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Aminoguanidine Hydrochloride - 10mM in DMSO, high purity , CAS No.1937-19-5

    Grade & Purity:
  • 10mM in DMSO
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Item Number
A422366
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A422366-1ml
1ml
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$69.90

NOS inhibitor

Basic Description

Synonyms Aminoguanidine hydrochloride | 1937-19-5 | 16139-18-7 | Pimagedine hydrochloride | Pimagedine HCl | Hydrazinecarboximidamide, monohydrochloride | Aminoguanidine HCl | Carbazamidine hydrochloride | Hydrazinecarboximidamide hydrochloride | Guanylhydrazine hydrochloride | 1-ami
Specifications & Purity 10mM in DMSO
Biochemical and Physiological Mechanisms Inhibits both constitutive and inducible nitric oxide synthetase. .Irreversible inhibitor of iNOS, displaying 26-fold selectivity over nNOS.
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Product Introduction

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Product Usage

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic nitrogen compounds
Class Organonitrogen compounds
Subclass Guanidines
Intermediate Tree Nodes Not available
Direct Parent Guanidines
Alternative Parents Organopnictogen compounds  Organic chloride salts  Hydrocarbon derivatives  
Molecular Framework Aliphatic acyclic compounds
Substituents Guanidine - Organopnictogen compound - Hydrocarbon derivative - Organic chloride salt - Organic salt - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as guanidines. These are compounds containing a guanidine moiety, with the general structure (R1R2N)(R3R4N)C=N-R5.
External Descriptors Not available

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2-aminoguanidine;hydrochloride
INCHI InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChIKey UBDZFAGVPPMTIT-UHFFFAOYSA-N
Smiles C(=NN)(N)N.Cl
Isomeric SMILES C(=NN)(N)N.Cl
WGK Germany 3
RTECS ME8430000
UN Number 3077
Packing Group III
Molecular Weight 110.55
Reaxy-Rn 7134851
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7134851&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity Air & Moisture & heat & light sensitive
Melt Point(°C) 162-166 °C
Molecular Weight 110.550 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 0
Exact Mass 110.036 Da
Monoisotopic Mass 110.036 Da
Topological Polar Surface Area 90.400 Ų
Heavy Atom Count 6
Formal Charge 0
Complexity 41.600
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

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2. Weiming Chai, Qiuxia Pan, Qiuhan Bai, Yifeng Wu, Wenshuang Wei, Linjun Wang, Du Zhu.  (2023)  Condensed tannins from the leave of Dimocarpus longan Lour. exhibit anti-tyrosinase, anti-melanogenesis, anti-browning, anti-α-glucosidase, and anti-glycation activities.  INDUSTRIAL CROPS AND PRODUCTS,  206  (117605). 
3. Qinhao Guan, Lihua Tang, Liangliang Zhang, Lixin Huang, Man Xu, Yuan Wang, Meng Zhang.  (2023)  Molecular insights into α-glucosidase inhibition and antiglycation properties affected by the galloyl moiety in (−)-epigallocatechin-3-gallate.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (15): (7381-7392). 
4. Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao, Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, Junjie Zhang.  (2023)  Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity.  Molecular Therapy-Oncolytics,  29  (61-76). 
5. Zhou Huiji, Zhou Luxian, Li Bo, Yue Rongcai.  (2023)  Anti-cyclooxygenase, anti-glycation, and anti-skin aging effect of Dendrobium officinale flowers’ aqueous extract and its phytochemical validation in aging.  Frontiers in Immunology,  14   
6. Qinglu Li, Ruihua Tang, Hao Zhou, Xuxu Hu, Sufeng Zhang.  (2023)  A high-performance and flexible electrode film based on bacterial cellulose/polypyrrole/nitrogen-doped graphene for supercapacitors.  CARBOHYDRATE POLYMERS,  311  (120754). 
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10. Yishan Fu, Xiaojing Liu, Qian Ma, Junjie Yi, Shengbao Cai.  (2021)  Phytochemical bioaccessibility and in vitro antidiabetic effects of Chinese sumac (Rhus chinensis Mill.) fruits after a simulated digestion: insights into the mechanisms with molecular docking analysis.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  57  (5): (2656-2669). 
11. Jiangnan Zheng, Yuan Mao, Shun Feng, Ruijun Tian.  (2021)  Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned Medium†.  CHINESE JOURNAL OF CHEMISTRY,  39  (7): (1843-1848). 
12. Shuang Song, Qing Liu, Wei-Ming Chai, Si-Shi Xia, Zi-Yi Yu, Qi-Ming Wei.  (2021)  Inhibitory potential of 4-hexylresorcinol against α-glucosidase and non-enzymatic glycation: Activity and mechanism.  JOURNAL OF BIOSCIENCE AND BIOENGINEERING,  131  (241). 
13. Halah Aalim, Di Wang, Zisheng Luo.  (2021)  Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.  FOOD RESEARCH INTERNATIONAL,  141  (109898). 
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15. Halah Aalim, Tarun Belwal, Lei Jiang, Hao Huang, Xianghe Meng, Zisheng Luo.  (2019)  Extraction optimization, antidiabetic and antiglycation potentials of aqueous glycerol extract from rice (Oryza sativa L.) bran.  LWT-FOOD SCIENCE AND TECHNOLOGY,  103  (147). 
16. Yuanhong Chen, Feng Gao, Yan He, Meijun Liu, Yuan Quan, Peijing Zhang.  (2024)  DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma.  iScience,  27  (109181). 
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19. Chunling Lai, Meiling Huang, Qin Xiong, Yan Liang, Yueming Jiang, Jun Zhang.  (2024)  Green and efficient approach to extract bioactive flavonoids with antioxidant, antibacterial, antiglycation, and enzyme inhibitory activities from navel orange peel.  Sustainable Chemistry and Pharmacy,  38  (101479). 
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22. Yilin Yin, Jiaqi Wang, Tong Xu, Meichen Liu, Xu Shi, Shiwen Xu.  (2024)  New Insights into the Toxic Effects of Different Sizes of Nanosilica Particles in Food on the Mouse Bladder: Involving Epithelial–Mesenchymal Transition.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  72  (46): (25919-25930). 
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