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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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A105482-250mg
|
250mg |
3
|
$23.90
|
|
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A105482-1g
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1g |
3
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$66.90
|
|
|
A105482-5g
|
5g |
3
|
$199.90
|
|
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A105482-25g
|
25g |
3
|
$9,003.90
|
|
|
A105482-100g
|
100g |
2
|
$32,411.90
|
|
Antimycotic polyene
| Synonyms | Amfotericina B [INN-Spanish] | BRN 0078342 | EINECS 215-742-2 | MFCD00877763 | Amphotericin B liposome | C06573 | AMPH-B | AMPHOTERACIN B | AMPHOTERICIN B [JAN] | Mysteclin-F | Q412223 | s1636 | 1397-89-3, C47H73NO17 | Amphotericin B, Streptomyces nodosus |
|---|---|
| Specifications & Purity | ≥80%, 750 μg/mg |
| Biochemical and Physiological Mechanisms | Antimycotic polyene. Disrupts fungal cell membrane permeability by targeting sterols such as ergosterol. Active in vivo . |
| Storage Temp | Store at 2-8°C |
| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Class | Organooxygen compounds |
| Subclass | Carbohydrates and carbohydrate conjugates |
| Intermediate Tree Nodes | Aminosaccharides |
| Direct Parent | Aminoglycosides |
| Alternative Parents | Macrolides and analogues Hexoses O-glycosyl compounds Beta hydroxy acids and derivatives Oxanes Dicarboxylic acids and derivatives Secondary alcohols 1,2-aminoalcohols Amino acids Lactones Hemiacetals Carboxylic acid esters Polyols Oxacyclic compounds Acetals Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides Organopnictogen compounds |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Aminoglycoside core - Macrolide - Hexose monosaccharide - O-glycosyl compound - Glycosyl compound - Beta-hydroxy acid - Dicarboxylic acid or derivatives - Oxane - Hydroxy acid - Monosaccharide - 1,2-aminoalcohol - Hemiacetal - Secondary alcohol - Lactone - Carboxylic acid ester - Amino acid or derivatives - Amino acid - Carboxylic acid derivative - Polyol - Organoheterocyclic compound - Oxacycle - Acetal - Carboxylic acid - Organic nitrogen compound - Primary aliphatic amine - Organonitrogen compound - Carbonyl group - Primary amine - Hydrocarbon derivative - Organic oxide - Amine - Alcohol - Organopnictogen compound - Aliphatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars. |
| External Descriptors | Polyenes |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid |
|---|---|
| INCHI | InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1 |
| InChIKey | APKFDSVGJQXUKY-INPOYWNPSA-N |
| Smiles | CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O |
| Isomeric SMILES | C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O |
| Molecular Weight | 924.08 |
| Beilstein | 78342 |
| Reaxy-Rn | 31131291 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31131291&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 17, 2025 | A105482 | |
| Certificate of Analysis | Dec 17, 2024 | A105482 | |
| Certificate of Analysis | Mar 11, 2024 | A105482 | |
| Certificate of Analysis | Nov 08, 2023 | A105482 | |
| Certificate of Analysis | Nov 06, 2023 | A105482 | |
| Certificate of Analysis | Mar 26, 2021 | A105482 | |
| Certificate of Analysis | Mar 26, 2021 | A105482 | |
| Certificate of Analysis | Mar 26, 2021 | A105482 | |
| Certificate of Analysis | Mar 26, 2021 | A105482 |
| Solubility | Soluble in aqueous buffers at pH 2.0 or 11.0. Insoluble at pH 6.0-7.0. Also soluble in DMSO or DMF |
|---|---|
| Sensitivity | Light & Moisture sensitive |
| Melt Point(°C) | >170°C |
| Molecular Weight | 924.100 g/mol |
| XLogP3 | 0.000 |
| Hydrogen Bond Donor Count | 12 |
| Hydrogen Bond Acceptor Count | 18 |
| Rotatable Bond Count | 3 |
| Exact Mass | 923.488 Da |
| Monoisotopic Mass | 923.488 Da |
| Topological Polar Surface Area | 320.000 Ų |
| Heavy Atom Count | 65 |
| Formal Charge | 0 |
| Complexity | 1670.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 19 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 7 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 7 |
| Covalently-Bonded Unit Count | 1 |
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| 7. Zhongjia Yu, Xiang-Fang Yu, Goher Kerem, Pei-Gen Ren. (2022) Perturbation on gut microbiota impedes the onset of obesity in high fat diet-induced mice. Frontiers in Endocrinology, 13 (795371). |
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| 9. Xiaowen He, Lantong Zhang, Jinping Chen, Jinlei Sui, Guohui Yi, Jinyan Wu, Yinzheng Ma. (2019) Correlation between Chemical Composition and Antifungal Activity of Clausena lansium Essential Oil against Candida spp.. MOLECULES, 24 (7): (1394). |
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| 15. Yang Yang, Yuanji Zhao, Huan Lei, Xiaohong Tan. (2024) Limosilactobacillus Fermentun ZS09 Can Improve Antibiotic-Induced Motor Dysfunction in Mice by Regulating the Brain–Gut Functions. Journal of Inflammation Research, |
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