Skip to the beginning of the images gallery

Andolast free base - 10mM in DMSO, high purity , CAS No.132640-22-3(DMSO), Calcium-activated potassium channel subunit alpha-1 activator

COA

Grade & Purity:

10mM in DMSO

Cas Number: 132640-22-3(DMSO)
Molecular Weight: 333.31

In stock

Item Number

A655764

Grouped product items
SKU	Size	Availability	Price	Qty
A655764-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$61.90

View related series

Compound libraries (12325) Metabolic Enzyme/Protease (4860) Phosphodiesterase (PDE) (252)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC 50 value of 50 μM. Andolast can be used for the research of asthma.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	ACTIVATOR
Mechanism of action	Calcium-activated potassium channel subunit alpha-1 activator
Product Description	Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC 50 value of 50 μM. Andolast can be used for the research of asthma. In Vivo Andolast (CR 2039) (i.v. or i.m.) inhibits rat passive cutaneous anaphylaxis (PCA) with an ED 50 of 0.1 mg/kg . CR 2039 (10-100 mg/kg; i.v. or i.m.) inhibits the microvascular permeability changes in a model of allergic conjunctivitis in sensitized guinea-pigs . CR 2039 (0-1000 μM; i.v.) inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC 50 value of 50 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Hartley guinea-pigs (300-500 g) Dosage: 10-100 mg/kg Administration: I.M; I.V. Result: Showed dose-related significant protection against lgE-dependent bronchial anaphylaxis induced by aerosolized antigen in anesthetized guinea-pigs. Delayed dose dependently the onset of bronchoconstriction induced by aerosolized antigen.

Names and Identifiers

Smiles	O=C(C1=CC=C(C2=NN=NN2)C=C1)NC3=CC=C(C4=NN=NN4)C=C3
Molecular Weight	333.31

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration