANTA,  259  (124508). 
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9. Siyuan Shen, Gaojun Wu, Wu Luo, Weixin Li, Xiaobo Li, Chengyi Dai, Weijian Huang, Guang Liang.  (2023)  Leonurine attenuates angiotensin II-induced cardiac injury and dysfunction via inhibiting MAPK and NF-κB pathway.  PHYTOMEDICINE,  108  (154519). 
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12. Yawen Deng, Zhitong Li, Xiangbo An, Rui Fan, Yao Wang, Jiatian Li, Xiaolei Yang, Jiawei Liao, Yunlong Xia.  (2022)  Hyperhomocysteinemia Promotes Cardiac Hypertrophy in Hypertension.  Oxidative Medicine and Cellular Longevity,  2022  (1486157). 
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14. Mengyang Wang, Wu Luo, Tianxiang Yu, Shiqi Liang, Jinfeng Sun, Yi Zhang, Xue Han, Xiaohong Long, Guang Liang, Gao Li.  (2022)  Corynoline protects ang II-induced hypertensive heart failure by increasing PPARα and Inhibiting NF-κB pathway.  BIOMEDICINE & PHARMACOTHERAPY,  150  (113075). 
15. Guangquan Hu, Xiaojie Ding, Feng Gao, Jiehua Li.  (2022)  Calcium and integrin binding protein 1 (CIB1) induces myocardial fibrosis in myocardial infarction via regulating the PI3K/Akt pathway.  EXPERIMENTAL ANIMALS,     
16. Jinfu Qian, Wu Luo, Chengyi Dai, Jun Wang, Xinfu Guan, Chunpeng Zou, Nipon Chattipakorn, Gaojun Wu, Weijian Huang, Guang Liang.  (2021)  Myeloid differentiation protein 2 mediates angiotensin II-induced inflammation and mesenchymal transition in vascular endothelium.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,  1867  (166043). 
17. Ke Lin, Wu Luo, Jueqian Yan, Siyuan Shen, Qirui Shen, Jun Wang, Xinfu Guan, Gaojun Wu, Weijian Huang, Guang Liang.  (2021)  TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-κB signaling.  Aging-US,  13  (2): ( 2553–2574). 
18. Zhengyong Wang, Yuqi Cao, Yingjie Lu, Fang Zhang, Yue Su, Yinlong Guo.  (2020)  Ultrasonic extraction and nebulization in real-time coupled with carbon fiber ionization mass spectrometry for rapid screening of the synthetic drugs adulterated into herbal products.  ANALYTICA CHIMICA ACTA,  1136  (62). 
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20. Rui Guo, Ningning Liu, Hao Liu, Junhua Zhang, Han Zhang, Yingchao Wang, Mirko Baruscotti, Lu Zhao, Yi Wang.  (2020)  High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3.  PHYTOMEDICINE,  68  (153171). 
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22. Xin Xie, Hai-Lian Bi, Song Lai, Yun-Long Zhang, Nan Li, Hua-Jun Cao, Ling Han, Hong-Xia Wang, Hui-Hua Li.  (2019)  The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.  Science Advances,  5  (5):  
23. Zheng Xu, Chunpeng Zou, Weihui Yu, Sujing Xu, Lan Huang, Zia Khan, Jingying Wang, Guang Liang, Yi Wang.  (2019)  Inhibition of STAT3 activation mediated by toll-like receptor 4 attenuates angiotensin II-induced renal fibrosis and dysfunction.  BRITISH JOURNAL OF PHARMACOLOGY,  176  (14): (2627-2641). 
24. Dandan Chen, Zhe Li, Peiqing Bao, Miao Chen, Miao Zhang, Fangrong Yan, Yitao Xu, Caoyu Ji, Xinyue Hu, Daniel Sanchis, Yubin Zhang, Junmei Ye.  (2019)  Nrf2 deficiency aggravates Angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6/STAT3-dependent inflammation.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,  1865  (1253). 
25. Qing Shu, Song Lai, Xiao-Mei Wang, Yun-Long Zhang, Xiao-Lei Yang, Hai-Lian Bi, Hui-Hua Li.  (2018)  Administration of ubiquitin-activating enzyme UBA1 inhibitor PYR-41 attenuates angiotensin II-induced cardiac remodeling in mice.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,  505  (317). 
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33. Pingping Tuo, Risheng Zhao, Ning Li, Shuang Yan, Gege Yang, Chunmei Wang, Jinghui Sun, Haiming Sun, Mengyang Wang.  (2024)  Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT/NF-κB pathway.  PHYTOMEDICINE,  128  (155464). 
34. Meili Zhu, Jiangbiao Hu, Yifan Pan, Qian Jiang, Chang Shu.  (2024)  Magnoflorine attenuates Ang II-induced cardiac remodeling via promoting AMPK-regulated autophagy.  Cardiovascular Diagnosis and Therapy,  14  (4): (576). 
35. Lu Wang, Wanyue Sang, Yi Jian, Yafan Han, Feifei Wang, Subinuer Wubulikasimu, Li Yang, Baopeng Tang, Yaodong Li.  (2025)  MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,  199  (1). 
36. Xiao-Xiao Jiang, Ri Zhang, Hui-Shan Wang.  (2024)  Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.  Aging-US,  16  (10): (8630-8644). 
37. Yanyan Sun, Zhenzhen Hu, Jie Han, Gang Li.  (2024)  SP1-mediated transcriptional repression of SFRP5 is correlated with cardiac fibroblast activation and atrial myocyte apoptosis in the development of atrial fibrillation.  EXPERIMENTAL CELL RESEARCH,  443  (114326). 
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